Nano HoldingsTSE:4571 43 Operating Margin % is -833.52% as of Mar. 2026. GuruFocus rates TSE:4571 with a GF Score™ of 43/100 and a GF Value™ of 円187.93 (Possible Value Trap). The stock has 5 warning signs investors should review. Among 936 Biotechnology companies, Nano Holdings ranks worse than 71.15% on this metric.
Operating Margin % is calculated as Operating Income divided by its Revenue. Nano Holdings's Operating Income for the
three
months ended in Mar. 2026 was 円-363.1 Mil. Nano Holdings's Revenue for the
three
months ended in Mar. 2026 was 円43.6 Mil. Therefore, Nano Holdings's Operating Margin % for the quarter that ended in Mar. 2026 was -833.52%.
Warning Sign:
Nano Holdings Inc operating margin has been in a 5-year decline. The average rate of decline per year is -3.3%.
The historical rank and industry rank for Nano Holdings's Operating Margin % or its related term are showing as below:
TSE:4571'
s Operating Margin % Range Over the Past 10 Years
Min: -2065.42 Med: -627.09 Max: -199.97
Current: -553.58
TSE:4571's Operating Margin % is ranked worse than 71.15% of 936
companies
in the Biotechnology industry
Industry Median: -86.55
vs TSE:4571: -553.58
Nano Holdings's 5-Year Average Operating Margin % Growth Rate was -3.30% per year.
Nano Holdings's Operating Income for the
three
months ended in Mar. 2026 was 円-363.1 Mil.
Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was 円-966.0 Mil.
Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.
Be Aware
Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).
If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.
For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokias Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).
Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.
Nano Holdings Operating Margin % Related Terms
Nano Holdings Operating Margin % Historical Data
* Premium members only.
The historical data trend for Nano Holdings's Operating Margin % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
TSE:4571 vs VRTX, REGN, ALNY: Operating Margin % Comparison
For the Biotechnology subindustry, Nano Holdings's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Nano Holdings Operating Margin % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Nano Holdings's Operating Margin % distribution charts can be found below:
* The bar in red indicates where Nano Holdings's Operating Margin % falls into.
Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.
Nano Holdings's Operating Margin % for the fiscal year that ended in Mar. 2026 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Nano Holdings (TSE:4571) has a Operating Margin % of -833.52% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on Nano Holdings and its competitors. According to the industry distribution chart, Nano Holdings ranks #666 out of 936 companies in the Biotechnology industry, placing it in the top 71.2%.
Is Nano Holdings' Operating Margin % too high?
Nano Holdings' current Operating Margin % is -833.52%. Based on the distribution chart, Nano Holdings ranks #666 out of 936 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Nano Holdings has a GF Score™ of 43/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Nano Holdings' Operating Margin % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, Nano Holdings ranks #666 out of 936 companies for Operating Margin %. This places Nano Holdings in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on Nano Holdings and its competitors. Nano Holdings's current Operating Margin % is -833.52%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Nano Holdings stock overvalued right now?
Based on GuruFocus' analysis, Nano Holdings (TSE:4571) is currently considered Possible Value Trap. The stock's GF Value™ is 円187.93, compared to a current price of 円102.00 — trading 45.7% below its estimated fair value. The current Operating Margin % is -833.52%. Nano Holdings' overall GF Score™ is 43/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For Nano Holdings (TSE:4571), the current Operating Margin % is -833.52% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Nano Holdings (TSE:4571) Overvalued in 2026?
Based on GuruFocus' analysis, Nano Holdings stock appears to be undervalued.
The current stock price of 円102.00 is trading 45.7% below its estimated GF Value™ of 円187.93.
GuruFocus considers Nano Holdings to be Possible Value Trap.
Key valuation signals for TSE:4571:
Operating Margin %: -833.52%
GF Value™: 円187.93 vs. price of 円102.00 (45.7% below fair value)
No single metric tells the full story. See the TSE:4571 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Nano Holdings Inc formerly, Nano Mrna Co Ltd is engaged in the research and development of pharmaceuticals using micellar nanoparticle technology. The Group's business is a single segment that involves research and development, manufacturing, and sales of pharmaceuticals and other products, as well as related operations.
43GF Score
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