WAVE Life Sciences (FRA:1U5) E10: €-2.67 (As of Mar. 2026)


FRA:1U5 WAVE Life Sciences Ltd FRA:1U5
59 GF Score
Price €4.86
GF Value €3.80
Valuation Significantly Overvalued
! 2 Warning Signs
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What is WAVE Life Sciences E10?

WAVE Life Sciences FRA:1U5 +2.97% 59 E10 is €-2.67 as of Mar. 2026. GuruFocus rates FRA:1U5 with a GF Score™ of 59/100 and a GF Value™ of €3.80 (Significantly Overvalued). The stock has 2 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

WAVE Life Sciences's adjusted earnings per share data for the three months ended in Mar. 2026 was €-0.112. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is €-2.67 for the trailing ten years ended in Mar. 2026.

Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

As of today (2026-06-30), WAVE Life Sciences's current stock price is €4.86. WAVE Life Sciences's E10 for the quarter that ended in Mar. 2026 was €-2.67. WAVE Life Sciences's Shiller PE Ratio of today is .


WAVE Life Sciences  (FRA:1U5) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


WAVE Life Sciences E10 Related Terms


WAVE Life Sciences E10 Historical Data

* Premium members only.

The historical data trend for WAVE Life Sciences's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

WAVE Life Sciences E10 Chart

WAVE Life Sciences Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 -3.35 -3.04

WAVE Life Sciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -3.27 -2.90 -2.76 -3.04 -2.67

FRA:1U5 vs CGEM, LXRX, XNCR: E10 Comparison

For the Biotechnology subindustry, WAVE Life Sciences's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


WAVE Life Sciences Shiller PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, WAVE Life Sciences's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where WAVE Life Sciences's Shiller PE Ratio falls into.


FRA:1U5
59GF Score
WAVE Life Sciences Ltd FRA:1U5
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

WAVE Life Sciences E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, WAVE Life Sciences's adjusted earnings per share data for the three months ended in Mar. 2026 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Mar. 2026 (Change)*Current CPI (Mar. 2026)
=-0.112/330.2130*330.2130
=-0.112

Current CPI (Mar. 2026) = 330.2130.

WAVE Life Sciences Quarterly Data

per share eps CPI Adj_EPS
201606 -0.454 241.018 -0.622
201609 -0.668 241.428 -0.914
201612 -0.758 241.432 -1.037
201703 -0.841 243.801 -1.139
201706 -0.810 244.955 -1.092
201709 -0.772 246.819 -1.033
201712 -0.946 246.524 -1.267
201803 -1.022 249.554 -1.352
201806 -1.053 251.989 -1.380
201809 -1.097 252.439 -1.435
201812 -1.125 251.233 -1.479
201903 -1.204 254.202 -1.564
201906 -1.080 256.143 -1.392
201909 -1.344 256.759 -1.728
201912 -1.485 256.974 -1.908
202003 -1.249 258.115 -1.598
202006 -1.021 257.797 -1.308
202009 -0.730 260.280 -0.926
202012 -0.485 260.474 -0.615
202103 -0.722 264.877 -0.900
202106 -0.647 271.696 -0.786
202109 -0.102 274.310 -0.123
202112 -0.540 278.802 -0.640
202203 -0.563 287.504 -0.647
202206 -0.587 296.311 -0.654
202209 -0.424 296.808 -0.472
202212 -0.444 296.797 -0.494
202303 -0.252 301.836 -0.276
202306 -0.185 305.109 -0.200
202309 0.066 307.789 0.071
202312 -0.138 306.746 -0.149
202403 -0.221 312.332 -0.234
202406 -0.232 314.175 -0.244
202409 -0.423 315.301 -0.443
202412 0.162 315.605 0.169
202503 -0.268 319.799 -0.277
202506 -0.269 322.561 -0.275
202509 -0.273 324.800 -0.278
202512 -0.256 324.054 -0.261
202603 -0.112 330.213 -0.112

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of €-2.67 mean?
WAVE Life Sciences (FRA:1U5) has a E10 of €-2.67 as of Mar. 2026. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on WAVE Life Sciences and its competitors.
Is WAVE Life Sciences' E10 too high?
WAVE Life Sciences' current E10 is €-2.67. Overall, WAVE Life Sciences has a GF Score™ of 59/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does WAVE Life Sciences' E10 compare to CGEM and LXRX?
WAVE Life Sciences' E10 of €-2.67 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Biotechnology company?
A good E10 depends on the Biotechnology industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on WAVE Life Sciences and its competitors. WAVE Life Sciences's current E10 is €-2.67. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is WAVE Life Sciences stock overvalued right now?
Based on GuruFocus' analysis, WAVE Life Sciences (FRA:1U5) is currently considered Significantly Overvalued. The stock's GF Value™ is €3.80, compared to a current price of €4.86 — trading 27.9% above its estimated fair value. The current E10 is €-2.67. WAVE Life Sciences' overall GF Score™ is 59/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For WAVE Life Sciences (FRA:1U5), the current E10 is €-2.67 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is WAVE Life Sciences (FRA:1U5) Overvalued in 2026?

Based on GuruFocus' analysis, WAVE Life Sciences stock appears to be overvalued. The current stock price of €4.86 is trading 27.9% above its estimated GF Value™ of €3.80. GuruFocus considers WAVE Life Sciences to be Significantly Overvalued.

Key valuation signals for FRA:1U5:

  • E10: €-2.67
  • GF Value™: €3.80 vs. price of €4.86 (27.9% above fair value)
  • GF Score™: 59/100 with 2 warning signs

No single metric tells the full story. See the FRA:1U5 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


WAVE Life Sciences Business Description

Other Exchanges WVE:USA1U5:Germany
Address 7 Straits View No. 12-00, Marina One East Tower, Singapore, SGP, 018936
WAVE Life Sciences Ltd is a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines also known as oligonucleotides, targeting ribonucleic acid (RNA), to transform human health. RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Its toolkit of RNA-targeting modalities includes RNA editing, antisense silencing, and RNA interference, providing capabilities for designing and sustainably delivering candidates that optimally address disease biology. Its programs are for rare and prevalent diseases, including alpha-1 antitrypsin deficiency, obesity, Duchenne muscular dystrophy, and Huntington's disease.
59GF Score

Get the complete analysis for FRA:1U5

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

€4.86
Price
€3.80
GF Value