PRLD (Prelude Therapeutics) EV-to-EBIT: -3.89 (As of Jul. 09, 2026)


PRLD Prelude Therapeutics Inc PRLD
26 GF Score
Price $4.91
! 6 Warning Signs
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What is Prelude Therapeutics EV-to-EBIT?

Prelude Therapeutics PRLD -4.29% 26 EV-to-EBIT is -3.89 as of Jul. 09, 2026. GuruFocus rates PRLD with a GF Score™ of 26/100. The stock has 6 warning signs investors should review. Among 366 Biotechnology companies, Prelude Therapeutics ranks worse than 273223.77% on this metric.

EV-to-EBIT is calculated as Enterprise Value divided by its EBIT. As of today, Prelude Therapeutics's Enterprise Value is $327.23 Mil. Prelude Therapeutics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was $-84.14 Mil. Therefore, Prelude Therapeutics's EV-to-EBIT for today is -3.89.

The historical rank and industry rank for Prelude Therapeutics's EV-to-EBIT or its related term are showing as below:

PRLD' s EV-to-EBIT Range Over the Past 10 Years
Min: -4.27   Med: -0.14   Max: 0.52
Current: -3.89

During the past 8 years, the highest EV-to-EBIT of Prelude Therapeutics was 0.52. The lowest was -4.27. And the median was -0.14.

PRLD's EV-to-EBIT is ranked worse than
100% of 366 companies
in the Biotechnology industry
Industry Median: 14.625 vs PRLD: -3.89

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %. Prelude Therapeutics's Enterprise Value for the quarter that ended in Mar. 2026 was $151.69 Mil. Prelude Therapeutics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was $-84.14 Mil. Prelude Therapeutics's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Mar. 2026 was -55.47%.


Prelude Therapeutics  (NAS:PRLD) EV-to-EBIT Explanation

This is a more accurate valuation of companies' operation because it considers the debt and cash on its balance sheet, and non-operating items such as interest payment, tax, and one-time items are not included in the Operating Income.

Joel Greenblatt calls the inversion of this ratio Earnings Yield (Joel Greenblatt) %.

Prelude Therapeutics's Earnings Yield (Joel Greenblatt) % for the quarter that ended in Mar. 2026 is calculated as:

Earnings Yield (Joel Greenblatt) % (Q: Mar. 2026 ) =EBIT / Enterprise Value (Q: Mar. 2026 )
=-84.137/151.68856
=-55.47 %

Prelude Therapeutics's Enterprise Value for the quarter that ended in Mar. 2026 was $151.69 Mil.
Prelude Therapeutics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-84.14 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Prelude Therapeutics EV-to-EBIT Related Terms


Prelude Therapeutics EV-to-EBIT Historical Data

* Premium members only.

The historical data trend for Prelude Therapeutics's EV-to-EBIT can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Prelude Therapeutics EV-to-EBIT Chart

Prelude Therapeutics Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
EV-to-EBIT
Get a 7-Day Free Trial -2.67 -0.72 -0.14 0.32 -0.93

Prelude Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
EV-to-EBIT Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.27 0.07 -0.37 -0.93 -1.80

PRLD vs DMAC, RCKT, CYDY: EV-to-EBIT Comparison

For the Biotechnology subindustry, Prelude Therapeutics's EV-to-EBIT, along with its competitors' market caps and EV-to-EBIT data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Prelude Therapeutics EV-to-EBIT vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Prelude Therapeutics's EV-to-EBIT distribution charts can be found below:

* The bar in red indicates where Prelude Therapeutics's EV-to-EBIT falls into.


PRLD
26GF Score
Prelude Therapeutics Inc PRLD
EV-to-EBIT is just one metric. See GF Score™, valuation, warning signs, and more.
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Prelude Therapeutics EV-to-EBIT Calculation

Prelude Therapeutics's EV-to-EBIT for today is calculated as:

EV-to-EBIT=Enterprise Value (Today)/EBIT (TTM)
=327.225/-84.137
=-3.89

Prelude Therapeutics's current Enterprise Value is $327.23 Mil.
Prelude Therapeutics's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-84.14 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about EV-to-EBIT →
What does a EV-to-EBIT of -3.89 mean?
Prelude Therapeutics (PRLD) has a EV-to-EBIT of -3.89 as of Jul. 09, 2026. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Prelude Therapeutics and its competitors. According to the industry distribution chart, Prelude Therapeutics ranks #999999 out of 366 companies in the Biotechnology industry.
Is Prelude Therapeutics' EV-to-EBIT too high?
Prelude Therapeutics' current EV-to-EBIT is -3.89. Based on the distribution chart, Prelude Therapeutics ranks #999999 out of 366 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Prelude Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Prelude Therapeutics' EV-to-EBIT compare to DMAC and RCKT?
According to the Biotechnology industry distribution chart, Prelude Therapeutics ranks #999999 out of 366 companies for EV-to-EBIT. This places Prelude Therapeutics in the lower half of its industry. The industry median EV-to-EBIT is 14.63. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBIT for a Biotechnology company?
The median EV-to-EBIT among Biotechnology companies is 14.63, based on 366 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBIT significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBIT should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBIT mean?
A high EV-to-EBIT can signal that a stock is expensive relative to its fundamentals. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Prelude Therapeutics and its competitors. For the Biotechnology industry, the median EV-to-EBIT is 14.63 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Prelude Therapeutics's current EV-to-EBIT is -3.89. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prelude Therapeutics stock overvalued right now?
Prelude Therapeutics (PRLD) has a current EV-to-EBIT of -3.89. The current EV-to-EBIT is -3.89. Prelude Therapeutics' overall GF Score™ is 26/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBIT calculated?
EV-to-EBIT is calculated from a company's financial statements. For Prelude Therapeutics (PRLD), the current EV-to-EBIT is -3.89 as of Jul. 09, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Prelude Therapeutics Business Description

Address 175 Innovation Boulevard, Wilmington, DE, USA, 19805
Prelude Therapeutics Incorp is a precision oncology company developing medicines in areas of high unmet need for cancer patients. Its pipeline features selective KAT6A degraders and mutant selective JAK2V617F JH2 inhibitors, new approaches to clinically validated targets with transformative potential for patients. The company is also leveraging its expertise in targeted protein degradation to discover and develop next-generation degrader antibody conjugates (DACs) with novel payloads.
26GF Score

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EV-to-EBIT is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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