XBIO (Xenetic Biosciences) Net Margin %: -56.51% (As of Mar. 2026)


XBIO Xenetic Biosciences Inc XBIO
83 GF Score
Price $2.95
GF Value $4.18
Valuation Possible Value Trap
! 2 Warning Signs
View Full Analysis

What is Xenetic Biosciences Net Margin %?

Xenetic Biosciences XBIO -0.84% 83 Net Margin % is -56.51% as of Mar. 2026. GuruFocus rates XBIO with a GF Score™ of 83/100 and a GF Value™ of $4.18 (Possible Value Trap). The stock has 2 warning signs investors should review. Among 946 Biotechnology companies, Xenetic Biosciences ranks better than 52.01% on this metric.

Net margin is calculated as Net Income divided by its Revenue. Xenetic Biosciences's Net Income for the three months ended in Mar. 2026 was $-0.46 Mil. Xenetic Biosciences's Revenue for the three months ended in Mar. 2026 was $0.81 Mil. Therefore, Xenetic Biosciences's net margin for the quarter that ended in Mar. 2026 was -56.51%.

The historical rank and industry rank for Xenetic Biosciences's Net Margin % or its related term are showing as below:

XBIO' s Net Margin % Range Over the Past 10 Years
Min: -75147.06   Med: -383.83   Max: -47.4
Current: -70.03


XBIO's Net Margin % is ranked better than
52.01% of 946 companies
in the Biotechnology industry
Industry Median: -88.815 vs XBIO: -70.03

Xenetic Biosciences  (NAS:XBIO) Net Margin % Explanation

Although Net Income and Earnings-per-Share (EPS) are the most widely used parameter in measuring a company's profitability and valuation, it is the least reliable. The reason is that reported earnings can be manipulated easily by adjusting any numbers such as Depreciation, Depletion and Amotorization and non-recurring items.

But the long term trend of the net margin is a good indicator of the competitiveness and health of the business.


Xenetic Biosciences Net Margin % Related Terms


Xenetic Biosciences Net Margin % Historical Data

* Premium members only.

The historical data trend for Xenetic Biosciences's Net Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Xenetic Biosciences Net Margin % Chart

Xenetic Biosciences Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Net Margin %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -486.22 -383.83 -162.80 -158.40 -90.09

Xenetic Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Net Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -152.28 -116.78 -49.66 -75.59 -56.51

XBIO vs PCSA, SILO, LIMN: Net Margin % Comparison

For the Biotechnology subindustry, Xenetic Biosciences's Net Margin %, along with its competitors' market caps and Net Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Xenetic Biosciences Net Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Xenetic Biosciences's Net Margin % distribution charts can be found below:

* The bar in red indicates where Xenetic Biosciences's Net Margin % falls into.


XBIO
83GF Score
Xenetic Biosciences Inc XBIO
Net Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Xenetic Biosciences Net Margin % Calculation

Net margin - also known as net profit margin is the ratio of Net Income divided by net sales or Revenue, usually presented in percent.

Xenetic Biosciences's Net Margin for the fiscal year that ended in Dec. 2025 is calculated as

Net Margin=Net Income (A: Dec. 2025 )/Revenue (A: Dec. 2025 )
=-2.681/2.976
=-90.09 %

Xenetic Biosciences's Net Margin for the quarter that ended in Mar. 2026 is calculated as

Net Margin=Net Income (Q: Mar. 2026 )/Revenue (Q: Mar. 2026 )
=-0.456/0.807
=-56.51 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Net Margin % →
What does a Net Margin % of -56.51% mean?
Xenetic Biosciences (XBIO) has a Net Margin % of -56.51% as of Mar. 2026. Net margin is the ratio of total net income to net sales. View historical data on Xenetic Biosciences and its competitors. According to the industry distribution chart, Xenetic Biosciences ranks #454 out of 946 companies in the Biotechnology industry, placing it in the top 48%.
Is Xenetic Biosciences' Net Margin % too high?
Xenetic Biosciences' current Net Margin % is -56.51%. Based on the distribution chart, Xenetic Biosciences ranks #454 out of 946 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Xenetic Biosciences has a GF Score™ of 83/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Xenetic Biosciences' Net Margin % compare to PCSA and SILO?
According to the Biotechnology industry distribution chart, Xenetic Biosciences ranks #454 out of 946 companies for Net Margin %. This puts Xenetic Biosciences in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Net Margin % for a Biotechnology company?
A good Net Margin % depends on the Biotechnology industry context. However, Net Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Net Margin % mean?
A high Net Margin % can signal that a stock is expensive relative to its fundamentals. Net margin is the ratio of total net income to net sales. View historical data on Xenetic Biosciences and its competitors. Xenetic Biosciences's current Net Margin % is -56.51%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Xenetic Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Xenetic Biosciences (XBIO) is currently considered Possible Value Trap. The stock's GF Value™ is $4.18, compared to a current price of $2.95 — trading 29.5% below its estimated fair value. The current Net Margin % is -56.51%. Xenetic Biosciences' overall GF Score™ is 83/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Net Margin % calculated?
Net Margin % is calculated from a company's financial statements. For Xenetic Biosciences (XBIO), the current Net Margin % is -56.51% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Xenetic Biosciences (XBIO) Overvalued in 2026?

Based on GuruFocus' analysis, Xenetic Biosciences stock appears to be undervalued. The current stock price of $2.95 is trading 29.5% below its estimated GF Value™ of $4.18. GuruFocus considers Xenetic Biosciences to be Possible Value Trap.

Key valuation signals for XBIO:

  • Net Margin %: -56.51%
  • GF Value™: $4.18 vs. price of $2.95 (29.5% below fair value)
  • GF Score™: 83/100 with 2 warning signs

No single metric tells the full story. See the XBIO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Xenetic Biosciences Business Description

Address 945 Concord Street, Framingham, MA, USA, 01701
Xenetic Biosciences Inc is a biopharmaceutical company focused on progressing XCART, a personalized CAR T platform technology engineered to target patient-specific tumor neoantigens. The Company is initially advancing cell-based therapeutics targeting the unique B-cell receptor on the surface of an individual patient’s malignant tumor cells for the treatment of B-cell lymphomas. XCART has the potential to fuel a robust pipeline of therapeutic assets targeting high-value oncology indications. Additionally, Xenetic is leveraging PolyXen™, its proprietary drug delivery platform, by partnering with biotechnology and pharmaceutical companies. PolyXen™ has demonstrated its ability to improve the half-life and other pharmacological properties of next-generation biologic drugs. The Company has an exclusive license agreement with Takeda Pharmaceuticals Co. Ltd. in the field of coagulation disorders and expects to earn royalty payments under this agreement.
83GF Score

Get the complete analysis for XBIO

Net Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$2.95
Price
$4.18
GF Value