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AnnexonANNX +1.52%34 EV-to-OCF is -3.68 as of Aug. 04, 2026. GuruFocus rates ANNX with a GF Score™ of 34/100. The stock has 2 warning signs investors should review. Among 1,411 Biotechnology companies, Annexon ranks better than 51.38% on this metric.
EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, Annexon's Enterprise Value is $673.69 Mil.
Annexon's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 was $-183.10 Mil. Therefore, Annexon's EV-to-OCF for today is -3.68.
The historical rank and industry rank for Annexon's EV-to-OCF or its related term are showing as below:
ANNX'
s EV-to-OCF Range Over the Past 10 Years
Min: -3.79 Med: 0 Max: -3.61
Current: -3.68
During the past 8 years, the highest EV-to-OCF of Annexon was -3.61. The lowest was -3.79. And the median was .
ANNX's EV-to-OCF is ranked better than 51.38% of 1411
companies
in the Biotechnology industry
Industry Median: -3.32
vs ANNX: -3.68
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Annexon's share price for today is $5.33.
Annexon's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-1.220.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Annexon EV-to-OCF Related Terms
Annexon EV-to-OCF Historical Data
* Premium members only.
The historical data trend for Annexon's EV-to-OCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Annexon's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Annexon EV-to-OCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Annexon's EV-to-OCF distribution charts can be found below:
* The bar in red indicates where Annexon's EV-to-OCF falls into.
Annexon's current Enterprise Value is $673.69 Mil.
Annexon's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-183.10 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Annexon (ANNX) has a EV-to-OCF of -3.68 as of Aug. 04, 2026. According to the industry distribution chart, Annexon ranks #686 out of 1411 companies in the Biotechnology industry, placing it in the top 48.6%.
Is Annexon's EV-to-OCF too high?
Annexon's current EV-to-OCF is -3.68. Based on the distribution chart, Annexon ranks #686 out of 1411 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Annexon has a GF Score™ of 34/100, reflecting its overall financial health beyond just this single metric.
How does Annexon's EV-to-OCF compare to ABUS and TBPH?
According to the Biotechnology industry distribution chart, Annexon ranks #686 out of 1411 companies for EV-to-OCF. This puts Annexon in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Biotechnology company?
A good EV-to-OCF depends on the Biotechnology industry context. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. Annexon's current EV-to-OCF is -3.68. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Annexon stock overvalued right now?
Annexon (ANNX) has a current EV-to-OCF of -3.68. The current EV-to-OCF is -3.68. Annexon's overall GF Score™ is 34/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For Annexon (ANNX), the current EV-to-OCF is -3.68 as of Aug. 04, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Annexon Inc is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, brain, and eye. Its pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q. Its pipeline of product candidates is designed to block the activity of C1q and the entire classical complement pathway in a broad set of complement-mediated diseases. Its product candidates are ANX005, for autoimmune & neurodegenerative disorders; ANX007, for neurodegenerative ophthalmic disorders; ANX1502, for Oral small molecule; and ANX009, for systemic autoimmune diseases.
34GF Score
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