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Denali TherapeuticsDNLI -1.45%33 10-Year Share Buyback Ratio is -7.30 as of Jun. 2026. GuruFocus rates DNLI with a GF Score™ of 33/100. The stock has 5 warning signs investors should review. Among 666 Biotechnology companies, Denali Therapeutics ranks better than 62.46% on this metric.
Shares Outstanding (EOP) are shares that have been authorized, issued, and purchased by investors and are held by them.
10-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past ten years. It is calculated as the annualized percentage change in shares outstanding from ten years ago to the current year. A positive ratio may indicate share buybacks over the period, while a zero or negative ratio may reflect no repurchases or potential share issuance. Denali Therapeutics's current 10-Year Share Buyback Ratio was -7.30%.
DNLI's 10-Year Share Buyback Ratio is ranked better than 62.46% of 666
companies
in the Biotechnology industry
Industry Median: -11.9
vs DNLI: -7.30
Denali Therapeutics (NAS:DNLI) 10-Year Share Buyback Ratio Explanation
A negative number means the company might be issuing new shares. A positive number indicates that the company is buying back shares.
Be Aware
Investors usually like share buybacks. But as pointed by Warren Buffett, only if a company buys back shares at the prices below the stock's intrinsic value, it rewards remaining shareholders. If a company buys its overvalued stocks back, it destroys shareholder value.
Denali Therapeutics 10-Year Share Buyback Ratio Related Terms
DNLI vs LEGN, IDYA, VKTX: 10-Year Share Buyback Ratio Comparison
For the Biotechnology subindustry, Denali Therapeutics's 10-Year Share Buyback Ratio, along with its competitors' market caps and 10-Year Share Buyback Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Denali Therapeutics 10-Year Share Buyback Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Denali Therapeutics's 10-Year Share Buyback Ratio distribution charts can be found below:
* The bar in red indicates where Denali Therapeutics's 10-Year Share Buyback Ratio falls into.
Denali Therapeutics 10-Year Share Buyback Ratio Calculation
This is the annualized percentage change in shares outstanding from ten years ago to the current year. The annualized percentage change is calculated with least-square regression based on the eleven years of annual data on Shares Outstanding (EOP).
Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average dividends per share growth rate.
What does a 10-Year Share Buyback Ratio of -7.30 mean?
Denali Therapeutics (DNLI) has a 10-Year Share Buyback Ratio of -7.30 as of Jun. 2026. The 10-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past ten years. It is calculated as the annualized percentage change in shares outstanding from ten years ago to the current year. View historical data for Denali Therapeutics and its competitors. According to the industry distribution chart, Denali Therapeutics ranks #250 out of 666 companies in the Biotechnology industry, placing it in the top 37.5%.
Is Denali Therapeutics' 10-Year Share Buyback Ratio too high?
Denali Therapeutics' current 10-Year Share Buyback Ratio is -7.30. Based on the distribution chart, Denali Therapeutics ranks #250 out of 666 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Denali Therapeutics has a GF Score™ of 33/100, reflecting its overall financial health beyond just this single metric.
How does Denali Therapeutics' 10-Year Share Buyback Ratio compare to LEGN and IDYA?
According to the Biotechnology industry distribution chart, Denali Therapeutics ranks #250 out of 666 companies for 10-Year Share Buyback Ratio. This puts Denali Therapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 10-Year Share Buyback Ratio for a Biotechnology company?
A good 10-Year Share Buyback Ratio depends on the Biotechnology industry context. However, 10-Year Share Buyback Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 10-Year Share Buyback Ratio mean?
A high 10-Year Share Buyback Ratio can signal that a stock is expensive relative to its fundamentals. The 10-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past ten years. It is calculated as the annualized percentage change in shares outstanding from ten years ago to the current year. View historical data for Denali Therapeutics and its competitors. Denali Therapeutics's current 10-Year Share Buyback Ratio is -7.30. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Denali Therapeutics stock overvalued right now?
Denali Therapeutics (DNLI) has a current 10-Year Share Buyback Ratio of -7.30. The current 10-Year Share Buyback Ratio is -7.30. Denali Therapeutics' overall GF Score™ is 33/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 10-Year Share Buyback Ratio calculated?
10-Year Share Buyback Ratio is calculated from a company's financial statements. For Denali Therapeutics (DNLI), the current 10-Year Share Buyback Ratio is -7.30 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
33GF Score
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