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Xilio TherapeuticsXLO +0.52%32 12-1 Month Momentum % is -9.57% as of Sep. 05, 2026. GuruFocus rates XLO with a GF Score™ of 32/100. The stock has 2 warning signs investors should review. Among 1,355 Biotechnology companies, Xilio Therapeutics ranks better than 59.56% on this metric.
12-1 Month Momentum % is the total return of the stock from 12-month ago to 1-month ago. As of today (2026-09-05), Xilio Therapeutics's 12-1 Month Momentum % is -9.57%.
The industry rank for Xilio Therapeutics's 12-1 Month Momentum % or its related term are showing as below:
XLO's 12-1 Month Momentum % is ranked better than 59.56% of 1355
companies
in the Biotechnology industry
Industry Median: -22.94
vs XLO: -9.57
Momentum investing is a trading strategy in which investors buy securities that are rising and sell before the prices start to go back down. The 12-1 Month Momentum % measures the total return to a stock over the past twelve months, but ignores the previous month.
The reason why the most recent month’s return dropped related to the short-term reversal effect associated with momentum. There is an academic finding that short-term momentum actually has a reversal effect, whereby the previous winners (measured over the past months) do poorly the next month, while the previous losers do well the next month. In order to eliminate the short-term reversal effect, the previous month return was not included in this calculation.
Xilio Therapeutics 12-1 Month Momentum % Related Terms
XLO vs INKT, IMA, HRTX: 12-1 Month Momentum % Comparison
For the Biotechnology subindustry, Xilio Therapeutics's 12-1 Month Momentum %, along with its competitors' market caps and 12-1 Month Momentum % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Xilio Therapeutics 12-1 Month Momentum % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Xilio Therapeutics's 12-1 Month Momentum % distribution charts can be found below:
* The bar in red indicates where Xilio Therapeutics's 12-1 Month Momentum % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Xilio Therapeutics (XLO) has a 12-1 Month Momentum % of -9.57% as of Sep. 05, 2026. 12-1 Month Momentum measures the total return of the stock from 12-month ago to 1-month ago. View historical data on Xilio Therapeutics and its competitors. According to the industry distribution chart, Xilio Therapeutics ranks #548 out of 1355 companies in the Biotechnology industry, placing it in the top 40.4%.
Is Xilio Therapeutics' 12-1 Month Momentum % too high?
Xilio Therapeutics' current 12-1 Month Momentum % is -9.57%. Based on the distribution chart, Xilio Therapeutics ranks #548 out of 1355 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Xilio Therapeutics has a GF Score™ of 32/100, reflecting its overall financial health beyond just this single metric.
How does Xilio Therapeutics' 12-1 Month Momentum % compare to INKT and IMA?
According to the Biotechnology industry distribution chart, Xilio Therapeutics ranks #548 out of 1355 companies for 12-1 Month Momentum %. This puts Xilio Therapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 12-1 Month Momentum % for a Biotechnology company?
A good 12-1 Month Momentum % depends on the Biotechnology industry context. However, 12-1 Month Momentum % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 12-1 Month Momentum % mean?
A high 12-1 Month Momentum % can signal that a stock is expensive relative to its fundamentals. 12-1 Month Momentum measures the total return of the stock from 12-month ago to 1-month ago. View historical data on Xilio Therapeutics and its competitors. Xilio Therapeutics's current 12-1 Month Momentum % is -9.57%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Xilio Therapeutics stock overvalued right now?
Xilio Therapeutics (XLO) has a current 12-1 Month Momentum % of -9.57%. The current 12-1 Month Momentum % is -9.57%. Xilio Therapeutics' overall GF Score™ is 32/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 12-1 Month Momentum % calculated?
12-1 Month Momentum % is calculated from a company's financial statements. For Xilio Therapeutics (XLO), the current 12-1 Month Momentum % is -9.57% as of Sep. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Xilio Therapeutics Inc is a clinical-stage biotechnology company focused on discovering and developing masked immuno-oncology (I-O) therapies to improve outcomes for people living with cancer. Leveraging its clinically validated masking technology and capabilities, the company develops I-O therapies designed to selectively activate within the tumor microenvironment to achieve durable efficacy without the severe side effects associated with systemically active I-O agents. Its integrated biology and protein engineering approach enables the design and development of potent masked biologics that are activated by tumor-specific proteases.
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