LYEL (Lyell Immunopharma) OCF Yield %: -41.40 (As of Jul. 22, 2026)

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LYEL Lyell Immunopharma Inc LYEL
55 GF Score
Price $13.19
GF Value $5.26
Valuation Significantly Overvalued
! 6 Warning Signs
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What is Lyell Immunopharma OCF Yield %?

Lyell Immunopharma LYEL +1.47% 55 OCF Yield % is -41.40 as of Jul. 22, 2026. GuruFocus rates LYEL with a GF Score™ of 55/100 and a GF Value™ of $5.26 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,410 Biotechnology companies, Lyell Immunopharma ranks worse than 81.56% on this metric.

OCF Yield % is calculated as Cash Flow from Operations divided by Market Capitalization. It is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

As of today, Lyell Immunopharma's Trailing 12-Month Cash Flow from Operations is $-133.80 Mil, and Market Cap is $323.21 Mil. Therefore, Lyell Immunopharma's OCF Yield % for today is -41.40%.

The historical rank and industry rank for Lyell Immunopharma's OCF Yield % or its related term are showing as below:

LYEL' s OCF Yield % Range Over the Past 10 Years
Min: -148.35   Med: -29.12   Max: -3.59
Current: -41.4


During the past 7 years, the highest OCF Yield % of Lyell Immunopharma was -3.59%. The lowest was -148.35%. And the median was -29.12%.

LYEL's OCF Yield % is ranked worse than
81.56% of 1410 companies
in the Biotechnology industry
Industry Median: -8.505 vs LYEL: -41.40

Lyell Immunopharma's OCF Margin % for the quarter that ended in Mar. 2026 was %.


Lyell Immunopharma OCF Yield % Explanation

Similar to Earnings Yield %, OCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high operating cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Lyell Immunopharma OCF Yield % Related Terms


Lyell Immunopharma OCF Yield % Historical Data

* Premium members only.

The historical data trend for Lyell Immunopharma's OCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Lyell Immunopharma OCF Yield % Chart

Lyell Immunopharma Annual Data
Trend Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
OCF Yield %
Get a 7-Day Free Trial -6.72 -19.58 -33.23 -86.05 -22.94

Lyell Immunopharma Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
OCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -137.83 -105.13 -36.48 -19.72 -32.92

LYEL vs ALXO, ARMP, NAGE: OCF Yield % Comparison

For the Biotechnology subindustry, Lyell Immunopharma's OCF Yield %, along with its competitors' market caps and OCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Lyell Immunopharma OCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Lyell Immunopharma's OCF Yield % distribution charts can be found below:

* The bar in red indicates where Lyell Immunopharma's OCF Yield % falls into.


LYEL
55GF Score
Lyell Immunopharma Inc LYEL
OCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Lyell Immunopharma OCF Yield % Calculation

OCF Yield % is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

Lyell Immunopharma's OCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

OCF Yield %=Cash Flow from Operations / Market Cap
=-150.024 / 654.10578
=-22.94%

Lyell Immunopharma's annualized OCF Yield % for the quarter that ended in Mar. 2026 is calculated as

OCF Yield %=Cash Flow from Operations * Annualized Factor / Market Cap
=-38.51 * 4 / 467.95968
=-32.92%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about OCF Yield % →
What does a OCF Yield % of -41.40 mean?
Lyell Immunopharma (LYEL) has a OCF Yield % of -41.40 as of Jul. 22, 2026. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Lyell Immunopharma and its competitors. According to the industry distribution chart, Lyell Immunopharma ranks #1150 out of 1410 companies in the Biotechnology industry, placing it in the top 81.6%.
Is Lyell Immunopharma's OCF Yield % too high?
Lyell Immunopharma's current OCF Yield % is -41.40. Based on the distribution chart, Lyell Immunopharma ranks #1150 out of 1410 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Lyell Immunopharma has a GF Score™ of 55/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Lyell Immunopharma's OCF Yield % compare to ALXO and ARMP?
According to the Biotechnology industry distribution chart, Lyell Immunopharma ranks #1150 out of 1410 companies for OCF Yield %. This places Lyell Immunopharma in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good OCF Yield % for a Biotechnology company?
A good OCF Yield % depends on the Biotechnology industry context. However, OCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high OCF Yield % mean?
A high OCF Yield % can signal that a stock is expensive relative to its fundamentals. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Lyell Immunopharma and its competitors. Lyell Immunopharma's current OCF Yield % is -41.40. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Lyell Immunopharma stock overvalued right now?
Based on GuruFocus' analysis, Lyell Immunopharma (LYEL) is currently considered Significantly Overvalued. The stock's GF Value™ is $5.26, compared to a current price of $13.19 — trading 150.8% above its estimated fair value. The current OCF Yield % is -41.40. Lyell Immunopharma's overall GF Score™ is 55/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is OCF Yield % calculated?
OCF Yield % is calculated from a company's financial statements. For Lyell Immunopharma (LYEL), the current OCF Yield % is -41.40 as of Jul. 22, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Lyell Immunopharma (LYEL) Overvalued in 2026?

Based on GuruFocus' analysis, Lyell Immunopharma stock appears to be overvalued. The current stock price of $13.19 is trading 150.8% above its estimated GF Value™ of $5.26. GuruFocus considers Lyell Immunopharma to be Significantly Overvalued.

Key valuation signals for LYEL:

  • OCF Yield %: -41.40
  • GF Value™: $5.26 vs. price of $13.19 (150.8% above fair value)
  • GF Score™: 55/100 with 6 warning signs

No single metric tells the full story. See the LYEL stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Lyell Immunopharma Business Description

Address 201 Haskins Way, South San Francisco, CA, USA, 94080
Lyell Immunopharma Inc s a late-stage clinical cell therapy company advancing a pipeline of proprietary next-generation autologous chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors. The Company's product candidate, rondecabtagene autoleucel (ronde-cel, also known as LYL314), is an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development for large B-cell lymphoma (LBCL). The Company has recently acquired exclusive rights outside of mainland China, Hong Kong, Macau and Taiwan, to a novel guanylyl cyclase C (GCC)-targeted CAR T-cell product candidate in early clinical development for refractory metastatic colorectal cancer (mCRC) and other GCC-expressing cancers.
55GF Score

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OCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$13.19
Price
$5.26
GF Value