XBIO (Xenetic Biosciences) ROE % Adjusted to Book Value: -28.90% (As of Mar. 2026)


XBIO Xenetic Biosciences Inc XBIO
79 GF Score
Price $2.89
GF Value $4.20
Valuation Possible Value Trap
! 2 Warning Signs
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What is Xenetic Biosciences ROE % Adjusted to Book Value?

Xenetic Biosciences XBIO +1.40% 79 ROE % Adjusted to Book Value is -28.90% as of Mar. 2026. GuruFocus rates XBIO with a GF Score™ of 79/100 and a GF Value™ of $4.20 (Possible Value Trap). The stock has 2 warning signs investors should review.

Xenetic Biosciences's ROE % for the quarter that ended in Mar. 2026 was -25.43%. Xenetic Biosciences's PB Ratio for the quarter that ended in Mar. 2026 was 0.88. Xenetic Biosciences's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was -28.90%.


Xenetic Biosciences ROE % Adjusted to Book Value Related Terms


Xenetic Biosciences ROE % Adjusted to Book Value Historical Data

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The historical data trend for Xenetic Biosciences's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Xenetic Biosciences ROE % Adjusted to Book Value Chart

Xenetic Biosciences Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
Get a 7-Day Free Trial Premium Member Only Premium Member Only -39.23 -127.81 -65.33 -49.14 -59.72

Xenetic Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -82.16 -42.34 -39.79 -60.90 -28.90

XBIO vs ACXP, SILO, GOVX: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Xenetic Biosciences's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Xenetic Biosciences ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Xenetic Biosciences's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Xenetic Biosciences's ROE % Adjusted to Book Value falls into.


XBIO
79GF Score
Xenetic Biosciences Inc XBIO
ROE % Adjusted to Book Value is just one metric. See GF Score™, valuation, warning signs, and more.
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Xenetic Biosciences ROE % Adjusted to Book Value Calculation

Xenetic Biosciences's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-40.01% / 0.67
=-59.72%

Xenetic Biosciences's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-25.43% / 0.88
=-28.90%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of -28.90% mean?
Xenetic Biosciences (XBIO) has a ROE % Adjusted to Book Value of -28.90% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Xenetic Biosciences and its competitors.
Is Xenetic Biosciences' ROE % Adjusted to Book Value too high?
Xenetic Biosciences' current ROE % Adjusted to Book Value is -28.90%. Overall, Xenetic Biosciences has a GF Score™ of 79/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Xenetic Biosciences' ROE % Adjusted to Book Value compare to ACXP and SILO?
Xenetic Biosciences' ROE % Adjusted to Book Value of -28.90% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Xenetic Biosciences and its competitors. Xenetic Biosciences's current ROE % Adjusted to Book Value is -28.90%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Xenetic Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Xenetic Biosciences (XBIO) is currently considered Possible Value Trap. The stock's GF Value™ is $4.20, compared to a current price of $2.89 — trading 31.2% below its estimated fair value. The current ROE % Adjusted to Book Value is -28.90%. Xenetic Biosciences' overall GF Score™ is 79/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Xenetic Biosciences (XBIO), the current ROE % Adjusted to Book Value is -28.90% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Xenetic Biosciences (XBIO) Overvalued in 2026?

Based on GuruFocus' analysis, Xenetic Biosciences stock appears to be undervalued. The current stock price of $2.89 is trading 31.2% below its estimated GF Value™ of $4.20. GuruFocus considers Xenetic Biosciences to be Possible Value Trap.

Key valuation signals for XBIO:

  • ROE % Adjusted to Book Value: -28.90%
  • GF Value™: $4.20 vs. price of $2.89 (31.2% below fair value)
  • GF Score™: 79/100 with 2 warning signs

No single metric tells the full story. See the XBIO stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Xenetic Biosciences Business Description

Address 945 Concord Street, Framingham, MA, USA, 01701
Xenetic Biosciences Inc is a biopharmaceutical company focused on progressing XCART, a personalized CAR T platform technology engineered to target patient-specific tumor neoantigens. The Company is initially advancing cell-based therapeutics targeting the unique B-cell receptor on the surface of an individual patient’s malignant tumor cells for the treatment of B-cell lymphomas. XCART has the potential to fuel a robust pipeline of therapeutic assets targeting high-value oncology indications. Additionally, Xenetic is leveraging PolyXen™, its proprietary drug delivery platform, by partnering with biotechnology and pharmaceutical companies. PolyXen™ has demonstrated its ability to improve the half-life and other pharmacological properties of next-generation biologic drugs. The Company has an exclusive license agreement with Takeda Pharmaceuticals Co. Ltd. in the field of coagulation disorders and expects to earn royalty payments under this agreement.
79GF Score

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ROE % Adjusted to Book Value is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$2.89
Price
$4.20
GF Value