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AnnexonANNX +2.94%34 Debt-to-Equity is 0.12 as of Mar. 2026, which is 8% below its 10-year median of 0.13. GuruFocus rates ANNX with a GF Score™ of 34/100. The stock has 2 warning signs investors should review. Among 968 Biotechnology companies, Annexon ranks better than 57.02% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Annexon's Debt-to-Equity or its related term are showing as below:
ANNX'
s Debt-to-Equity Range Over the Past 10 Years
Min: 0.08 Med: 0.13 Max: 0.2
Current: 0.12
During the past 8 years, the highest Debt-to-Equity Ratio of Annexon was 0.20. The lowest was 0.08. And the median was 0.13.
ANNX's Debt-to-Equity is ranked better than 57.02% of 968
companies
in the Biotechnology industry
Industry Median: 0.16
vs ANNX: 0.12
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Annexon Debt-to-Equity Related Terms
Annexon Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Annexon's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ANNX vs ABUS, TBPH, SANA: Debt-to-Equity Comparison
For the Biotechnology subindustry, Annexon's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Annexon Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Annexon's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Annexon's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Annexon (ANNX) has a Debt-to-Equity of 0.12 as of Mar. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Annexon and its competitors. This is near median its historical median of 0.13. Over the past decade, Annexon's Debt-to-Equity has ranged from 0.08 to 0.20. According to the industry distribution chart, Annexon ranks #416 out of 968 companies in the Biotechnology industry, placing it in the top 43%.
Is Annexon's Debt-to-Equity too high?
Annexon's current Debt-to-Equity of 0.12 is near median its 10-year median of 0.13. Over the past 10 years, this metric has ranged from a low of 0.08 to a high of 0.20. The Biotechnology industry median Debt-to-Equity is 0.16. Annexon's value of 0.12 is 25% below this industry median. Based on the distribution chart, Annexon ranks #416 out of 968 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Annexon has a GF Score™ of 34/100, reflecting its overall financial health beyond just this single metric.
How does Annexon's Debt-to-Equity compare to ABUS and TBPH?
According to the Biotechnology industry distribution chart, Annexon ranks #416 out of 968 companies for Debt-to-Equity. This puts Annexon in the upper half of its industry. The industry median Debt-to-Equity is 0.16. Annexon's value of 0.12 is 25% below this benchmark. Historically, Annexon's own Debt-to-Equity has ranged from 0.08 to 0.20 over the past decade. While the company's 10-year median is 0.13 vs. the industry median of 0.16, Annexon has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 968 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Annexon's current Debt-to-Equity of 0.12 is 25% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Annexon and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Annexon's current Debt-to-Equity is 0.12, which is near median its own 10-year median of 0.13. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Annexon stock overvalued right now?
Annexon (ANNX) has a current Debt-to-Equity of 0.12. The current Debt-to-Equity is 0.12, which is near median its 10-year median of 0.13 and 25% below the Biotechnology industry median of 0.16. Annexon's overall GF Score™ is 34/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Annexon (ANNX), the current Debt-to-Equity is 0.12 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Annexon Inc is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, brain, and eye. Its pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q. Its pipeline of product candidates is designed to block the activity of C1q and the entire classical complement pathway in a broad set of complement-mediated diseases. Its product candidates are ANX005, for autoimmune & neurodegenerative disorders; ANX007, for neurodegenerative ophthalmic disorders; ANX1502, for Oral small molecule; and ANX009, for systemic autoimmune diseases.
34GF Score
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