Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Zentalis PharmaceuticalsZNTL 32 Piotroski F-Score is 2 as of Aug. 23, 2026, which is at its 10-year median of 2.00. GuruFocus rates ZNTL with a GF Score™ of 32/100. The stock has 3 warning signs investors should review. Among 1,340 Biotechnology companies, Zentalis Pharmaceuticals ranks worse than 73.58% on this metric.
Warning Sign:
Piotroski F-Score of 2 is low, which usually implies poor business operation.
The zones of discrimination were as such:
Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Zentalis Pharmaceuticals has an F-score of 2. It is a bad or low score, which usually implies poor business operation.
The historical rank and industry rank for Zentalis Pharmaceuticals's Piotroski F-Score or its related term are showing as below:
ZNTL'
s Piotroski F-Score Range Over the Past 10 Years
Min: 1 Med: 2 Max: 6
Current: 2
During the past 8 years, the highest Piotroski F-Score of Zentalis Pharmaceuticals was 6. The lowest was 1. And the median was 2.
The developer of the system is Joseph D. Piotroski is relatively unknown accounting professor who shuns publicity and rarely gives interviews.
He graduated from the University of Illinois with a B.S. in accounting in 1989, received an M.B.A. from Indiana University in 1994. Five years later, in 1999, after earning a Ph.D. in accounting from the University of Michigan, he became an associate professor of accounting at the University of Chicago.
He wanted to see if he can develop a system (using a simple nine-point scoring system) that can increase the returns of a strategy of investing in low price to book (referred to in the paper as high book to market) value companies.
What he found was something that exceeded his most optimistic expectations.
Buying only those companies that scored highest (8 or 9) on his nine-point scale, or F-Score as he called it, over the 20 year period from 1976 to 1996 led to an average out-performance over the market of 13.4%.
Even more impressive were the results of a strategy of investing in the highest F-Score companies (8 or 9) and shorting companies with the lowest F-Score (0 or 1).
Over the same period from 1976 to 1996 (20 years) this strategy led to an average yearly return of 23%, substantially outperforming the average S&P 500 index return of 15.83% over the same period.
Zentalis Pharmaceuticals Piotroski F-Score Related Terms
Zentalis Pharmaceuticals Piotroski F-Score Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ZNTL vs PROK, LYEL, PRLD: Piotroski F-Score Comparison
For the Biotechnology subindustry, Zentalis Pharmaceuticals's Piotroski F-Score, along with its competitors' market caps and Piotroski F-Score data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Zentalis Pharmaceuticals Piotroski F-Score vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Zentalis Pharmaceuticals's Piotroski F-Score distribution charts can be found below:
* The bar in red indicates where Zentalis Pharmaceuticals's Piotroski F-Score falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
*Note: If the latest quarterly/semi-annual/annual total assets data is 0, then we will use previous quarterly/semi-annual/annual data for all the items in the balance sheet.
Profitability
Question 1. Return on Assets (ROA)
Net income before extraordinary items for the year divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Zentalis Pharmaceuticals's current Net Income (TTM) was -139.55.
==> Negative ==> Score 0.
Question 2. Cash Flow Return on Assets (CFROA)
Net cash flow from operating activities (operating cash flow) divided by Total Assets at the beginning of the year.
Score 1 if positive, 0 if negative.
Zentalis Pharmaceuticals's current Cash Flow from Operations (TTM) was -128.10.
==> Negative ==> Score 0.
Question 3. Change in Return on Assets
Compare this year's return on assets (1) to last year's return on assets.
Zentalis Pharmaceuticals's return on assets of this year was -0.39676492. Zentalis Pharmaceuticals's return on assets of last year was -0.33107509.
==> Last year is higher ==> Score 0.
Question 4. Quality of Earnings (Accrual)
Compare Cash flow return on assets (2) to return on assets (1)
Zentalis Pharmaceuticals's gearing of this year was 0.11681937. Zentalis Pharmaceuticals's gearing of last year was 0.08938032.
==> Last year is lower than this year ==> Score 0.
Question 6. Change in Working Capital (Liquidity)
Compare this year's current ratio (current assets divided by current liabilities) to last year's current ratio.
Score 1 if this year's current ratio is higher, 0 if it's lower
Zentalis Pharmaceuticals's current ratio of this year was 4.81791846. Zentalis Pharmaceuticals's current ratio of last year was 7.98513659.
==> Last year's current ratio is higher ==> Score 0.
Question 7. Change in Shares in Issue
Compare the number of shares in issue this year, to the number in issue last year.
Score 0 if there is larger number of shares in issue this year, 1 otherwise.
Zentalis Pharmaceuticals's number of shares in issue this year was 71.326. Zentalis Pharmaceuticals's number of shares in issue last year was 71.992.
==> There is smaller number of shares in issue this year, or the same. ==> Score 1.
Efficiency
Question 8. Change in Gross Margin
Compare this year's gross margin (Gross Profit divided by sales) to last year's.
Score 1 if this year's gross margin is higher, 0 if it's lower.
Zentalis Pharmaceuticals's gross margin of this year was . Zentalis Pharmaceuticals's gross margin of last year was 1.
==> Last year's gross margin is higher ==> Score 0.
Question 9. Change in asset turnover
Compare this year's asset turnover (total sales for the year divided by total assets at the beginning of the year) to last year's asset turnover ratio.
Score 1 if this year's asset turnover ratio is higher, 0 if it's lower
Zentalis Pharmaceuticals's asset turnover of this year was 0. Zentalis Pharmaceuticals's asset turnover of last year was 0.0546392.
==> Last year's asset turnover is higher ==> Score 0.
Evaluation
Piotroski F-Score
=
Que. 1
+
Que. 2
+
Que. 3
+
Que. 4
+
Que. 5
+
Que. 6
+
Que. 7
+
Que. 8
+
Que. 9
=
0
+
0
+
0
+
1
+
0
+
0
+
1
+
0
+
0
=
2
Good or high score = 7, 8, 9
Bad or low score = 0, 1, 2, 3
Zentalis Pharmaceuticals has an F-score of 2. It is a bad or low score, which usually implies poor business operation.
Zentalis Pharmaceuticals (ZNTL) has a Piotroski F-Score of 2 as of Aug. 23, 2026. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Zentalis Pharmaceuticals and its competitors. This is near median its historical median of 2.00. Over the past decade, Zentalis Pharmaceuticals' Piotroski F-Score has ranged from 1.00 to 6.00. According to the industry distribution chart, Zentalis Pharmaceuticals ranks #986 out of 1340 companies in the Biotechnology industry, placing it in the top 73.6%.
Is Zentalis Pharmaceuticals' Piotroski F-Score too high?
Zentalis Pharmaceuticals' current Piotroski F-Score of 2 is near median its 10-year median of 2.00. Over the past 10 years, this metric has ranged from a low of 1.00 to a high of 6.00. The Biotechnology industry median Piotroski F-Score is 3.00. Zentalis Pharmaceuticals' value of 2 is 33.3% below this industry median. Based on the distribution chart, Zentalis Pharmaceuticals ranks #986 out of 1340 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Zentalis Pharmaceuticals has a GF Score™ of 32/100, reflecting its overall financial health beyond just this single metric.
How does Zentalis Pharmaceuticals' Piotroski F-Score compare to PROK and LYEL?
According to the Biotechnology industry distribution chart, Zentalis Pharmaceuticals ranks #986 out of 1340 companies for Piotroski F-Score. This places Zentalis Pharmaceuticals in the lower half of its industry. The industry median Piotroski F-Score is 3.00. Zentalis Pharmaceuticals' value of 2 is 33.3% below this benchmark. Historically, Zentalis Pharmaceuticals' own Piotroski F-Score has ranged from 1.00 to 6.00 over the past decade. While the company's 10-year median is 2.00 vs. the industry median of 3.00, Zentalis Pharmaceuticals has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Piotroski F-Score for a Biotechnology company?
The median Piotroski F-Score among Biotechnology companies is 3.00, based on 1,340 companies in the industry. Companies in the top quartile (top 25%) have a Piotroski F-Score significantly above this median, while those in the bottom quartile fall well below. However, Piotroski F-Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Zentalis Pharmaceuticals's current Piotroski F-Score of 2 is 33.3% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Piotroski F-Score mean?
A high Piotroski F-Score can signal that a stock is expensive relative to its fundamentals. The Piotroski F-score grades a company's business operating strength from 0-9. View historical data on Zentalis Pharmaceuticals and its competitors. For the Biotechnology industry, the median Piotroski F-Score is 3.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Zentalis Pharmaceuticals's current Piotroski F-Score is 2, which is near median its own 10-year median of 2.00. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Zentalis Pharmaceuticals stock overvalued right now?
Zentalis Pharmaceuticals (ZNTL) has a current Piotroski F-Score of 2. The current Piotroski F-Score is 2, which is near median its 10-year median of 2.00 and 33.3% below the Biotechnology industry median of 3.00. Zentalis Pharmaceuticals' overall GF Score™ is 32/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Piotroski F-Score calculated?
Piotroski F-Score is calculated from a company's financial statements. For Zentalis Pharmaceuticals (ZNTL), the current Piotroski F-Score is 2 as of Aug. 23, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Zentalis Pharmaceuticals Inc is a clinical-stage biopharmaceutical company developing azenosertib (ZN-c3), a potentially first-in-class and best-in-class WEE1 inhibitor for patients with Cyclin E1-positive platinum-resistant ovarian cancer (Cyclin E1+ PROC). The Company manages its operations as a single segment for the purposes of assessing performance and making operating decisions.
32GF Score
Get the complete analysis for ZNTL
Piotroski F-Score is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
ZNTL has been successfully added to your 
