Ono Pharmaceutical Co (TSE:4528) E10: 円162.51 (As of Mar. 2026)


TSE:4528 Ono Pharmaceutical Co Ltd TSE:4528
88 GF Score
Price 円2,377.50
GF Value 円2,255.53
Valuation Fairly Valued
! 2 Warning Signs
View Full Analysis

What is Ono Pharmaceutical Co E10?

Ono Pharmaceutical Co TSE:4528 +1.58% 88 E10 is 円162.51 as of Mar. 2026. GuruFocus rates TSE:4528 with a GF Score™ of 88/100 and a GF Value™ of 円2,255.53 (Fairly Valued). The stock has 2 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Ono Pharmaceutical Co's adjusted earnings per share data for the three months ended in Mar. 2026 was 円1.710. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is 円162.51 for the trailing ten years ended in Mar. 2026.

During the past 12 months, Ono Pharmaceutical Co's average E10 Growth Rate was 7.70% per year. During the past 3 years, the average E10 Growth Rate was 15.00% per year. During the past 5 years, the average E10 Growth Rate was 18.50% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

During the past 13 years, the highest 3-Year average E10 Growth Rate of Ono Pharmaceutical Co was 22.90% per year. The lowest was 13.90% per year. And the median was 17.30% per year.

As of today (2026-06-29), Ono Pharmaceutical Co's current stock price is 円2377.50. Ono Pharmaceutical Co's E10 for the quarter that ended in Mar. 2026 was 円162.51. Ono Pharmaceutical Co's Shiller PE Ratio of today is 14.63.

During the past 13 years, the highest Shiller PE Ratio of Ono Pharmaceutical Co was 67.10. The lowest was 9.95. And the median was 34.64.


Ono Pharmaceutical Co  (TSE:4528) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

Ono Pharmaceutical Co's Shiller P/E Ratio of today is calculated as

Shiller PE Ratio=Share Price/E10
=2377.50/162.51
=14.63

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Shiller P/E Ratio of Ono Pharmaceutical Co was 67.10. The lowest was 9.95. And the median was 34.64.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Ono Pharmaceutical Co E10 Related Terms


Ono Pharmaceutical Co E10 Historical Data

* Premium members only.

The historical data trend for Ono Pharmaceutical Co's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Ono Pharmaceutical Co E10 Chart

Ono Pharmaceutical Co Annual Data
Trend Mar17 Mar18 Mar19 Mar20 Mar21 Mar22 Mar23 Mar24 Mar25 Mar26
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only 85.42 106.76 135.63 150.86 162.51

Ono Pharmaceutical Co Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 150.86 153.41 158.07 164.04 162.51

TSE:4528 vs LLY, JNJ, ABBV: E10 Comparison

For the Drug Manufacturers - General subindustry, Ono Pharmaceutical Co's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Ono Pharmaceutical Co Shiller PE Ratio vs Drug Manufacturers Industry

For the Drug Manufacturers industry and Healthcare sector, Ono Pharmaceutical Co's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Ono Pharmaceutical Co's Shiller PE Ratio falls into.


TSE:4528
88GF Score
Ono Pharmaceutical Co Ltd TSE:4528
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Ono Pharmaceutical Co E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Ono Pharmaceutical Co's adjusted earnings per share data for the three months ended in Mar. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=1.71/112.7000*112.7000
=1.710

Current CPI (Mar. 2026) = 112.7000.

Ono Pharmaceutical Co Quarterly Data

per share eps CPI Adj_EPS
201606 25.810 98.100 29.651
201609 17.810 98.000 20.482
201612 36.510 98.400 41.816
201703 25.130 98.100 28.870
201706 22.310 98.500 25.526
201709 18.280 98.800 20.852
201712 39.340 99.400 44.604
201803 17.250 99.200 19.598
201806 29.630 99.200 33.662
201809 26.470 99.900 29.862
201812 27.790 99.700 31.414
201903 16.350 99.700 18.482
201906 31.840 99.800 35.956
201909 32.730 100.100 36.850
201912 38.080 100.500 42.703
202003 15.920 100.300 17.888
202006 43.060 99.900 48.577
202009 36.760 99.900 41.470
202012 53.360 99.300 60.561
202103 17.900 99.900 20.193
202106 48.220 99.500 54.617
202109 44.500 100.100 50.101
202112 36.820 100.100 41.455
202203 32.570 101.100 36.307
202206 60.360 101.800 66.823
202209 67.300 103.100 73.567
202212 68.220 104.100 73.856
202303 34.910 104.400 37.685
202306 65.150 105.200 69.795
202309 88.180 106.200 93.577
202312 75.760 106.800 79.945
202403 37.510 107.200 39.434
202406 52.750 108.200 54.944
202409 26.910 108.900 27.849
202412 40.760 110.700 41.496
202503 -14.010 111.100 -14.212
202506 37.580 111.700 37.916
202509 47.700 112.000 47.998
202512 61.420 113.000 61.257
202603 1.710 112.700 1.710

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of 円162.51 mean?
Ono Pharmaceutical Co (TSE:4528) has a E10 of 円162.51 as of Mar. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Ono Pharmaceutical Co and its competitors.
Is Ono Pharmaceutical Co's E10 too high?
Ono Pharmaceutical Co's current E10 is 円162.51. Overall, Ono Pharmaceutical Co has a GF Score™ of 88/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Ono Pharmaceutical Co's E10 compare to LLY and JNJ?
Ono Pharmaceutical Co's E10 of 円162.51 can be compared against companies in the Drug Manufacturers industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Drug Manufacturers company?
A good E10 depends on the Drug Manufacturers industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Ono Pharmaceutical Co and its competitors. Ono Pharmaceutical Co's current E10 is 円162.51. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Ono Pharmaceutical Co stock overvalued right now?
Based on GuruFocus' analysis, Ono Pharmaceutical Co (TSE:4528) is currently considered Fairly Valued. The stock's GF Value™ is 円2,255.53, compared to a current price of 円2,377.50 — trading 5.4% above its estimated fair value. The current E10 is 円162.51. Ono Pharmaceutical Co's overall GF Score™ is 88/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Ono Pharmaceutical Co (TSE:4528), the current E10 is 円162.51 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Ono Pharmaceutical Co (TSE:4528) Overvalued in 2026?

Based on GuruFocus' analysis, Ono Pharmaceutical Co stock appears to be overvalued. The current stock price of 円2,377.50 is trading 5.4% above its estimated GF Value™ of 円2,255.53. GuruFocus considers Ono Pharmaceutical Co to be Fairly Valued.

Key valuation signals for TSE:4528:

  • E10: 円162.51
  • GF Value™: 円2,255.53 vs. price of 円2,377.50 (5.4% above fair value)
  • GF Score™: 88/100 with 2 warning signs

No single metric tells the full story. See the TSE:4528 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Ono Pharmaceutical Co Business Description

Other Exchanges OPHLY:USAON4:Germany
Address 1-8-2 Kyutarocho, Chuo-ku, Osaka, JPN, 541-8564
Ono Pharmaceutical Co Ltd is a drug manufacturer with a focus on drug discovery in areas of unmet medical needs. The vast majority of the company's revenue is derived from its circulatory and respiratory drugs, followed by its metabolic drugs and vitamins. The company also reports revenue derived from royalties. The bulk of the company's sales is generated in Japan, followed by the rest of Asia and Europe.
88GF Score

Get the complete analysis for TSE:4528

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円2,377.50
Price
円2,255.53
GF Value