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Xilio TherapeuticsXLO +0.52%32 Earnings Yield (Joel Greenblatt) % is 46.95% as of Jun. 2026, which is 44% below its 10-year median of 83.81. GuruFocus rates XLO with a GF Score™ of 32/100. The stock has 2 warning signs investors should review. Among 1,341 Biotechnology companies, Xilio Therapeutics ranks worse than 74571.14% on this metric.
Xilio Therapeutics's Enterprise Value for the quarter that ended in Jun. 2026 was $-66.70 Mil.
Xilio Therapeutics's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 was $-31.37 Mil. Xilio Therapeutics's Earnings Yield (Joel Greenblatt) for the quarter that ended in Jun. 2026 was 46.95%.
The historical rank and industry rank for Xilio Therapeutics's Earnings Yield (Joel Greenblatt) % or its related term are showing as below:
XLO'
s Earnings Yield (Joel Greenblatt) % Range Over the Past 10 Years
Min: -5119.99 Med: 83.81 Max: 45239.87
Current: 44.44
During the past 7 years, the highest Earnings Yield (Joel Greenblatt) of Xilio Therapeutics was 45239.87%. The lowest was -5119.99%. And the median was 83.81%.
XLO's Earnings Yield (Joel Greenblatt) % is not ranked
in the Biotechnology industry.
Industry Median: -10
vs XLO: 44.44
Joel Greenblatt's definition of earnings yield has the same problems the regular earnings yield does. It does not consider the growth of the company. It only looks at one-year's business operation. For cyclical companies, the earnings yield is usually highest at the peak of the business cycle. But these earnings are rarely sustainable.
A better indicator of the attractiveness of an investment which takes growth into account is the Forward Rate of Return (Yacktman) %. Xilio Therapeutics's Forward Rate of Return (Yacktman) % for the quarter that ended in Jun. 2026 was 0.00%. The Forward Rate of Return uses the normalized Free Cash Flow of the past five years, and considers growth. The forward rate of return can be thought of as the return that investors buying the stock today can expect from it in the future.
Joel Greenblatt defines the earnings yield using the above equation because it more accurately reflects the company's profitability relative to its stock price. Items like interest payment and tax etc. are not directly related to the company's operational profitability.
Enterprise Value instead of market cap (share price) is used in the calculation because it is the real price stock and bond investors together pay for the company.
Be Aware
Joel Greenblatt's definition of earnings yield has the same problems the regular earnings yield does. It does not consider the growth of the company. It only looks at one-year's business operation. For cyclical companies, the earnings yield is usually highest at the peak of the business cycle. But these earnings are rarely sustainable.
Xilio Therapeutics Earnings Yield (Joel Greenblatt) % Related Terms
Xilio Therapeutics Earnings Yield (Joel Greenblatt) % Historical Data
* Premium members only.
The historical data trend for Xilio Therapeutics's Earnings Yield (Joel Greenblatt) % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Xilio Therapeutics's Earnings Yield (Joel Greenblatt) %, along with its competitors' market caps and Earnings Yield (Joel Greenblatt) % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Xilio Therapeutics Earnings Yield (Joel Greenblatt) % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Xilio Therapeutics's Earnings Yield (Joel Greenblatt) % distribution charts can be found below:
* The bar in red indicates where Xilio Therapeutics's Earnings Yield (Joel Greenblatt) % falls into.
In his book, The Little That Beat the Market, hedge fund manager Joel Greenblatt defines Earnings Yield as operating income divided by enterprise value.
Xilio Therapeuticss Earnings Yield (Joel Greenblatt) for the fiscal year that ended in Dec. 2025 is calculated as
Xilio Therapeutics's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-31.37 Mil.
What does a Earnings Yield (Joel Greenblatt) % of 46.95% mean?
Xilio Therapeutics (XLO) has a Earnings Yield (Joel Greenblatt) % of 46.95% as of Jun. 2026. Joel Greenblatt's earnings yield equals the ratio of earnings before interest and taxes to enterprise value. View historical data on Xilio Therapeutics and its competitors. This is 44% below median its historical median of 83.81. According to the industry distribution chart, Xilio Therapeutics ranks #999999 out of 1341 companies in the Biotechnology industry.
Is Xilio Therapeutics' Earnings Yield (Joel Greenblatt) % too high?
Xilio Therapeutics' current Earnings Yield (Joel Greenblatt) % of 46.95% is 44% below median its 10-year median of 83.81. Based on the distribution chart, Xilio Therapeutics ranks #999999 out of 1341 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Xilio Therapeutics has a GF Score™ of 32/100, reflecting its overall financial health beyond just this single metric.
How does Xilio Therapeutics' Earnings Yield (Joel Greenblatt) % compare to INKT and IMA?
According to the Biotechnology industry distribution chart, Xilio Therapeutics ranks #999999 out of 1341 companies for Earnings Yield (Joel Greenblatt) %. This places Xilio Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Earnings Yield (Joel Greenblatt) % for a Biotechnology company?
A good Earnings Yield (Joel Greenblatt) % depends on the Biotechnology industry context. However, Earnings Yield (Joel Greenblatt) % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Earnings Yield (Joel Greenblatt) % mean?
A high Earnings Yield (Joel Greenblatt) % can signal that a stock is expensive relative to its fundamentals. Joel Greenblatt's earnings yield equals the ratio of earnings before interest and taxes to enterprise value. View historical data on Xilio Therapeutics and its competitors. Xilio Therapeutics's current Earnings Yield (Joel Greenblatt) % is 46.95%, which is 44% below median its own 10-year median of 83.81. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Xilio Therapeutics stock overvalued right now?
Xilio Therapeutics (XLO) has a current Earnings Yield (Joel Greenblatt) % of 46.95%. The current Earnings Yield (Joel Greenblatt) % is 46.95%, which is 44% below median its 10-year median of 83.81. Xilio Therapeutics' overall GF Score™ is 32/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Earnings Yield (Joel Greenblatt) % calculated?
Earnings Yield (Joel Greenblatt) % is calculated from a company's financial statements. For Xilio Therapeutics (XLO), the current Earnings Yield (Joel Greenblatt) % is 46.95% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Xilio Therapeutics Inc is a clinical-stage biotechnology company focused on discovering and developing masked immuno-oncology (I-O) therapies to improve outcomes for people living with cancer. Leveraging its clinically validated masking technology and capabilities, the company develops I-O therapies designed to selectively activate within the tumor microenvironment to achieve durable efficacy without the severe side effects associated with systemically active I-O agents. Its integrated biology and protein engineering approach enables the design and development of potent masked biologics that are activated by tumor-specific proteases.
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