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Stoke TherapeuticsSTOK +2.38%45 Debt-to-Equity is 0.01 as of Mar. 2026, which is at its 10-year median of 0.01. GuruFocus rates STOK with a GF Score™ of 45/100 and a GF Value™ of $10.06 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 966 Biotechnology companies, Stoke Therapeutics ranks better than 99.9% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Stoke Therapeutics's Debt-to-Equity or its related term are showing as below:
STOK'
s Debt-to-Equity Range Over the Past 10 Years
Min: 0 Med: 0.01 Max: 0.02
Current: 0.01
During the past 9 years, the highest Debt-to-Equity Ratio of Stoke Therapeutics was 0.02. The lowest was 0.00. And the median was 0.01.
STOK's Debt-to-Equity is ranked better than 99.9% of 966
companies
in the Biotechnology industry
Industry Median: 0.16
vs STOK: 0.01
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Stoke Therapeutics Debt-to-Equity Related Terms
Stoke Therapeutics Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Stoke Therapeutics's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STOK vs VRDN, ZLAB, NUVB: Debt-to-Equity Comparison
For the Biotechnology subindustry, Stoke Therapeutics's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Stoke Therapeutics Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Stoke Therapeutics's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Stoke Therapeutics's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Stoke Therapeutics (STOK) has a Debt-to-Equity of 0.01 as of Mar. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Stoke Therapeutics and its competitors. This is near median its historical median of 0.01. According to the industry distribution chart, Stoke Therapeutics ranks #1 out of 966 companies in the Biotechnology industry, placing it in the top 0.099999999999994%.
Is Stoke Therapeutics' Debt-to-Equity too high?
Stoke Therapeutics' current Debt-to-Equity of 0.01 is near median its 10-year median of 0.01. The Biotechnology industry median Debt-to-Equity is 0.16. Stoke Therapeutics' value of 0.01 is 93.8% below this industry median. Based on the distribution chart, Stoke Therapeutics ranks #1 out of 966 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Stoke Therapeutics has a GF Score™ of 45/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Stoke Therapeutics' Debt-to-Equity compare to VRDN and ZLAB?
According to the Biotechnology industry distribution chart, Stoke Therapeutics ranks #1 out of 966 companies for Debt-to-Equity. This places Stoke Therapeutics in the top 0% of its industry — outperforming the majority of peers. The industry median Debt-to-Equity is 0.16. Stoke Therapeutics' value of 0.01 is 93.8% below this benchmark. While the company's 10-year median is 0.01 vs. the industry median of 0.16, Stoke Therapeutics has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 966 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Stoke Therapeutics's current Debt-to-Equity of 0.01 is 93.8% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Stoke Therapeutics and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Stoke Therapeutics's current Debt-to-Equity is 0.01, which is near median its own 10-year median of 0.01. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Stoke Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Stoke Therapeutics (STOK) is currently considered Significantly Overvalued. The stock's GF Value™ is $10.06, compared to a current price of $29.65 — trading 194.7% above its estimated fair value. The current Debt-to-Equity is 0.01, which is near median its 10-year median of 0.01 and 93.8% below the Biotechnology industry median of 0.16. Stoke Therapeutics' overall GF Score™ is 45/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Stoke Therapeutics (STOK), the current Debt-to-Equity is 0.01 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Stoke Therapeutics (STOK) Overvalued in 2026?
Based on GuruFocus' analysis, Stoke Therapeutics stock appears to be overvalued.
The current stock price of $29.65 is trading 194.7% above its estimated GF Value™ of $10.06.
GuruFocus considers Stoke Therapeutics to be Significantly Overvalued.
Key valuation signals for STOK:
Debt-to-Equity: 0.01 (near median its 10-year median of 0.01)
GF Value™: $10.06 vs. price of $29.65 (194.7% above fair value)
Industry Position: 93.8% below the Biotechnology median (#1 of 966)
No single metric tells the full story. See the STOK stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Stoke Therapeutics Inc is a biotechnology company dedicated to restoring protein expression by harnessing the bodys potential with RNA medicine. Its proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to restore naturally-occurring protein levels selectively. Its first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome. The company provides early programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye, to up-regulate the protein expression of the underlying disease gene in a mutation-agnostic manner.
45GF Score
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