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3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
International Stem Cell's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was 14.33%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for International Stem Cell's 3-Year ROIIC % or its related term are showing as below:
ISCO's 3-Year ROIIC % is ranked better than 63.16% of 1322
companies
in the Biotechnology industry
Industry Median: -4.9
vs ISCO: 14.33
International Stem Cell (OTCPK:ISCO) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
International Stem Cell 3-Year ROIIC % Related Terms
International Stem Cell 3-Year ROIIC % Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ISCO vs ZVSA, AXIM, HEPA: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, International Stem Cell's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
International Stem Cell 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, International Stem Cell's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where International Stem Cell's 3-Year ROIIC % falls into.
International Stem Cell 3-Year ROIIC % Calculation
International Stem Cell's 3-Year ROIIC % for the quarter that ended in Dec. 2025 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -0.267 (Dec. 2025) - -0.183 (Dec. 2022) )
/
( 5.391 (Dec. 2025) - 5.977 (Dec. 2022) )
=
-0.084
/
-0.586
=
14.33%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
International Stem Cell (ISCO) has a 3-Year ROIIC % of 14.33 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on International Stem Cell and its competitors. According to the industry distribution chart, International Stem Cell ranks #487 out of 1322 companies in the Biotechnology industry, placing it in the top 36.8%.
Is International Stem Cell's 3-Year ROIIC % too high?
International Stem Cell's current 3-Year ROIIC % is 14.33. Based on the distribution chart, International Stem Cell ranks #487 out of 1322 companies in the Biotechnology industry, which is above the industry midpoint. Overall, International Stem Cell has a GF Score™ of 28/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does International Stem Cell's 3-Year ROIIC % compare to ZVSA and AXIM?
According to the Biotechnology industry distribution chart, International Stem Cell ranks #487 out of 1322 companies for 3-Year ROIIC %. This puts International Stem Cell in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on International Stem Cell and its competitors. International Stem Cell's current 3-Year ROIIC % is 14.33. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is International Stem Cell stock overvalued right now?
Based on GuruFocus' analysis, International Stem Cell (ISCO) is currently considered Significantly Overvalued. The stock's GF Value™ is $0.13, compared to a current price of $0.28 — trading 115.4% above its estimated fair value. The current 3-Year ROIIC % is 14.33. International Stem Cell's overall GF Score™ is 28/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For International Stem Cell (ISCO), the current 3-Year ROIIC % is 14.33 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is International Stem Cell (ISCO) Overvalued in 2026?
Based on GuruFocus' analysis, International Stem Cell stock appears to be overvalued.
The current stock price of $0.28 is trading 115.4% above its estimated GF Value™ of $0.13.
GuruFocus considers International Stem Cell to be Significantly Overvalued.
Key valuation signals for ISCO:
3-Year ROIIC %: 14.33
GF Value™: $0.13 vs. price of $0.28 (115.4% above fair value)
No single metric tells the full story. See the ISCO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
International Stem Cell Corp is a clinical-stage biotechnology company. It is focused on therapeutic and biomedical product development with multiple long-term therapeutic opportunities. The company develops different cell types from its stem cells that may result in therapeutic products. The clinical applications of the company include neural stem cells for the treatment of Parkinson's disease and other central nervous system disorders; Liver cells, which are used to treat a variety of congenital and acquired liver diseases; and retinal cells and three-dimensional eye structures. The company operates in three segments, the therapeutic market, the biomedical market, and the anti-aging market. The Biomedical products business segment accounts for the majority of revenue.
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