DNLI (Denali Therapeutics) Gross Profit: $3.51 Mil (TTM As of Jun. 2026)

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DNLI Denali Therapeutics Inc DNLI
33 GF Score
Price $25.69
! 6 Warning Signs
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What is Denali Therapeutics Gross Profit?

Denali Therapeutics DNLI +5.63% 33 Gross Profit is $3.51 Mil as of Jun. 2026. GuruFocus rates DNLI with a GF Score™ of 33/100. The stock has 6 warning signs investors should review.

Denali Therapeutics's gross profit for the three months ended in Jun. 2026 was $3.51 Mil. Denali Therapeutics's gross profit for the trailing twelve months (TTM) ended in Jun. 2026 was $3.51 Mil.

Gross Margin % is calculated as gross profit divided by its revenue. Denali Therapeutics's gross profit for the three months ended in Jun. 2026 was $3.51 Mil. Denali Therapeutics's Revenue for the three months ended in Jun. 2026 was $3.60 Mil. Therefore, Denali Therapeutics's Gross Margin % for the quarter that ended in Jun. 2026 was 97.42%.

Denali Therapeutics had a gross margin of 97.42% for the quarter that ended in Jun. 2026 => Durable competitive advantage

During the past 11 years, the highest Gross Margin % of Denali Therapeutics was 97.42%. The lowest was 0.00%. And the median was 0.00%.


Denali Therapeutics  (NAS:DNLI) Gross Profit Explanation

Warren Buffett believes that firms with excellent long term economics tend to have consistently higher margins.

Durable competitive advantage creates a high Gross Margin % because of the freedom to price in excess of cost. Companies can be categorized by their Gross Margin %

1. Greater than 40% = Durable competitive advantage
2. Less than 40% = Competition eroding margins
3. Less than 20% = no sustainable competitive advantage
Consistency of Gross Margin is key

Denali Therapeutics had a gross margin of 97.42% for the quarter that ended in Jun. 2026 => Durable competitive advantage


Denali Therapeutics Gross Profit Related Terms


Denali Therapeutics Gross Profit Historical Data

* Premium members only.

The historical data trend for Denali Therapeutics's Gross Profit can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Denali Therapeutics Gross Profit Chart

Denali Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Gross Profit
Get a 7-Day Free Trial Premium Member Only Premium Member Only 48.66 108.46 330.53 0.00 0.00

Denali Therapeutics Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Gross Profit Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 3.51

DNLI vs RCUS, ALMS, ELVN: Gross Profit Comparison

For the Biotechnology subindustry, Denali Therapeutics's Gross Profit, along with its competitors' market caps and Gross Profit data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Denali Therapeutics Gross Profit vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Denali Therapeutics's Gross Profit distribution charts can be found below:

* The bar in red indicates where Denali Therapeutics's Gross Profit falls into.


DNLI
33GF Score
Denali Therapeutics Inc DNLI
Gross Profit is just one metric. See GF Score™, valuation, warning signs, and more.
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Denali Therapeutics Gross Profit Calculation

Gross Profit is the different between the sale prices and the cost of buying or producing the goods.

Denali Therapeutics's Gross Profit for the fiscal year that ended in Dec. 2025 is calculated as

Gross Profit (A: Dec. 2025 )=Revenue - Cost of Goods Sold
=0 - 0
=0.00

Denali Therapeutics's Gross Profit for the quarter that ended in Jun. 2026 is calculated as

Gross Profit (Q: Jun. 2026 )=Revenue - Cost of Goods Sold
=3.604 - 0.093
=3.51

Gross Profit for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $3.51 Mil.

Gross Profit is the numerator in the calculation of Gross Margin.

Denali Therapeutics's Gross Margin % for the quarter that ended in Jun. 2026 is calculated as

Gross Margin % (Q: Jun. 2026 )=Gross Profit (Q: Jun. 2026 ) / Revenue (Q: Jun. 2026 )
=(Revenue - Cost of Goods Sold) / Revenue
=3.51 / 3.604
=97.42 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

A positive Gross Profit is only the first step for a company to make a net profit. The gross profit needs to be big enough to also cover related labor, equipment, rental, marketing/advertising, research and development and a lot of other costs in selling the products.

Frequently Asked Questions Learn more about Gross Profit →
What does a Gross Profit of $3.51 Mil mean?
Denali Therapeutics (DNLI) has a Gross Profit of $3.51 Mil as of Jun. 2026. Gross Profit equals net sales less total cost of goods sold. View historical data on Denali Therapeutics and its competitors.
Is Denali Therapeutics' Gross Profit too high?
Denali Therapeutics' current Gross Profit is $3.51 Mil. Overall, Denali Therapeutics has a GF Score™ of 33/100, reflecting its overall financial health beyond just this single metric.
How does Denali Therapeutics' Gross Profit compare to RCUS and ALMS?
Denali Therapeutics' Gross Profit of $3.51 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Gross Profit for a Biotechnology company?
A good Gross Profit depends on the Biotechnology industry context. However, Gross Profit should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Gross Profit mean?
A high Gross Profit can signal that a stock is expensive relative to its fundamentals. Gross Profit equals net sales less total cost of goods sold. View historical data on Denali Therapeutics and its competitors. Denali Therapeutics's current Gross Profit is $3.51 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Denali Therapeutics stock overvalued right now?
Denali Therapeutics (DNLI) has a current Gross Profit of $3.51 Mil. The current Gross Profit is $3.51 Mil. Denali Therapeutics' overall GF Score™ is 33/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Gross Profit calculated?
Gross Profit is calculated from a company's financial statements. For Denali Therapeutics (DNLI), the current Gross Profit is $3.51 Mil as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Denali Therapeutics Business Description

Other Exchanges 4DN:GermanyD2NL34:Brazil
Address 161 Oyster Point Boulevard, South San Francisco, CA, USA, 94080
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
33GF Score

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Gross Profit is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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