Chiome Bioscience (TSE:4583) E10: 円-43.42 (As of Dec. 2025)

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TSE:4583 Chiome Bioscience Inc TSE:4583
38 GF Score
Price 円69.00
GF Value 円106.02
Valuation Possible Value Trap
! 1 Warning Sign
View Full Analysis

What is Chiome Bioscience E10?

Chiome Bioscience TSE:4583 -1.43% 38 E10 is 円-43.42 as of Dec. 2025. GuruFocus rates TSE:4583 with a GF Score™ of 38/100 and a GF Value™ of 円106.02 (Possible Value Trap). The stock has 1 warning sign investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years.

Chiome Bioscience's adjusted earnings per share data for the three months ended in Dec. 2025 was 円-5.750. Add all the adjusted EPS for the past 10 years together and divide 10 will get our e10, which is 円-43.42 for the trailing ten years ended in Dec. 2025.

During the past 3 years, the average E10 Growth Rate was 3.00% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the E10 growth rate using E10 data.

During the past 13 years, the highest 3-Year average E10 Growth Rate of Chiome Bioscience was 3.00% per year. The lowest was 3.00% per year. And the median was 3.00% per year.

As of today (2026-07-25), Chiome Bioscience's current stock price is 円69.00. Chiome Bioscience's E10 for the quarter that ended in Dec. 2025 was 円-43.42. Chiome Bioscience's Shiller PE Ratio of today is .


Chiome Bioscience  (TSE:4583) E10 Explanation

If a company grows much fast than inflation, E10 may underestimate the company's earnings power. Shiller PE Ratio can seem to be too high even the actual P/E is low.

For the Shiller P/E, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller P/E is also called PE10.

The Shiller P/E was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.


Be Aware

Shiller PE Ratio works better for cyclical companies. It gives you a better idea on the company's real earnings power.


Chiome Bioscience E10 Related Terms


Chiome Bioscience E10 Historical Data

* Premium members only.

The historical data trend for Chiome Bioscience's E10 can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Chiome Bioscience E10 Chart

Chiome Bioscience Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
E10
Get a 7-Day Free Trial Premium Member Only Premium Member Only -45.48 -47.54 -47.53 0.00 -43.42

Chiome Bioscience Quarterly Data
Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
E10 Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -45.62 -44.42 0.00 -43.42 0.00

TSE:4583 vs VRTX, REGN, ALNY: E10 Comparison

For the Biotechnology subindustry, Chiome Bioscience's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Chiome Bioscience Shiller PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Chiome Bioscience's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Chiome Bioscience's Shiller PE Ratio falls into.


TSE:4583
38GF Score
Chiome Bioscience Inc TSE:4583
E10 is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Chiome Bioscience E10 Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller P/E calculation. When we calculate the today's Shiller P/E ratio of a stock, we use today's price divided by E10.

What is E10? How do we calculate E10?

E10 is the average of the inflation adjusted earnings of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the E10 of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the earnings from 2001 through 2010.

We adjusted the earnings of 2001 earnings data with the total inflation from 2001 through 2010 to the equivalent earnings in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart earned $1 a share in 2001, then the 2001's equivalent earnings in 2010 is $1.4 a share. If Wal-Mart earns $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 earnings in 2010 is $1.35. So on and so forth, you get the equivalent earnings of past 10 years. Then you add them together and divided the sum by 10 to get E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, Chiome Bioscience's adjusted earnings per share data for the three months ended in Dec. 2025 was:

Adj_EPS= Earnings per Share (Diluted) /CPI of Dec. 2025 (Change)*Current CPI (Dec. 2025)
=-5.75/113.0000*113.0000
=-5.750

Current CPI (Dec. 2025) = 113.0000.

Chiome Bioscience Quarterly Data

per share eps CPI Adj_EPS
201512 -15.110 98.100 -17.405
201603 -13.620 97.900 -15.721
201606 -18.370 98.100 -21.160
201609 -11.250 98.000 -12.972
201612 -22.670 98.400 -26.034
201703 -7.930 98.100 -9.134
201706 -7.090 98.500 -8.134
201709 -6.910 98.800 -7.903
201712 -11.560 99.400 -13.142
201803 -11.250 99.200 -12.815
201806 -11.303 99.200 -12.875
201809 -12.080 99.900 -13.664
201812 -22.632 99.700 -25.651
201903 -15.590 99.700 -17.670
201906 -9.955 99.800 -11.272
201909 -12.430 100.100 -14.032
201912 -7.019 100.500 -7.892
202003 -12.780 100.300 -14.398
202006 -9.230 99.900 -10.440
202009 -9.320 99.900 -10.542
202012 -5.212 99.300 -5.931
202103 -4.000 99.900 -4.525
202106 -6.160 99.500 -6.996
202109 -10.780 100.100 -12.169
202112 -15.800 100.100 -17.836
202203 -11.660 101.100 -13.032
202206 -6.510 101.800 -7.226
202209 -5.700 103.100 -6.247
202212 -4.446 104.100 -4.826
202303 -4.700 104.400 -5.087
202306 -9.000 105.200 -9.667
202309 -5.120 106.200 -5.448
202312 -5.800 106.800 -6.137
202403 -5.600 107.200 -5.903
202406 -4.610 108.200 -4.815
202412 0.000 110.700 0.000
202503 -3.940 111.100 -4.007
202506 -4.030 111.700 -4.077
202509 0.000 112.000 0.000
202512 -5.750 113.000 -5.750

Add all the adjusted EPS together and divide 10 will get our e10.

Frequently Asked Questions Learn more about E10 →
What does a E10 of 円-43.42 mean?
Chiome Bioscience (TSE:4583) has a E10 of 円-43.42 as of Dec. 2025. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Chiome Bioscience and its competitors.
Is Chiome Bioscience's E10 too high?
Chiome Bioscience's current E10 is 円-43.42. Overall, Chiome Bioscience has a GF Score™ of 38/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Chiome Bioscience's E10 compare to VRTX and REGN?
Chiome Bioscience's E10 of 円-43.42 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good E10 for a Biotechnology company?
A good E10 depends on the Biotechnology industry context. However, E10 should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high E10 mean?
A high E10 can signal that a stock is expensive relative to its fundamentals. E10 represents the company's inflation-adjusted earnings per share over a 10-year period. View historical data on Chiome Bioscience and its competitors. Chiome Bioscience's current E10 is 円-43.42. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Chiome Bioscience stock overvalued right now?
Based on GuruFocus' analysis, Chiome Bioscience (TSE:4583) is currently considered Possible Value Trap. The stock's GF Value™ is 円106.02, compared to a current price of 円69.00 — trading 34.9% below its estimated fair value. The current E10 is 円-43.42. Chiome Bioscience's overall GF Score™ is 38/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is E10 calculated?
E10 is calculated from a company's financial statements. For Chiome Bioscience (TSE:4583), the current E10 is 円-43.42 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Chiome Bioscience (TSE:4583) Overvalued in 2026?

Based on GuruFocus' analysis, Chiome Bioscience stock appears to be undervalued. The current stock price of 円69.00 is trading 34.9% below its estimated GF Value™ of 円106.02. GuruFocus considers Chiome Bioscience to be Possible Value Trap.

Key valuation signals for TSE:4583:

  • E10: 円-43.42
  • GF Value™: 円106.02 vs. price of 円69.00 (34.9% below fair value)
  • GF Score™: 38/100 with 1 warning sign

No single metric tells the full story. See the TSE:4583 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Chiome Bioscience Business Description

Address 3-12-1 Honmachi, No. 6, Sumitomo Fudosan Nishi Shinjuku Building, Shibuya-ku, Tokyo, JPN, 151-0071
Chiome Bioscience Inc is engaged in the discovery and development of antibody drugs, focusing on early-stage research and initial clinical trials. The company operates through two reportable segments: the Drug Discovery segment and the Drug Discovery Support segment. The Drug Discovery segment conducts research on antibody creation for diseases with high unmet medical needs and aims to generate revenue through licensing agreements, upfront payments, milestone payments, and royalties. The Drug Discovery Support segment provides services such as antibody production and related support using proprietary antibody technologies, catering to pharmaceutical and diagnostic companies as well as academic institutions.
38GF Score

Get the complete analysis for TSE:4583

E10 is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円69.00
Price
円106.02
GF Value