The historical rank and industry rank for International Stem Cell's Net Margin % or its related term are showing as below:
ISCO'
s Net Margin % Range Over the Past 10 Years
Min: -81.4 Med: -13.8 Max: -1.68
Current: -4.11
ISCO's Net Margin % is ranked better than 68.64% of 947
companies
in the Biotechnology industry
Industry Median: -89.56
vs ISCO: -4.11
International Stem Cell (OTCPK:ISCO) Net Margin % Explanation
Although Net Income and Earnings-per-Share (EPS) are the most widely used parameter in measuring a company's profitability and valuation, it is the least reliable. The reason is that reported earnings can be manipulated easily by adjusting any numbers such as Depreciation, Depletion and Amotorization and non-recurring items.
But the long term trend of the net margin is a good indicator of the competitiveness and health of the business.
International Stem Cell Net Margin % Related Terms
International Stem Cell Net Margin % Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, International Stem Cell's Net Margin %, along with its competitors' market caps and Net Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
International Stem Cell Net Margin % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, International Stem Cell's Net Margin % distribution charts can be found below:
* The bar in red indicates where International Stem Cell's Net Margin % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
International Stem Cell (ISCO) has a Net Margin % of -9.50% as of Mar. 2026. Net margin is the ratio of total net income to net sales. View historical data on International Stem Cell and its competitors. According to the industry distribution chart, International Stem Cell ranks #297 out of 947 companies in the Biotechnology industry, placing it in the top 31.4%.
Is International Stem Cell's Net Margin % too high?
International Stem Cell's current Net Margin % is -9.50%. Based on the distribution chart, International Stem Cell ranks #297 out of 947 companies in the Biotechnology industry, which is above the industry midpoint. Overall, International Stem Cell has a GF Score™ of 28/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does International Stem Cell's Net Margin % compare to ONCO and VRAX?
According to the Biotechnology industry distribution chart, International Stem Cell ranks #297 out of 947 companies for Net Margin %. This puts International Stem Cell in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Net Margin % for a Biotechnology company?
A good Net Margin % depends on the Biotechnology industry context. However, Net Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Net Margin % mean?
A high Net Margin % can signal that a stock is expensive relative to its fundamentals. Net margin is the ratio of total net income to net sales. View historical data on International Stem Cell and its competitors. International Stem Cell's current Net Margin % is -9.50%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is International Stem Cell stock overvalued right now?
Based on GuruFocus' analysis, International Stem Cell (ISCO) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.13, compared to a current price of $0.18 — trading 37% above its estimated fair value. The current Net Margin % is -9.50%. International Stem Cell's overall GF Score™ is 28/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Net Margin % calculated?
Net Margin % is calculated from a company's financial statements. For International Stem Cell (ISCO), the current Net Margin % is -9.50% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is International Stem Cell (ISCO) Overvalued in 2026?
Based on GuruFocus' analysis, International Stem Cell stock appears to be overvalued.
The current stock price of $0.18 is trading 37% above its estimated GF Value™ of $0.13.
GuruFocus considers International Stem Cell to be Significantly Overvalued.
Key valuation signals for ISCO:
Net Margin %: -9.50%
GF Value™: $0.13 vs. price of $0.18 (37% above fair value)
No single metric tells the full story. See the ISCO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
International Stem Cell Corp is a clinical-stage biotechnology company. It is focused on therapeutic and biomedical product development with multiple long-term therapeutic opportunities. The company develops different cell types from its stem cells that may result in therapeutic products. The clinical applications of the company include neural stem cells for the treatment of Parkinson's disease and other central nervous system disorders; Liver cells, which are used to treat a variety of congenital and acquired liver diseases; and retinal cells and three-dimensional eye structures. The company operates in three segments, the therapeutic market, the biomedical market, and the anti-aging market. The Biomedical products business segment accounts for the majority of revenue.
28GF Score
Get the complete analysis for ISCO
Net Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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