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Nano HoldingsTSE:4571 +2.04%43 3-Year ROIIC % is 142.77 as of Mar. 2026, which is 211% above its 10-year median of 45.98. GuruFocus rates TSE:4571 with a GF Score™ of 43/100 and a GF Value™ of 円187.42 (Possible Value Trap). The stock has 5 warning signs investors should review. Among 1,322 Biotechnology companies, Nano Holdings ranks better than 81.32% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Nano Holdings's 3-Year ROIIC % for the quarter that ended in Mar. 2026 was 142.77%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Nano Holdings's 3-Year ROIIC % or its related term are showing as below:
TSE:4571's 3-Year ROIIC % is ranked better than 81.32% of 1322
companies
in the Biotechnology industry
Industry Median: -4.9
vs TSE:4571: 142.77
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Nano Holdings 3-Year ROIIC % Related Terms
Nano Holdings 3-Year ROIIC % Historical Data
* Premium members only.
The historical data trend for Nano Holdings's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TSE:4571 vs VRTX, REGN, ALNY: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Nano Holdings's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Nano Holdings 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Nano Holdings's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Nano Holdings's 3-Year ROIIC % falls into.
Nano Holdings's 3-Year ROIIC % for the quarter that ended in Mar. 2026 is calculated as:
3-Year ROIIC %
=
3-Year Incremental Net Operating Profit After Taxes (NOPAT)**
/
3-Year Incremental Invested Capital**
=
( -965.988 (Mar. 2026) - -1246 (Mar. 2023) )
/
( 1664.066 (Mar. 2026) - 1467.938 (Mar. 2023) )
=
280.012
/
196.128
=
142.77%***
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Nano Holdings (TSE:4571) has a 3-Year ROIIC % of 142.77 as of Mar. 2026. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Nano Holdings and its competitors. This is 211% above median its historical median of 45.98. According to the industry distribution chart, Nano Holdings ranks #247 out of 1322 companies in the Biotechnology industry, placing it in the top 18.7%.
Is Nano Holdings' 3-Year ROIIC % too high?
Nano Holdings' current 3-Year ROIIC % of 142.77 is 211% above median its 10-year median of 45.98. Based on the distribution chart, Nano Holdings ranks #247 out of 1322 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Nano Holdings has a GF Score™ of 43/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Nano Holdings' 3-Year ROIIC % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Nano Holdings ranks #247 out of 1322 companies for 3-Year ROIIC %. This places Nano Holdings in the top 19% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Nano Holdings and its competitors. Nano Holdings's current 3-Year ROIIC % is 142.77, which is 211% above median its own 10-year median of 45.98. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Nano Holdings stock overvalued right now?
Based on GuruFocus' analysis, Nano Holdings (TSE:4571) is currently considered Possible Value Trap. The stock's GF Value™ is 円187.42, compared to a current price of 円100.00 — trading 46.6% below its estimated fair value. The current 3-Year ROIIC % is 142.77, which is 211% above median its 10-year median of 45.98. Nano Holdings' overall GF Score™ is 43/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Nano Holdings (TSE:4571), the current 3-Year ROIIC % is 142.77 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Nano Holdings (TSE:4571) Overvalued in 2026?
Based on GuruFocus' analysis, Nano Holdings stock appears to be undervalued.
The current stock price of 円100.00 is trading 46.6% below its estimated GF Value™ of 円187.42.
GuruFocus considers Nano Holdings to be Possible Value Trap.
Key valuation signals for TSE:4571:
3-Year ROIIC %: 142.77 (211% above median its 10-year median of 45.98)
GF Value™: 円187.42 vs. price of 円100.00 (46.6% below fair value)
No single metric tells the full story. See the TSE:4571 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Nano Holdings Inc formerly, Nano Mrna Co Ltd is engaged in the research and development of pharmaceuticals using micellar nanoparticle technology. The Group's business is a single segment that involves research and development, manufacturing, and sales of pharmaceuticals and other products, as well as related operations.
43GF Score
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