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Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Caribou Biosciences's annualized net income for the quarter that ended in Mar. 2026 was $-100.34 Mil. Caribou Biosciences's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $112.10 Mil. Therefore, Caribou Biosciences's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -89.51%.
The historical rank and industry rank for Caribou Biosciences's Return-on-Tangible-Equity or its related term are showing as below:
CRBU'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -313.96 Med: -42.36 Max: -28.87
Current: -88.88
During the past 7 years, Caribou Biosciences's highest Return-on-Tangible-Equity was -28.87%. The lowest was -313.96%. And the median was -42.36%.
CRBU's Return-on-Tangible-Equity is ranked worse than 70.31% of 1199
companies
in the Biotechnology industry
Industry Median: -42.4
vs CRBU: -88.88
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Caribou Biosciences Return-on-Tangible-Equity Related Terms
Caribou Biosciences Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Caribou Biosciences's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
CRBU vs YDES, PRQR, CRBP: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Caribou Biosciences's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Caribou Biosciences Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Caribou Biosciences's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Caribou Biosciences's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -89.51% mean?
Caribou Biosciences (CRBU) has a Return-on-Tangible-Equity of -89.51% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Caribou Biosciences and its competitors. According to the industry distribution chart, Caribou Biosciences ranks #843 out of 1199 companies in the Biotechnology industry, placing it in the top 70.3%.
Is Caribou Biosciences' Return-on-Tangible-Equity too high?
Caribou Biosciences' current Return-on-Tangible-Equity is -89.51%. Based on the distribution chart, Caribou Biosciences ranks #843 out of 1199 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Caribou Biosciences has a GF Score™ of 65/100 and is considered Fairly Valued, reflecting its overall financial health beyond just this single metric.
How does Caribou Biosciences' Return-on-Tangible-Equity compare to YDES and PRQR?
According to the Biotechnology industry distribution chart, Caribou Biosciences ranks #843 out of 1199 companies for Return-on-Tangible-Equity. This places Caribou Biosciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Caribou Biosciences and its competitors. Caribou Biosciences's current Return-on-Tangible-Equity is -89.51%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Caribou Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Caribou Biosciences (CRBU) is currently considered Fairly Valued. The stock's GF Value™ is $1.68, compared to a current price of $1.66 — trading 1.5% below its estimated fair value. The current Return-on-Tangible-Equity is -89.51%. Caribou Biosciences' overall GF Score™ is 65/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Caribou Biosciences (CRBU), the current Return-on-Tangible-Equity is -89.51% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Caribou Biosciences (CRBU) Overvalued in 2026?
Based on GuruFocus' analysis, Caribou Biosciences stock appears to be undervalued.
The current stock price of $1.66 is trading 1.5% below its estimated GF Value™ of $1.68.
GuruFocus considers Caribou Biosciences to be Fairly Valued.
Key valuation signals for CRBU:
Return-on-Tangible-Equity: -89.51%
GF Value™: $1.68 vs. price of $1.66 (1.5% below fair value)
No single metric tells the full story. See the CRBU stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Caribou Biosciences Inc is a clinical-stage Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome-editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. The company is focused on advancing two clinical-stage allogeneic CAR-T cell therapy product candidates for the treatment of patients with hematologic malignancies: Vispacabtagene regedleucel and CB-011. It operates in one reportable segment, which is the business of developing allogeneic CAR-T cell therapies. Geographically, it operates in the United States and the rest of the World, of which the United States derives the maximum revenue.
65GF Score
Get the complete analysis for CRBU
Return-on-Tangible-Equity is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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