Nano Holdings (TSE:4571) ROIC %: -95.24% (As of Mar. 2026)


TSE:4571 Nano Holdings Inc TSE:4571
43 GF Score
Price 円102.00
GF Value 円187.93
Valuation Possible Value Trap
! 5 Warning Signs
View Full Analysis

What is Nano Holdings ROIC %?

Nano Holdings TSE:4571 43 ROIC % is -95.24% as of Mar. 2026. GuruFocus rates TSE:4571 with a GF Score™ of 43/100 and a GF Value™ of 円187.93 (Possible Value Trap). The stock has 5 warning signs investors should review.

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. Nano Holdings's annualized return on invested capital (ROIC %) for the quarter that ended in Mar. 2026 was -95.24%.

As of today (2026-07-06), Nano Holdings's WACC % is 6.06%. Nano Holdings's ROIC % is -65.01% (calculated using TTM income statement data). Nano Holdings earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Nano Holdings  (TSE:4571) ROIC % Explanation

ROIC % measures how well a company generates cash flow relative to the capital it has invested in its business. It is also called ROC %. The reason book values of debt and equity are used is because the book values are the capital the company received when issuing the debt or receiving the equity investments.

There are four key components to this definition. The first is the use of operating income or EBIT rather than net income in the numerator. The second is the tax adjustment to this operating income or EBIT, computed as a hypothetical tax based on an effective or marginal tax rate. The third is the use of book values for invested capital, rather than market values. The final is the timing difference; the capital invested is from the end of the prior year whereas the operating income or EBIT is the current year's number.

Why is ROIC % important?

Because it costs money to raise capital. A firm that generates higher returns on investment than it costs the company to raise the capital needed for that investment is earning excess returns. A firm that expects to continue generating positive excess returns on new investments in the future will see its value increase as growth increases, whereas a firm that earns returns that do not match up to its cost of capital will destroy value as it grows.

As of today, Nano Holdings's WACC % is 6.06%. Nano Holdings's ROIC % is -65.01% (calculated using TTM income statement data). Nano Holdings earns returns that do not match up to its cost of capital. It will destroy value as it grows.


Be Aware

Like ROE % and ROA %, ROIC % is calculated with only 12 months of data. Fluctuations in the company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.


Nano Holdings ROIC % Related Terms


Nano Holdings ROIC % Historical Data

* Premium members only.

The historical data trend for Nano Holdings's ROIC % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Nano Holdings ROIC % Chart

Nano Holdings Annual Data
Trend Mar17 Mar18 Mar19 Mar20 Mar21 Mar22 Mar23 Mar24 Mar25 Mar26
ROIC %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -177.95 -99.66 -67.90 -57.24 -59.90

Nano Holdings Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROIC % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -67.92 -48.07 -59.42 -62.55 -95.24

TSE:4571 vs VRTX, REGN, ALNY: ROIC % Comparison

For the Biotechnology subindustry, Nano Holdings's ROIC %, along with its competitors' market caps and ROIC % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Nano Holdings ROIC % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Nano Holdings's ROIC % distribution charts can be found below:

* The bar in red indicates where Nano Holdings's ROIC % falls into.


TSE:4571
43GF Score
Nano Holdings Inc TSE:4571
ROIC % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Nano Holdings ROIC % Calculation

Nano Holdings's annualized Return on Invested Capital (ROIC %) for the fiscal year that ended in Mar. 2026 is calculated as:

ROIC % (A: Mar. 2026 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (A: Mar. 2025 ) + Invested Capital (A: Mar. 2026 ))/ count )
=-965.988 * ( 1 - 0% )/( (1561.033 + 1664.066)/ 2 )
=-965.988/1612.5495
=-59.90 %

where

Invested Capital(A: Mar. 2025 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=3996.884 - 17.63 - ( 3505.832 - max(0, 1203.432 - 3621.653+3505.832))
=1561.033

Invested Capital(A: Mar. 2026 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=5906.339 - 27.012 - ( 4910.354 - max(0, 983.767 - 5199.028+4910.354))
=1664.066

Nano Holdings's annualized Return on Invested Capital (ROIC %) for the quarter that ended in Mar. 2026 is calculated as:

ROIC % (Q: Mar. 2026 )
=NOPAT/Average Invested Capital
=Operating Income * ( 1 - Tax Rate % )/( (Invested Capital (Q: Dec. 2025 ) + Invested Capital (Q: Mar. 2026 ))/ count )
=-1452.232 * ( 1 - 0% )/( (1385.623 + 1664.066)/ 2 )
=-1452.232/1524.8445
=-95.24 %

where

Invested Capital(Q: Dec. 2025 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=5954.691 - 11.282 - ( 5269.568 - max(0, 924.249 - 5482.035+5269.568))
=1385.623

Invested Capital(Q: Mar. 2026 )
=Total Assets - Accounts Payable & Accrued Expense - Excess Cash
=Total Assets - Accounts Payable & Accrued Expense - ( Cash, Cash Equivalents, Marketable Securities - max(0, Total Current Liabilities - Total Current Assets+Cash, Cash Equivalents, Marketable Securities))
=5906.339 - 27.012 - ( 4910.354 - max(0, 983.767 - 5199.028+4910.354))
=1664.066

Note: The Operating Income data used here is four times the quarterly (Mar. 2026) data. The tax rate is limited to between 0% and 100%.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about ROIC % →
What does a ROIC % of -95.24% mean?
Nano Holdings (TSE:4571) has a ROIC % of -95.24% as of Mar. 2026. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Nano Holdings and its competitors.
Is Nano Holdings' ROIC % too high?
Nano Holdings' current ROIC % is -95.24%. Overall, Nano Holdings has a GF Score™ of 43/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Nano Holdings' ROIC % compare to VRTX and REGN?
Nano Holdings' ROIC % of -95.24% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROIC % for a Biotechnology company?
A good ROIC % depends on the Biotechnology industry context. However, ROIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROIC % mean?
A high ROIC % can signal that a stock is expensive relative to its fundamentals. Return on invested capital is the ratio of current-period net income to average two-period invested capital. View historical data on Nano Holdings and its competitors. Nano Holdings's current ROIC % is -95.24%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Nano Holdings stock overvalued right now?
Based on GuruFocus' analysis, Nano Holdings (TSE:4571) is currently considered Possible Value Trap. The stock's GF Value™ is 円187.93, compared to a current price of 円102.00 — trading 45.7% below its estimated fair value. The current ROIC % is -95.24%. Nano Holdings' overall GF Score™ is 43/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROIC % calculated?
ROIC % is calculated from a company's financial statements. For Nano Holdings (TSE:4571), the current ROIC % is -95.24% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Nano Holdings (TSE:4571) Overvalued in 2026?

Based on GuruFocus' analysis, Nano Holdings stock appears to be undervalued. The current stock price of 円102.00 is trading 45.7% below its estimated GF Value™ of 円187.93. GuruFocus considers Nano Holdings to be Possible Value Trap.

Key valuation signals for TSE:4571:

  • ROIC %: -95.24%
  • GF Value™: 円187.93 vs. price of 円102.00 (45.7% below fair value)
  • GF Score™: 43/100 with 5 warning signs

No single metric tells the full story. See the TSE:4571 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Nano Holdings Business Description

Other Exchanges 3NQ:Germany
Address 2-5-1 Atago, Minato-ku, Chiba, JPN, 277-0882
Nano Holdings Inc formerly, Nano Mrna Co Ltd is engaged in the research and development of pharmaceuticals using micellar nanoparticle technology. The Group's business is a single segment that involves research and development, manufacturing, and sales of pharmaceuticals and other products, as well as related operations.
43GF Score

Get the complete analysis for TSE:4571

ROIC % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円102.00
Price
円187.93
GF Value