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Denali TherapeuticsDNLI +5.63%33 PB Ratio is 4.91 as of Aug. 20, 2026, which is 37% above its 10-year median of 3.58. GuruFocus rates DNLI with a GF Score™ of 33/100. The stock has 6 warning signs investors should review. Among 1,214 Biotechnology companies, Denali Therapeutics ranks worse than 67.55% on this metric.
Denali Therapeutics Inc stock PB Ratio (=4.65) is close to 3-year high of 4.94.
The historical rank and industry rank for Denali Therapeutics's PB Ratio or its related term are showing as below:
DNLI'
s PB Ratio Range Over the Past 10 Years
Min: 1.22 Med: 3.58 Max: 11.66
Current: 4.91
During the past 11 years, Denali Therapeutics's highest PB Ratio was 11.66. The lowest was 1.22. And the median was 3.58.
DNLI's PB Ratio is ranked worse than 67.55% of 1214
companies
in the Biotechnology industry
Industry Median: 2.94
vs DNLI: 4.91
During the past 12 months, Denali Therapeutics's average Book Value Per Share Growth Rate was -25.80% per year.
During the past 3 years, the average Book Value Per Share Growth Rate was -5.40% per year.
During the past 5 years, the average Book Value Per Share Growth Rate was -4.80% per year.
During the past 11 years, the highest 3-Year average Book Value Per Share Growth Rate of Denali Therapeutics was 23.20% per year. The lowest was -7.90% per year. And the median was 6.80% per year.
The PB Ratio works the best for the businesses that earn most of their profit from their assets, e.g. banks and insurance companies.
Be Aware
Some businesses have very light assets, such as software companies or insurance agencies. The PB Ratio does not work well for these companies. Some companies even have negative equity, so the PB Ratio cannot be applied to them.
Denali Therapeutics PB Ratio Related Terms
Denali Therapeutics PB Ratio Historical Data
* Premium members only.
The historical data trend for Denali Therapeutics's PB Ratio can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Denali Therapeutics's PB Ratio, along with its competitors' market caps and PB Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Denali Therapeutics PB Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Denali Therapeutics's PB Ratio distribution charts can be found below:
* The bar in red indicates where Denali Therapeutics's PB Ratio falls into.
The PB Ratio, or Price-to-Book ratio, or Price/Book, is a financial ratio used to compare a company's market price to its Book Value per Share. It is a ratio widely used to value stocks.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
It can also be calculated from the numbers for the whole company:
A closely related ratio is called Price-to-Tangible-Book. The difference between Price-to-Tangible-Book and PB Ratio is that book value other than intangibles are used in the calculation.
Denali Therapeutics (DNLI) has a PB Ratio of 4.91 as of Aug. 20, 2026. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on Denali Therapeutics and its competitors. This is 37% above median its historical median of 3.58. Over the past decade, Denali Therapeutics' PB Ratio has ranged from 1.22 to 11.66. According to the industry distribution chart, Denali Therapeutics ranks #820 out of 1214 companies in the Biotechnology industry, placing it in the top 67.5%.
Is Denali Therapeutics' PB Ratio too high?
Denali Therapeutics' current PB Ratio of 4.91 is 37% above median its 10-year median of 3.58. Over the past 10 years, this metric has ranged from a low of 1.22 to a high of 11.66. The Biotechnology industry median PB Ratio is 2.94. Denali Therapeutics' value of 4.91 is 67% above this industry median. Based on the distribution chart, Denali Therapeutics ranks #820 out of 1214 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Denali Therapeutics has a GF Score™ of 33/100, reflecting its overall financial health beyond just this single metric.
How does Denali Therapeutics' PB Ratio compare to RCUS and ALMS?
According to the Biotechnology industry distribution chart, Denali Therapeutics ranks #820 out of 1214 companies for PB Ratio. This places Denali Therapeutics in the lower half of its industry. The industry median PB Ratio is 2.94. Denali Therapeutics' value of 4.91 is 67% above this benchmark. Historically, Denali Therapeutics' own PB Ratio has ranged from 1.22 to 11.66 over the past decade. While the company's 10-year median is 3.58 vs. the industry median of 2.94, Denali Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good PB Ratio for a Biotechnology company?
The median PB Ratio among Biotechnology companies is 2.94, based on 1,214 companies in the industry. Companies in the top quartile (top 25%) have a PB Ratio significantly above this median, while those in the bottom quartile fall well below. However, PB Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Denali Therapeutics's current PB Ratio of 4.91 is 67% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high PB Ratio mean?
A high PB Ratio can signal that a stock is expensive relative to its fundamentals. Price-to-Book ratio is the ratio of share price to a company's book value per share. View historical data on Denali Therapeutics and its competitors. For the Biotechnology industry, the median PB Ratio is 2.94 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Denali Therapeutics's current PB Ratio is 4.91, which is 37% above median its own 10-year median of 3.58. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Denali Therapeutics stock overvalued right now?
Denali Therapeutics (DNLI) has a current PB Ratio of 4.91. The current PB Ratio is 4.91, which is 37% above median its 10-year median of 3.58 and 67% above the Biotechnology industry median of 2.94. Denali Therapeutics' overall GF Score™ is 33/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is PB Ratio calculated?
PB Ratio is calculated from a company's financial statements. For Denali Therapeutics (DNLI), the current PB Ratio is 4.91 as of Aug. 20, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegenerative diseases. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others. The Company has one operating segment with the goal to discover, develop, and commercializing therapeutics.
33GF Score
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