LYRA (Lyra Therapeutics) Research & Development: $18.41 Mil (TTM As of Dec. 2025)


LYRA Lyra Therapeutics Inc LYRA
29 GF Score
Price $0.60
GF Value $2.55
Valuation Possible Value Trap
! 4 Warning Signs
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What is Lyra Therapeutics Research & Development?

Lyra Therapeutics LYRA +2.92% 29 Research & Development is $18.41 Mil as of Dec. 2025. GuruFocus rates LYRA with a GF Score™ of 29/100 and a GF Value™ of $2.55 (Possible Value Trap). The stock has 4 warning signs investors should review.

Research & Development is the aggregate amount of research and development expenses during the year. Lyra Therapeutics's Research & Development for the three months ended in Dec. 2025 was $4.38 Mil. Its Research & Development for the trailing twelve months (TTM) ended in Dec. 2025 was $18.41 Mil.

Lyra Therapeutics  (OTCPK:LYRA) Research & Development Explanation

If competitive advantage is created by a patent or tech advantage, at some point it will disappear.

High R&D usually dictates high SG&A which threatens the competitive advantage.

Lyra Therapeutics Research & Development Related Terms

Lyra Therapeutics Research & Development Historical Data

* Premium members only.

The historical data trend for Lyra Therapeutics's Research & Development can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lyra Therapeutics Research & Development Chart

Lyra Therapeutics Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Research & Development
Get a 7-Day Free Trial 29.69 38.80 48.03 43.77 18.41

Lyra Therapeutics Quarterly Data
Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25
Research & Development Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 6.36 4.88 5.11 4.05 4.38
LYRA
29GF Score
Lyra Therapeutics Inc LYRA
Research & Development is just one metric. See GF Score™, valuation, warning signs, and more.
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Lyra Therapeutics Research & Development Calculation

This is the expense the company spent on research and development.

Research & Development for the trailing twelve months (TTM) ended in Dec. 2025 adds up the quarterly data reported by the company within the most recent 12 months, which was $18.41 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Research & Development →
What does a Research & Development of $18.41 Mil mean?
Lyra Therapeutics (LYRA) has a Research & Development of $18.41 Mil as of Dec. 2025. Research and development expense is the total cost for research and development activities. View historical data on Lyra Therapeutics and its competitors.
Is Lyra Therapeutics' Research & Development too high?
Lyra Therapeutics' current Research & Development is $18.41 Mil. Overall, Lyra Therapeutics has a GF Score™ of 29/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Lyra Therapeutics' Research & Development compare to ISCO and ONCO?
Lyra Therapeutics' Research & Development of $18.41 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Research & Development for a Biotechnology company?
A good Research & Development depends on the Biotechnology industry context. However, Research & Development should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Research & Development mean?
A high Research & Development can signal that a stock is expensive relative to its fundamentals. Research and development expense is the total cost for research and development activities. View historical data on Lyra Therapeutics and its competitors. Lyra Therapeutics's current Research & Development is $18.41 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lyra Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Lyra Therapeutics (LYRA) is currently considered Possible Value Trap. The stock's GF Value™ is $2.55, compared to a current price of $0.60 — trading 76.5% below its estimated fair value. The current Research & Development is $18.41 Mil. Lyra Therapeutics' overall GF Score™ is 29/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Research & Development calculated?
Research & Development is calculated from a company's financial statements. For Lyra Therapeutics (LYRA), the current Research & Development is $18.41 Mil as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Lyra Therapeutics (LYRA) Overvalued in 2026?

Based on GuruFocus' analysis, Lyra Therapeutics stock appears to be undervalued. The current stock price of $0.60 is trading 76.5% below its estimated GF Value™ of $2.55. GuruFocus considers Lyra Therapeutics to be Possible Value Trap.

Key valuation signals for LYRA:

  • Research & Development: $18.41 Mil
  • GF Value™: $2.55 vs. price of $0.60 (76.5% below fair value)
  • GF Score™: 29/100 with 4 warning signs

No single metric tells the full story. See the LYRA stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.

Lyra Therapeutics Business Description

Address 480 Arsenal Way, Watertown, MA, USA, 02472
Lyra Therapeutics Inc is a clinical-stage biotechnology company focused on the development and commercialization of anti-inflammatory therapies for the localized treatment of patients with chronic rhinosinusitis, or CRS. Its products include LYR-210 and LYR-220. The company operates in a single operating segment, which is the business of developing targeted medicines to address ear, nose, and throat, or ENT, diseases.
29GF Score

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Research & Development is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$0.60
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$2.55
GF Value