XBIO (Xenetic Biosciences) ROA %: -22.42% (As of Mar. 2026)


XBIO Xenetic Biosciences Inc XBIO
83 GF Score
Price $2.95
GF Value $4.18
Valuation Possible Value Trap
! 2 Warning Signs
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What is Xenetic Biosciences ROA %?

Xenetic Biosciences XBIO -0.84% 83 ROA % is -22.42% as of Mar. 2026. GuruFocus rates XBIO with a GF Score™ of 83/100 and a GF Value™ of $4.18 (Possible Value Trap). The stock has 2 warning signs investors should review. Among 1,419 Biotechnology companies, Xenetic Biosciences ranks worse than 51.66% on this metric.

ROA % is calculated as Net Income divided by its average Total Assets over a certain period of time. Xenetic Biosciences's annualized Net Income for the quarter that ended in Mar. 2026 was $-1.82 Mil. Xenetic Biosciences's average Total Assets over the quarter that ended in Mar. 2026 was $8.14 Mil. Therefore, Xenetic Biosciences's annualized ROA % for the quarter that ended in Mar. 2026 was -22.42%.

The historical rank and industry rank for Xenetic Biosciences's ROA % or its related term are showing as below:

XBIO' s ROA % Range Over the Past 10 Years
Min: -286.18   Med: -40.7   Max: -17.91
Current: -34.38

During the past 13 years, Xenetic Biosciences's highest ROA % was -17.91%. The lowest was -286.18%. And the median was -40.70%.

XBIO's ROA % is ranked worse than
51.66% of 1419 companies
in the Biotechnology industry
Industry Median: -32.84 vs XBIO: -34.38

Xenetic Biosciences  (NAS:XBIO) ROA % Explanation

ROA % measures the rate of return on the total assets (shareholder equity plus liabilities). It measures a firm's efficiency at generating profits from shareholders' equity plus its liabilities. ROA % shows how well a company uses what it has to generate earnings. ROA %s can vary drastically across industries. Therefore, ROA % should not be used to compare companies in different industries. For retailers, a ROA % of higher than 5% is expected. For example, Wal-Mart (WMT) has a ROA % of about 8% as of 2012. For banks, ROA % is close to their interest spread. A bank’s ROA % is typically well under 2%.

Similar to ROE, ROA % is affected by profit margins and asset turnover. This can be seen from the Du Pont Formula:

ROA %(Q: Mar. 2026 )
=Net Income/Total Assets
=-1.824/8.1365
=(Net Income / Revenue)*(Revenue / Total Assets)
=(-1.824 / 3.228)*(3.228 / 8.1365)
=Net Margin %*Asset Turnover
=-56.51 %*0.3967
=-22.42 %

Note: The Net Income data used here is four times the quarterly (Mar. 2026) net income data. The Revenue data used here is four times the quarterly (Mar. 2026) revenue data.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Be Aware

Like ROE, ROA % is calculated with only 12 months data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. ROA % can be affected by events such as stock buyback or issuance, and by goodwill, a company's tax rate and its interest payment. ROA % may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).

Many analysts argue the higher return the better. Buffett states that really high ROA % may indicate vulnerability in the durability of the competitive advantage.

E.g. Raising $43b to take on KO is impossible, but $1.7b to take on Moody's is. Although Moody's ROA % and underlying economics is far superior to Coca Cola, the durability is far weaker because of lower entry cost.


Xenetic Biosciences ROA % Related Terms


Xenetic Biosciences ROA % Historical Data

* Premium members only.

The historical data trend for Xenetic Biosciences's ROA % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Xenetic Biosciences ROA % Chart

Xenetic Biosciences Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROA %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -34.22 -37.94 -32.66 -45.24 -35.13

Xenetic Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROA % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -56.92 -49.46 -39.15 -34.48 -22.42

XBIO vs ACXP, SILO, GOVX: ROA % Comparison

For the Biotechnology subindustry, Xenetic Biosciences's ROA %, along with its competitors' market caps and ROA % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Xenetic Biosciences ROA % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Xenetic Biosciences's ROA % distribution charts can be found below:

* The bar in red indicates where Xenetic Biosciences's ROA % falls into.


XBIO
83GF Score
Xenetic Biosciences Inc XBIO
ROA % is just one metric. See GF Score™, valuation, warning signs, and more.
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Xenetic Biosciences ROA % Calculation

Xenetic Biosciences's annualized ROA % for the fiscal year that ended in Dec. 2025 is calculated as:

ROA %=Net Income (A: Dec. 2025 )/( (Total Assets (A: Dec. 2024 )+Total Assets (A: Dec. 2025 ))/ count )
=-2.681/( (6.901+8.364)/ 2 )
=-2.681/7.6325
=-35.13 %

Xenetic Biosciences's annualized ROA % for the quarter that ended in Mar. 2026 is calculated as:

ROA %=Net Income (Q: Mar. 2026 )/( (Total Assets (Q: Dec. 2025 )+Total Assets (Q: Mar. 2026 ))/ count )
=-1.824/( (8.364+7.909)/ 2 )
=-1.824/8.1365
=-22.42 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual ROA %, the net income of the last fiscal year and the average total assets over the fiscal year are used. In calculating the quarterly data, the Net Income data used here is four times the quarterly (Mar. 2026) net income data. ROA % is displayed in the 30-year financial page.

Frequently Asked Questions Learn more about ROA % →
What does a ROA % of -22.42% mean?
Xenetic Biosciences (XBIO) has a ROA % of -22.42% as of Mar. 2026. Return on assets is the ratio of current-period net income to average two-period total assets. View historical data on Xenetic Biosciences and its competitors. According to the industry distribution chart, Xenetic Biosciences ranks #733 out of 1419 companies in the Biotechnology industry, placing it in the top 51.7%.
Is Xenetic Biosciences' ROA % too high?
Xenetic Biosciences' current ROA % is -22.42%. Based on the distribution chart, Xenetic Biosciences ranks #733 out of 1419 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Xenetic Biosciences has a GF Score™ of 83/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Xenetic Biosciences' ROA % compare to ACXP and SILO?
According to the Biotechnology industry distribution chart, Xenetic Biosciences ranks #733 out of 1419 companies for ROA %. This places Xenetic Biosciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROA % for a Biotechnology company?
A good ROA % depends on the Biotechnology industry context. However, ROA % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROA % mean?
A high ROA % can signal that a stock is expensive relative to its fundamentals. Return on assets is the ratio of current-period net income to average two-period total assets. View historical data on Xenetic Biosciences and its competitors. Xenetic Biosciences's current ROA % is -22.42%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Xenetic Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Xenetic Biosciences (XBIO) is currently considered Possible Value Trap. The stock's GF Value™ is $4.18, compared to a current price of $2.95 — trading 29.5% below its estimated fair value. The current ROA % is -22.42%. Xenetic Biosciences' overall GF Score™ is 83/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROA % calculated?
ROA % is calculated from a company's financial statements. For Xenetic Biosciences (XBIO), the current ROA % is -22.42% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Xenetic Biosciences (XBIO) Overvalued in 2026?

Based on GuruFocus' analysis, Xenetic Biosciences stock appears to be undervalued. The current stock price of $2.95 is trading 29.5% below its estimated GF Value™ of $4.18. GuruFocus considers Xenetic Biosciences to be Possible Value Trap.

Key valuation signals for XBIO:

  • ROA %: -22.42%
  • GF Value™: $4.18 vs. price of $2.95 (29.5% below fair value)
  • GF Score™: 83/100 with 2 warning signs

No single metric tells the full story. See the XBIO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Xenetic Biosciences Business Description

Address 945 Concord Street, Framingham, MA, USA, 01701
Xenetic Biosciences Inc is a biopharmaceutical company focused on progressing XCART, a personalized CAR T platform technology engineered to target patient-specific tumor neoantigens. The Company is initially advancing cell-based therapeutics targeting the unique B-cell receptor on the surface of an individual patient’s malignant tumor cells for the treatment of B-cell lymphomas. XCART has the potential to fuel a robust pipeline of therapeutic assets targeting high-value oncology indications. Additionally, Xenetic is leveraging PolyXen™, its proprietary drug delivery platform, by partnering with biotechnology and pharmaceutical companies. PolyXen™ has demonstrated its ability to improve the half-life and other pharmacological properties of next-generation biologic drugs. The Company has an exclusive license agreement with Takeda Pharmaceuticals Co. Ltd. in the field of coagulation disorders and expects to earn royalty payments under this agreement.
83GF Score

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ROA % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$2.95
Price
$4.18
GF Value