KPTI (Karyopharm Therapeutics) FCF Yield %: -26.70 (As of Jul. 01, 2026)


KPTI Karyopharm Therapeutics Inc KPTI
52 GF Score
Price $9.77
GF Value $6.39
Valuation Significantly Overvalued
! 8 Warning Signs
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What is Karyopharm Therapeutics FCF Yield %?

Karyopharm Therapeutics KPTI +0.15% 52 FCF Yield % is -26.70 as of Jul. 01, 2026. GuruFocus rates KPTI with a GF Score™ of 52/100 and a GF Value™ of $6.39 (Significantly Overvalued). The stock has 8 warning signs investors should review. Among 1,414 Biotechnology companies, Karyopharm Therapeutics ranks worse than 72.98% on this metric.

FCF Yield % is calculated as Free Cash Flow divided by Market Capitalization. It is a financial solvency ratio that compares the free cash flow a company is expected to earn against its market value.

As of today, Karyopharm Therapeutics's Trailing 12-Month Free Cash Flow is $-59.1 Mil, and Market Cap is $221.4 Mil. Therefore, Karyopharm Therapeutics's FCF Yield % for today is -26.70%.

The historical rank and industry rank for Karyopharm Therapeutics's FCF Yield % or its related term are showing as below:

KPTI' s FCF Yield % Range Over the Past 10 Years
Min: -375.43   Med: -26.52   Max: -8.5
Current: -26.7


During the past 13 years, the highest FCF Yield % of Karyopharm Therapeutics was -8.50%. The lowest was -375.43%. And the median was -26.52%.

KPTI's FCF Yield % is ranked worse than
72.98% of 1414 companies
in the Biotechnology industry
Industry Median: -9.46 vs KPTI: -26.70

Karyopharm Therapeutics's FCF Margin % for the quarter that ended in Mar. 2026 was -64.81%.


Karyopharm Therapeutics FCF Yield % Explanation

Similar to Earnings Yield %, FCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high free cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Karyopharm Therapeutics FCF Yield % Related Terms


Karyopharm Therapeutics FCF Yield % Historical Data

* Premium members only.

The historical data trend for Karyopharm Therapeutics's FCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Karyopharm Therapeutics FCF Yield % Chart

Karyopharm Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
FCF Yield %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -23.16 -38.88 -93.28 -149.54 -55.92

Karyopharm Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
FCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -486.63 -200.67 -41.19 -35.11 -72.40

KPTI vs CHRS, TARA, CNTN: FCF Yield % Comparison

For the Biotechnology subindustry, Karyopharm Therapeutics's FCF Yield %, along with its competitors' market caps and FCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Karyopharm Therapeutics FCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Karyopharm Therapeutics's FCF Yield % distribution charts can be found below:

* The bar in red indicates where Karyopharm Therapeutics's FCF Yield % falls into.


KPTI
52GF Score
Karyopharm Therapeutics Inc KPTI
FCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Karyopharm Therapeutics FCF Yield % Calculation

FCF Yield % is a financial solvency ratio that compares the free cash flow a company is expected to earn against its market value.

Karyopharm Therapeutics's FCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

FCF Yield %=Free Cash Flow / Market Cap
=-75.369 / 134.76896
=-55.92%

Karyopharm Therapeutics's annualized FCF Yield % for the quarter that ended in Mar. 2026 is calculated as

FCF Yield %=Free Cash Flow * Annualized Factor / Market Cap
=-22.728 * 4 / 125.57008
=-72.40%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about FCF Yield % →
What does a FCF Yield % of -26.70 mean?
Karyopharm Therapeutics (KPTI) has a FCF Yield % of -26.70 as of Jul. 01, 2026. FCF Yield is calculated as Free Cash Flow divided by Market Capitalization. View historical data on Karyopharm Therapeutics and its competitors. According to the industry distribution chart, Karyopharm Therapeutics ranks #1032 out of 1414 companies in the Biotechnology industry, placing it in the top 73%.
Is Karyopharm Therapeutics' FCF Yield % too high?
Karyopharm Therapeutics' current FCF Yield % is -26.70. Based on the distribution chart, Karyopharm Therapeutics ranks #1032 out of 1414 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Karyopharm Therapeutics has a GF Score™ of 52/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Karyopharm Therapeutics' FCF Yield % compare to CHRS and TARA?
According to the Biotechnology industry distribution chart, Karyopharm Therapeutics ranks #1032 out of 1414 companies for FCF Yield %. This places Karyopharm Therapeutics in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good FCF Yield % for a Biotechnology company?
A good FCF Yield % depends on the Biotechnology industry context. However, FCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high FCF Yield % mean?
A high FCF Yield % can signal that a stock is expensive relative to its fundamentals. FCF Yield is calculated as Free Cash Flow divided by Market Capitalization. View historical data on Karyopharm Therapeutics and its competitors. Karyopharm Therapeutics's current FCF Yield % is -26.70. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Karyopharm Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Karyopharm Therapeutics (KPTI) is currently considered Significantly Overvalued. The stock's GF Value™ is $6.39, compared to a current price of $9.77 — trading 52.9% above its estimated fair value. The current FCF Yield % is -26.70. Karyopharm Therapeutics' overall GF Score™ is 52/100 with 8 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is FCF Yield % calculated?
FCF Yield % is calculated from a company's financial statements. For Karyopharm Therapeutics (KPTI), the current FCF Yield % is -26.70 as of Jul. 01, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Karyopharm Therapeutics (KPTI) Overvalued in 2026?

Based on GuruFocus' analysis, Karyopharm Therapeutics stock appears to be overvalued. The current stock price of $9.77 is trading 52.9% above its estimated GF Value™ of $6.39. GuruFocus considers Karyopharm Therapeutics to be Significantly Overvalued.

Key valuation signals for KPTI:

  • FCF Yield %: -26.70
  • GF Value™: $6.39 vs. price of $9.77 (52.9% above fair value)
  • GF Score™: 52/100 with 8 warning signs

No single metric tells the full story. See the KPTI stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Karyopharm Therapeutics Business Description

Other Exchanges 25K0:Germany
Address 85 Wells Avenue, 2nd Floor, Newton, MA, USA, 02459
Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
52GF Score

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FCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$9.77
Price
$6.39
GF Value