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Chiome BioscienceTSE:4583 42 Cyclically Adjusted PB Ratio is 0.71 as of Aug. 05, 2026, which is 40% below its 10-year median of 1.18. GuruFocus rates TSE:4583 with a GF Score™ of 42/100 and a GF Value™ of 円105.73 (Possible Value Trap). The stock has 2 warning signs investors should review. Among 696 Biotechnology companies, Chiome Bioscience ranks better than 67.82% on this metric.
The historical rank and industry rank for Chiome Bioscience's Cyclically Adjusted PB Ratio or its related term are showing as below:
TSE:4583'
s Cyclically Adjusted PB Ratio Range Over the Past 10 Years
Min: 0.69 Med: 1.18 Max: 2.32
Current: 0.7
During the past years, Chiome Bioscience's highest Cyclically Adjusted PB Ratio was 2.32. The lowest was 0.69. And the median was 1.18.
TSE:4583's Cyclically Adjusted PB Ratio is ranked better than 67.82% of 696
companies
in the Biotechnology industry
Industry Median: 1.585
vs TSE:4583: 0.70
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.
Chiome Bioscience's adjusted book value per share data for the three months ended in Dec. 2025 was 円16.394. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円97.16 for the trailing ten years ended in Dec. 2025.
Shiller PE for Stocks: The True Measure of Stock Valuation
Chiome Bioscience (TSE:4583) Cyclically Adjusted PB Ratio Explanation
Compared with the regular PB Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PB Ratio smoothed out the fluctuations of book value during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PB Ratio should give similar results to regular PB Ratio.
Chiome Bioscience Cyclically Adjusted PB Ratio Related Terms
Chiome Bioscience Cyclically Adjusted PB Ratio Historical Data
* Premium members only.
The historical data trend for Chiome Bioscience's Cyclically Adjusted PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Chiome Bioscience Cyclically Adjusted PB Ratio Chart
TSE:4583 vs VRTX, REGN, RVMD: Cyclically Adjusted PB Ratio Comparison
For the Biotechnology subindustry, Chiome Bioscience's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Chiome Bioscience Cyclically Adjusted PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Chiome Bioscience's Cyclically Adjusted PB Ratio distribution charts can be found below:
* The bar in red indicates where Chiome Bioscience's Cyclically Adjusted PB Ratio falls into.
Chiome Bioscience Cyclically Adjusted PB Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PB Ratio takes the Book Value per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/B calculation. Because it considers this 10-year average, it's often referred to as the CAPB Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio.
Chiome Bioscience's Cyclically Adjusted PB Ratio for today is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PB Ratio of 0.71 mean?
Chiome Bioscience (TSE:4583) has a Cyclically Adjusted PB Ratio of 0.71 as of Aug. 05, 2026. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Chiome Bioscience and its competitors. This is 40% below median its historical median of 1.18. Over the past decade, Chiome Bioscience's Cyclically Adjusted PB Ratio has ranged from 0.69 to 2.32. According to the industry distribution chart, Chiome Bioscience ranks #224 out of 696 companies in the Biotechnology industry, placing it in the top 32.2%.
Is Chiome Bioscience's Cyclically Adjusted PB Ratio too high?
Chiome Bioscience's current Cyclically Adjusted PB Ratio of 0.71 is 40% below median its 10-year median of 1.18. Over the past 10 years, this metric has ranged from a low of 0.69 to a high of 2.32. The Biotechnology industry median Cyclically Adjusted PB Ratio is 1.59. Chiome Bioscience's value of 0.71 is 55.2% below this industry median. Based on the distribution chart, Chiome Bioscience ranks #224 out of 696 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Chiome Bioscience has a GF Score™ of 42/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Chiome Bioscience's Cyclically Adjusted PB Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Chiome Bioscience ranks #224 out of 696 companies for Cyclically Adjusted PB Ratio. This puts Chiome Bioscience in the upper half of its industry. The industry median Cyclically Adjusted PB Ratio is 1.59. Chiome Bioscience's value of 0.71 is 55.2% below this benchmark. Historically, Chiome Bioscience's own Cyclically Adjusted PB Ratio has ranged from 0.69 to 2.32 over the past decade. While the company's 10-year median is 1.18 vs. the industry median of 1.59, Chiome Bioscience has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PB Ratio for a Biotechnology company?
The median Cyclically Adjusted PB Ratio among Biotechnology companies is 1.59, based on 696 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Chiome Bioscience's current Cyclically Adjusted PB Ratio of 0.71 is 55.2% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PB Ratio mean?
A high Cyclically Adjusted PB Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PB Ratio is the ratio of share price to a company's inflation-adjusted book value per share over a 10-year period. View historical data on Chiome Bioscience and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PB Ratio is 1.59 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Chiome Bioscience's current Cyclically Adjusted PB Ratio is 0.71, which is 40% below median its own 10-year median of 1.18. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Chiome Bioscience stock overvalued right now?
Based on GuruFocus' analysis, Chiome Bioscience (TSE:4583) is currently considered Possible Value Trap. The stock's GF Value™ is 円105.73, compared to a current price of 円69.00 — trading 34.7% below its estimated fair value. The current Cyclically Adjusted PB Ratio is 0.71, which is 40% below median its 10-year median of 1.18 and 55.2% below the Biotechnology industry median of 1.59. Chiome Bioscience's overall GF Score™ is 42/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PB Ratio calculated?
Cyclically Adjusted PB Ratio is calculated from a company's financial statements. For Chiome Bioscience (TSE:4583), the current Cyclically Adjusted PB Ratio is 0.71 as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Chiome Bioscience (TSE:4583) Overvalued in 2026?
Based on GuruFocus' analysis, Chiome Bioscience stock appears to be undervalued.
The current stock price of 円69.00 is trading 34.7% below its estimated GF Value™ of 円105.73.
GuruFocus considers Chiome Bioscience to be Possible Value Trap.
Key valuation signals for TSE:4583:
Cyclically Adjusted PB Ratio: 0.71 (40% below median its 10-year median of 1.18)
GF Value™: 円105.73 vs. price of 円69.00 (34.7% below fair value)
Industry Position: 55.2% below the Biotechnology median (#224 of 696)
No single metric tells the full story. See the TSE:4583 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Chiome Bioscience Inc is engaged in the discovery and development of antibody drugs, focusing on early-stage research and initial clinical trials. The company operates through two reportable segments: the Drug Discovery segment and the Drug Discovery Support segment. The Drug Discovery segment conducts research on antibody creation for diseases with high unmet medical needs and aims to generate revenue through licensing agreements, upfront payments, milestone payments, and royalties. The Drug Discovery Support segment provides services such as antibody production and related support using proprietary antibody technologies, catering to pharmaceutical and diagnostic companies as well as academic institutions.
42GF Score
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