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During the past 3 years, the average EPS without NRIGrowth Rate was 23.80% per year.
During the past 5 years, the average EPS without NRIGrowth Rate was 18.10% per year.
During the past 10 years, the average EPS without NRIGrowth Rate was 12.00% per year.
During the past 13 years, Karyopharm Therapeutics's highest 3-Year average EPS without NRI Growth Rate was 23.80% per year. The lowest was -32.20% per year. And the median was 5.80% per year.
Karyopharm Therapeutics (NAS:KPTI) Earnings per Share (Diluted) Explanation
Earnings Per Share (EPS) is the single most important variable used by Wall Street in determining the earnings power of a company. But investors need to be aware that Earnings per Share can be easily manipulated by adjusting depreciation and amortization rate or non-recurring items. That's why GuruFocus lists EPS without NRI, which better reflects the company's underlying performance.
Be Aware
Compared with Earnings per share, a company's cash flow is better indicator of the company's earnings power.
If a company's earnings per share is less than cash flow per share over long term, investors need to be cautious and find out why.
Karyopharm Therapeutics Earnings per Share (Diluted) Related Terms
Karyopharm Therapeutics Earnings per Share (Diluted) Historical Data
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The historical data trend for Karyopharm Therapeutics's Earnings per Share (Diluted) can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Karyopharm Therapeutics Earnings per Share (Diluted) Chart
KPTI vs ALGS, EDSA, FLNA: Earnings per Share (Diluted) Comparison
For the Biotechnology subindustry, Karyopharm Therapeutics's PE Ratio, along with its competitors' market caps and PE Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Karyopharm Therapeutics PE Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Karyopharm Therapeutics's PE Ratio distribution charts can be found below:
* The bar in red indicates where Karyopharm Therapeutics's PE Ratio falls into.
Karyopharm Therapeutics Earnings per Share (Diluted) Calculation
Earnings Per Share (EPS) is the amount of earnings per outstanding share of the company's stock. In calculating earnings per share, the dividends of preferred stocks need to subtracted from the total net income first.
Karyopharm Therapeutics's Earnings Per Share (Diluted) for the fiscal year that ended in Dec. 2025 is calculated as
Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-13.09
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Companies also reported diluted shares in their financial reports. Diluted shares include the shares of convertibles or warrants outstanding.
What does a Earnings per Share (Diluted) of $-13.09 mean?
Karyopharm Therapeutics (KPTI) has a Earnings per Share (Diluted) of $-13.09 as of Jun. 2026. Diluted EPS equals net earnings divided by average shares outstanding, including dilutive securities. View historical data on Karyopharm Therapeutics and its competitors. According to the industry distribution chart, Karyopharm Therapeutics ranks #465 out of 1160 companies in the Biotechnology industry, placing it in the top 40.1%.
Is Karyopharm Therapeutics' Earnings per Share (Diluted) too high?
Karyopharm Therapeutics' current Earnings per Share (Diluted) is $-13.09. Based on the distribution chart, Karyopharm Therapeutics ranks #465 out of 1160 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Karyopharm Therapeutics has a GF Score™ of 45/100 and is considered Possible Value Trap, reflecting its overall financial health beyond just this single metric.
How does Karyopharm Therapeutics' Earnings per Share (Diluted) compare to ALGS and EDSA?
According to the Biotechnology industry distribution chart, Karyopharm Therapeutics ranks #465 out of 1160 companies for Earnings per Share (Diluted). This puts Karyopharm Therapeutics in the upper half of its industry. The industry median Earnings per Share (Diluted) is 16.05. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Earnings per Share (Diluted) for a Biotechnology company?
The median Earnings per Share (Diluted) among Biotechnology companies is 16.05, based on 1,160 companies in the industry. Companies in the top quartile (top 25%) have a Earnings per Share (Diluted) significantly above this median, while those in the bottom quartile fall well below. However, Earnings per Share (Diluted) should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Earnings per Share (Diluted) mean?
A high Earnings per Share (Diluted) can signal that a stock is expensive relative to its fundamentals. Diluted EPS equals net earnings divided by average shares outstanding, including dilutive securities. View historical data on Karyopharm Therapeutics and its competitors. For the Biotechnology industry, the median Earnings per Share (Diluted) is 16.05 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Karyopharm Therapeutics's current Earnings per Share (Diluted) is $-13.09. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Karyopharm Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Karyopharm Therapeutics (KPTI) is currently considered Possible Value Trap. The stock's GF Value™ is $4.58, compared to a current price of $1.68 — trading 63.3% below its estimated fair value. The current Earnings per Share (Diluted) is $-13.09. Karyopharm Therapeutics' overall GF Score™ is 45/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Earnings per Share (Diluted) calculated?
Earnings per Share (Diluted) is calculated from a company's financial statements. For Karyopharm Therapeutics (KPTI), the current Earnings per Share (Diluted) is $-13.09 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Karyopharm Therapeutics (KPTI) Overvalued in 2026?
Based on GuruFocus' analysis, Karyopharm Therapeutics stock appears to be undervalued.
The current stock price of $1.68 is trading 63.3% below its estimated GF Value™ of $4.58.
GuruFocus considers Karyopharm Therapeutics to be Possible Value Trap.
Key valuation signals for KPTI:
Earnings per Share (Diluted): $-13.09
GF Value™: $4.58 vs. price of $1.68 (63.3% below fair value)
No single metric tells the full story. See the KPTI stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
45GF Score
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