Stoke TherapeuticsSTOK +0.76%45 Return-on-Tangible-Equity is -53.53% as of Mar. 2026. GuruFocus rates STOK with a GF Score™ of 45/100 and a GF Value™ of $10.15 (Significantly Overvalued). The stock has 5 warning signs investors should review. Among 1,200 Biotechnology companies, Stoke Therapeutics ranks worse than 53.33% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Stoke Therapeutics's annualized net income for the quarter that ended in Mar. 2026 was $-200.01 Mil. Stoke Therapeutics's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $373.67 Mil. Therefore, Stoke Therapeutics's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -53.53%.
The historical rank and industry rank for Stoke Therapeutics's Return-on-Tangible-Equity or its related term are showing as below:
STOK'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -60.8 Med: -29.1 Max: -2.37
Current: -48.77
During the past 9 years, Stoke Therapeutics's highest Return-on-Tangible-Equity was -2.37%. The lowest was -60.80%. And the median was -29.10%.
STOK's Return-on-Tangible-Equity is ranked worse than 53.33% of 1200
companies
in the Biotechnology industry
Industry Median: -42.435
vs STOK: -48.77
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Stoke Therapeutics Return-on-Tangible-Equity Related Terms
Stoke Therapeutics Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Stoke Therapeutics's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
STOK vs VRDN, ZLAB, NUVB: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Stoke Therapeutics's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Stoke Therapeutics Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Stoke Therapeutics's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Stoke Therapeutics's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -53.53% mean?
Stoke Therapeutics (STOK) has a Return-on-Tangible-Equity of -53.53% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Stoke Therapeutics and its competitors. According to the industry distribution chart, Stoke Therapeutics ranks #640 out of 1200 companies in the Biotechnology industry, placing it in the top 53.3%.
Is Stoke Therapeutics' Return-on-Tangible-Equity too high?
Stoke Therapeutics' current Return-on-Tangible-Equity is -53.53%. Based on the distribution chart, Stoke Therapeutics ranks #640 out of 1200 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Stoke Therapeutics has a GF Score™ of 45/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Stoke Therapeutics' Return-on-Tangible-Equity compare to VRDN and ZLAB?
According to the Biotechnology industry distribution chart, Stoke Therapeutics ranks #640 out of 1200 companies for Return-on-Tangible-Equity. This places Stoke Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Stoke Therapeutics and its competitors. Stoke Therapeutics's current Return-on-Tangible-Equity is -53.53%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Stoke Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Stoke Therapeutics (STOK) is currently considered Significantly Overvalued. The stock's GF Value™ is $10.15, compared to a current price of $32.98 — trading 224.9% above its estimated fair value. The current Return-on-Tangible-Equity is -53.53%. Stoke Therapeutics' overall GF Score™ is 45/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Stoke Therapeutics (STOK), the current Return-on-Tangible-Equity is -53.53% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Stoke Therapeutics (STOK) Overvalued in 2026?
Based on GuruFocus' analysis, Stoke Therapeutics stock appears to be overvalued.
The current stock price of $32.98 is trading 224.9% above its estimated GF Value™ of $10.15.
GuruFocus considers Stoke Therapeutics to be Significantly Overvalued.
Key valuation signals for STOK:
Return-on-Tangible-Equity: -53.53%
GF Value™: $10.15 vs. price of $32.98 (224.9% above fair value)
No single metric tells the full story. See the STOK stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Stoke Therapeutics Inc is a biotechnology company dedicated to restoring protein expression by harnessing the bodys potential with RNA medicine. Its proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to restore naturally-occurring protein levels selectively. Its first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome. The company provides early programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye, to up-regulate the protein expression of the underlying disease gene in a mutation-agnostic manner.
45GF Score
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