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Nano HoldingsTSE:4571 44 Debt-to-EBITDA is -1.41 as of Mar. 2026. GuruFocus rates TSE:4571 with a GF Score™ of 44/100 and a GF Value™ of 円186.72 (Possible Value Trap). The stock has 5 warning signs investors should review. Among 297 Biotechnology companies, Nano Holdings ranks worse than 336700% on this metric.
Debt-to-EBITDA measures a company's ability to pay off its debt.
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt. According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
The historical rank and industry rank for Nano Holdings's Debt-to-EBITDA or its related term are showing as below:
TSE:4571'
s Debt-to-EBITDA Range Over the Past 10 Years
Min: -1.75 Med: -0.91 Max: -0.47
Current: -1.21
During the past 13 years, the highest Debt-to-EBITDA Ratio of Nano Holdings was -0.47. The lowest was -1.75. And the median was -0.91.
TSE:4571's Debt-to-EBITDA is ranked worse than 100% of 297
companies
in the Biotechnology industry
Industry Median: 1.16
vs TSE:4571: -1.21
A high Debt-to-EBITDA ratio generally means that a company may spend more time to paying off its debt.
According to Joel Tillinghast's BIG MONEY THINKS SMALL: Biases, Blind Spots, and Smarter Investing, a ratio of Debt-to-EBITDA exceeding four is usually considered scary unless tangible assets cover the debt.
Nano Holdings Debt-to-EBITDA Related Terms
Nano Holdings Debt-to-EBITDA Historical Data
* Premium members only.
The historical data trend for Nano Holdings's Debt-to-EBITDA can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TSE:4571 vs VRTX, REGN, RVMD: Debt-to-EBITDA Comparison
For the Biotechnology subindustry, Nano Holdings's Debt-to-EBITDA, along with its competitors' market caps and Debt-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Nano Holdings Debt-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Nano Holdings's Debt-to-EBITDA distribution charts can be found below:
* The bar in red indicates where Nano Holdings's Debt-to-EBITDA falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Debt-to-EBITDA, the EBITDA of the last fiscal year is used. In calculating the annualized quarterly data,
the EBITDA data used here is four times the quarterly (Mar. 2026) EBITDA data.
Nano Holdings (TSE:4571) has a Debt-to-EBITDA of -1.41 as of Mar. 2026. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Nano Holdings. According to the industry distribution chart, Nano Holdings ranks #999999 out of 297 companies in the Biotechnology industry.
Is Nano Holdings' Debt-to-EBITDA too high?
Nano Holdings' current Debt-to-EBITDA is -1.41. Based on the distribution chart, Nano Holdings ranks #999999 out of 297 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Nano Holdings has a GF Score™ of 44/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Nano Holdings' Debt-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Nano Holdings ranks #999999 out of 297 companies for Debt-to-EBITDA. This places Nano Holdings in the lower half of its industry. The industry median Debt-to-EBITDA is 1.16. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-EBITDA for a Biotechnology company?
The median Debt-to-EBITDA among Biotechnology companies is 1.16, based on 297 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-EBITDA mean?
A high Debt-to-EBITDA can signal that a stock is expensive relative to its fundamentals. Debt-to-EBITDA ratio represents the ratio of total debt to total earnings before interest, taxes, depreciation and amortization. View historical data on Nano Holdings. For the Biotechnology industry, the median Debt-to-EBITDA is 1.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Nano Holdings's current Debt-to-EBITDA is -1.41. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Nano Holdings stock overvalued right now?
Based on GuruFocus' analysis, Nano Holdings (TSE:4571) is currently considered Possible Value Trap. The stock's GF Value™ is 円186.72, compared to a current price of 円102.00 — trading 45.4% below its estimated fair value. The current Debt-to-EBITDA is -1.41. Nano Holdings' overall GF Score™ is 44/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-EBITDA calculated?
Debt-to-EBITDA is calculated from a company's financial statements. For Nano Holdings (TSE:4571), the current Debt-to-EBITDA is -1.41 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Nano Holdings (TSE:4571) Overvalued in 2026?
Based on GuruFocus' analysis, Nano Holdings stock appears to be undervalued.
The current stock price of 円102.00 is trading 45.4% below its estimated GF Value™ of 円186.72.
GuruFocus considers Nano Holdings to be Possible Value Trap.
Key valuation signals for TSE:4571:
Debt-to-EBITDA: -1.41
GF Value™: 円186.72 vs. price of 円102.00 (45.4% below fair value)
No single metric tells the full story. See the TSE:4571 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Nano Holdings Inc formerly, Nano Mrna Co Ltd is engaged in the research and development of pharmaceuticals using micellar nanoparticle technology. The Group's business is a single segment that involves research and development, manufacturing, and sales of pharmaceuticals and other products, as well as related operations.
44GF Score
Get the complete analysis for TSE:4571
Debt-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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