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Ono Pharmaceutical CoTSE:4528 +0.06%89 Piotroski F-Score is 9 as of Aug. 13, 2026, which is 50% above its 10-year median of 6.00. GuruFocus rates TSE:4528 with a GF Score™ of 89/100 and a GF Value™ of 円2,169.19 (Modestly Overvalued). The stock has 2 warning signs investors should review. Among 976 Drug Manufacturers companies, Ono Pharmaceutical Co ranks better than 99.9% on this metric.
Good Sign:
Piotroski F-Score is 9, indicates a very healthy situation.
The zones of discrimination were as such:
Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Ono Pharmaceutical Co has an F-score of 9. It is a good or high score, which usually indicates a very healthy situation.
The historical rank and industry rank for Ono Pharmaceutical Co's Piotroski F-Score or its related term are showing as below:
TSE:4528'
s Piotroski F-Score Range Over the Past 10 Years
Min: 4 Med: 6 Max: 9
Current: 9
During the past 13 years, the highest Piotroski F-Score of Ono Pharmaceutical Co was 9. The lowest was 4. And the median was 6.
Ono Pharmaceutical Co (TSE:4528) Piotroski F-Score Explanation
The developer of the system is Joseph D. Piotroski is relatively unknown accounting professor who shuns publicity and rarely gives interviews.
He graduated from the University of Illinois with a B.S. in accounting in 1989, received an M.B.A. from Indiana University in 1994. Five years later, in 1999, after earning a Ph.D. in accounting from the University of Michigan, he became an associate professor of accounting at the University of Chicago.
He wanted to see if he can develop a system (using a simple nine-point scoring system) that can increase the returns of a strategy of investing in low price to book (referred to in the paper as high book to market) value companies.
What he found was something that exceeded his most optimistic expectations.
Buying only those companies that scored highest (8 or 9) on his nine-point scale, or F-Score as he called it, over the 20 year period from 1976 to 1996 led to an average out-performance over the market of 13.4%.
Even more impressive were the results of a strategy of investing in the highest F-Score companies (8 or 9) and shorting companies with the lowest F-Score (0 or 1).
Over the same period from 1976 to 1996 (20 years) this strategy led to an average yearly return of 23%, substantially outperforming the average S&P 500 index return of 15.83% over the same period.
Ono Pharmaceutical Co Piotroski F-Score Related Terms
Ono Pharmaceutical Co Piotroski F-Score Historical Data
* Premium members only.
The historical data trend for Ono Pharmaceutical Co's Piotroski F-Score can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TSE:4528 vs LLY, JNJ, ABBV: Piotroski F-Score Comparison
For the Drug Manufacturers - General subindustry, Ono Pharmaceutical Co's Piotroski F-Score, along with its competitors' market caps and Piotroski F-Score data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Ono Pharmaceutical Co Piotroski F-Score vs Drug Manufacturers Industry
For the Drug Manufacturers industry and Healthcare sector, Ono Pharmaceutical Co's Piotroski F-Score distribution charts can be found below:
* The bar in red indicates where Ono Pharmaceutical Co's Piotroski F-Score falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
*Note: If the latest quarterly/semi-annual/annual total assets data is 0, then we will use previous quarterly/semi-annual/annual data for all the items in the balance sheet.
Profitability
Question 1. Return on Assets (ROA)
Net income before extraordinary items for the year divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Ono Pharmaceutical Co's current Net Income (TTM) was 76,245.
==> Positive ==> Score 1.
Question 2. Cash Flow Return on Assets (CFROA)
Net cash flow from operating activities (operating cash flow) divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Ono Pharmaceutical Co's current Cash Flow from Operations (TTM) was 134,501.
==> Positive ==> Score 1.
Question 3. Change in Return on Assets
Compare this year's return on assets (1) to last year's return on assets.
Ono Pharmaceutical Co's return on assets of this year was 0.0744879. Ono Pharmaceutical Co's return on assets of last year was 0.0396107.
==> This year is higher. ==> Score 1.
Question 4. Quality of Earnings (Accrual)
Compare Cash flow return on assets (2) to return on assets (1)
Ono Pharmaceutical Co's gearing of this year was 0.06980028. Ono Pharmaceutical Co's gearing of last year was 0.09929072.
==> This year is lower or equal to last year. ==> Score 1.
Question 6. Change in Working Capital (Liquidity)
Compare this year's current ratio (current assets divided by current liabilities) to last year's current ratio.
Score 1 if this year's current ratio is higher, 0 if it's lower
Ono Pharmaceutical Co's current ratio of this year was 3.28330112. Ono Pharmaceutical Co's current ratio of last year was 2.9869531.
==> This year's current ratio is higher. ==> Score 1.
Question 7. Change in Shares in Issue
Compare the number of shares in issue this year, to the number in issue last year.
Score 0 if there is larger number of shares in issue this year, 1 otherwise.
Ono Pharmaceutical Co's number of shares in issue this year was 470.047. Ono Pharmaceutical Co's number of shares in issue last year was 470.277.
==> There is smaller number of shares in issue this year, or the same. ==> Score 1.
Efficiency
Question 8. Change in Gross Margin
Compare this year's gross margin (Gross Profit divided by sales) to last year's.
Score 1 if this year's gross margin is higher, 0 if it's lower.
Ono Pharmaceutical Co's gross margin of this year was 0.73556975. Ono Pharmaceutical Co's gross margin of last year was 0.68737267.
==> This year's gross margin is higher. ==> Score 1.
Question 9. Change in asset turnover
Compare this year's asset turnover (total sales for the year divided by total assets at the beginning of the year) to last year's asset turnover ratio.
Score 1 if this year's asset turnover ratio is higher, 0 if it's lower
Ono Pharmaceutical Co's asset turnover of this year was 0.4927847. Ono Pharmaceutical Co's asset turnover of last year was 0.45836798.
==> This year's asset turnover is higher. ==> Score 1.
Evaluation
Piotroski F-Score
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Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Ono Pharmaceutical Co has an F-score of 9. It is a good or high score, which usually indicates a very healthy situation.
Ono Pharmaceutical Co (TSE:4528) has a Piotroski F-Score of 9 as of Aug. 13, 2026. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Ono Pharmaceutical Co and its competitors. This is 50% above median its historical median of 6.00. Over the past decade, Ono Pharmaceutical Co's Piotroski F-Score has ranged from 4.00 to 9.00. According to the industry distribution chart, Ono Pharmaceutical Co ranks #1 out of 976 companies in the Drug Manufacturers industry, placing it in the top 0.099999999999994%.
Is Ono Pharmaceutical Co's Piotroski F-Score too high?
Ono Pharmaceutical Co's current Piotroski F-Score of 9 is 50% above median its 10-year median of 6.00. Over the past 10 years, this metric has ranged from a low of 4.00 to a high of 9.00. The Drug Manufacturers industry median Piotroski F-Score is 5.00. Ono Pharmaceutical Co's value of 9 is 80% above this industry median. Based on the distribution chart, Ono Pharmaceutical Co ranks #1 out of 976 companies in the Drug Manufacturers industry, which is in the top quartile — a strong position relative to peers. Overall, Ono Pharmaceutical Co has a GF Score™ of 89/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Ono Pharmaceutical Co's Piotroski F-Score compare to LLY and JNJ?
According to the Drug Manufacturers industry distribution chart, Ono Pharmaceutical Co ranks #1 out of 976 companies for Piotroski F-Score. This places Ono Pharmaceutical Co in the top 0% of its industry — outperforming the majority of peers. The industry median Piotroski F-Score is 5.00. Ono Pharmaceutical Co's value of 9 is 80% above this benchmark. Historically, Ono Pharmaceutical Co's own Piotroski F-Score has ranged from 4.00 to 9.00 over the past decade. While the company's 10-year median is 6.00 vs. the industry median of 5.00, Ono Pharmaceutical Co has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Piotroski F-Score for a Drug Manufacturers company?
The median Piotroski F-Score among Drug Manufacturers companies is 5.00, based on 976 companies in the industry. Companies in the top quartile (top 25%) have a Piotroski F-Score significantly above this median, while those in the bottom quartile fall well below. However, Piotroski F-Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Ono Pharmaceutical Co's current Piotroski F-Score of 9 is 80% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Piotroski F-Score mean?
A high Piotroski F-Score can signal that a stock is expensive relative to its fundamentals. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Ono Pharmaceutical Co and its competitors. For the Drug Manufacturers industry, the median Piotroski F-Score is 5.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Ono Pharmaceutical Co's current Piotroski F-Score is 9, which is 50% above median its own 10-year median of 6.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ono Pharmaceutical Co stock overvalued right now?
Based on GuruFocus' analysis, Ono Pharmaceutical Co (TSE:4528) is currently considered Modestly Overvalued. The stock's GF Value™ is 円2,169.19, compared to a current price of 円2,417.50 — trading 11.4% above its estimated fair value. The current Piotroski F-Score is 9, which is 50% above median its 10-year median of 6.00 and 80% above the Drug Manufacturers industry median of 5.00. Ono Pharmaceutical Co's overall GF Score™ is 89/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Piotroski F-Score calculated?
Piotroski F-Score is calculated from a company's financial statements. For Ono Pharmaceutical Co (TSE:4528), the current Piotroski F-Score is 9 as of Aug. 13, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Ono Pharmaceutical Co (TSE:4528) Overvalued in 2026?
Based on GuruFocus' analysis, Ono Pharmaceutical Co stock appears to be overvalued.
The current stock price of 円2,417.50 is trading 11.4% above its estimated GF Value™ of 円2,169.19.
GuruFocus considers Ono Pharmaceutical Co to be Modestly Overvalued.
Key valuation signals for TSE:4528:
Piotroski F-Score: 9 (50% above median its 10-year median of 6.00)
GF Value™: 円2,169.19 vs. price of 円2,417.50 (11.4% above fair value)
Industry Position: 80% above the Drug Manufacturers median (#1 of 976)
No single metric tells the full story. See the TSE:4528 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Ono Pharmaceutical Co Ltd is a drug manufacturer with a focus on drug discovery in areas of unmet medical needs. The vast majority of the company's revenue is derived from its circulatory and respiratory drugs, followed by its metabolic drugs and vitamins. The company also reports revenue derived from royalties. The bulk of the company's sales is generated in Japan, followed by the rest of Asia and Europe.
89GF Score
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