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Lyra TherapeuticsLYRA 29 Net Debt Paydown Yield % is 456.12% as of Jul. 31, 2026, which is 506700% above its 10-year median of 0.09. GuruFocus rates LYRA with a GF Score™ of 29/100 and a GF Value™ of $2.51 (Possible Value Trap). The stock has 4 warning signs investors should review. Among 1,161 Biotechnology companies, Lyra Therapeutics ranks better than 99.57% on this metric.
Net Debt Paydown Yield % is a metric that evaluates the total amount of debt a company has paid in relation to its market capitalization. It is a measure of a company's willingness and ability to reduce its debt.
As of today, Lyra Therapeutics's Net Debt Paydown Yield % was 456.12%.
Lyra Therapeutics (OTCPK:LYRA) Net Debt Paydown Yield % Explanation
Net Debt Paydown Yield % is the change in average of four quarters of company's total debt over a company's market cap. Assuming the total value of a company remains that same, shareholder value is increased as debt is reduced. In other words, it is a measure of the willingness and ability of a firm's management to pay down debt. Companies that have high debt paydown yields indicate that they are more aggressive with paying down debt.
In the calculation of Net Debt Paydown Yield %, we use the reductions of TTM average total debt one-year-ago and TTM average total debt at present, divided by its Market Cap.
Lyra Therapeutics Net Debt Paydown Yield % Related Terms
Lyra Therapeutics Net Debt Paydown Yield % Historical Data
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The historical data trend for Lyra Therapeutics's Net Debt Paydown Yield % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
LYRA vs ATXI, ZVSA, VBIO: Net Debt Paydown Yield % Comparison
For the Biotechnology subindustry, Lyra Therapeutics's Net Debt Paydown Yield %, along with its competitors' market caps and Net Debt Paydown Yield % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Lyra Therapeutics Net Debt Paydown Yield % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Lyra Therapeutics's Net Debt Paydown Yield % distribution charts can be found below:
* The bar in red indicates where Lyra Therapeutics's Net Debt Paydown Yield % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
* All the data are calculated by TTM values. Note that if a companies is traded in several exchanges, then we calculate the company level data for Net Debt Paydown Yield % using the primary share class stock data. The calculation result in definition page is for demonstration purpose only, and it's showing the share class level data. Therefore, the numbers in the calculation may differ from elsewhere if the stock is not a primary share.
What does a Net Debt Paydown Yield % of 456.12% mean?
Lyra Therapeutics (LYRA) has a Net Debt Paydown Yield % of 456.12% as of Jul. 31, 2026. Net Debt Paydown Yield is a metric that evaluates the total amount of debt a company has paid in relation to its market capitalization. This metric provides insight into a company's willingness and ability to reduce its debt using free cash flow. View historical data on Lyra Therapeutics and its competitors. This is 506700% above median its historical median of 0.09. According to the industry distribution chart, Lyra Therapeutics ranks #5 out of 1161 companies in the Biotechnology industry, placing it in the top 0.40000000000001%.
Is Lyra Therapeutics' Net Debt Paydown Yield % too high?
Lyra Therapeutics' current Net Debt Paydown Yield % of 456.12% is 506700% above median its 10-year median of 0.09. The Biotechnology industry median Net Debt Paydown Yield % is 0.04. Lyra Therapeutics' value of 456.12% is 1140200% above this industry median. Based on the distribution chart, Lyra Therapeutics ranks #5 out of 1161 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Lyra Therapeutics has a GF Score™ of 29/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Lyra Therapeutics' Net Debt Paydown Yield % compare to ATXI and ZVSA?
According to the Biotechnology industry distribution chart, Lyra Therapeutics ranks #5 out of 1161 companies for Net Debt Paydown Yield %. This places Lyra Therapeutics in the top 0% of its industry — outperforming the majority of peers. The industry median Net Debt Paydown Yield % is 0.04. Lyra Therapeutics' value of 456.12% is 1140200% above this benchmark. While the company's 10-year median is 0.09 vs. the industry median of 0.04, Lyra Therapeutics has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Net Debt Paydown Yield % for a Biotechnology company?
The median Net Debt Paydown Yield % among Biotechnology companies is 0.04, based on 1,161 companies in the industry. Companies in the top quartile (top 25%) have a Net Debt Paydown Yield % significantly above this median, while those in the bottom quartile fall well below. However, Net Debt Paydown Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Lyra Therapeutics's current Net Debt Paydown Yield % of 456.12% is 1140200% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Net Debt Paydown Yield % mean?
A high Net Debt Paydown Yield % can signal that a stock is expensive relative to its fundamentals. Net Debt Paydown Yield is a metric that evaluates the total amount of debt a company has paid in relation to its market capitalization. This metric provides insight into a company's willingness and ability to reduce its debt using free cash flow. View historical data on Lyra Therapeutics and its competitors. For the Biotechnology industry, the median Net Debt Paydown Yield % is 0.04 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Lyra Therapeutics's current Net Debt Paydown Yield % is 456.12%, which is 506700% above median its own 10-year median of 0.09. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lyra Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Lyra Therapeutics (LYRA) is currently considered Possible Value Trap. The stock's GF Value™ is $2.51, compared to a current price of $0.48 — trading 81.1% below its estimated fair value. The current Net Debt Paydown Yield % is 456.12%, which is 506700% above median its 10-year median of 0.09 and 1140200% above the Biotechnology industry median of 0.04. Lyra Therapeutics' overall GF Score™ is 29/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Net Debt Paydown Yield % calculated?
Net Debt Paydown Yield % is calculated from a company's financial statements. For Lyra Therapeutics (LYRA), the current Net Debt Paydown Yield % is 456.12% as of Jul. 31, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Lyra Therapeutics (LYRA) Overvalued in 2026?
Based on GuruFocus' analysis, Lyra Therapeutics stock appears to be undervalued.
The current stock price of $0.48 is trading 81.1% below its estimated GF Value™ of $2.51.
GuruFocus considers Lyra Therapeutics to be Possible Value Trap.
Key valuation signals for LYRA:
Net Debt Paydown Yield %: 456.12% (506700% above median its 10-year median of 0.09)
GF Value™: $2.51 vs. price of $0.48 (81.1% below fair value)
Industry Position: 1140200% above the Biotechnology median (#5 of 1161)
No single metric tells the full story. See the LYRA stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Lyra Therapeutics Inc is a clinical-stage biotechnology company focused on the development and commercialization of anti-inflammatory therapies for the localized treatment of patients with chronic rhinosinusitis, or CRS. Its products include LYR-210 and LYR-220. The company operates in a single operating segment, which is the business of developing targeted medicines to address ear, nose, and throat, or ENT, diseases.
29GF Score
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