KPTI (Karyopharm Therapeutics) Effective Interest Rate on Debt %: 21.62% (As of Mar. 2026)

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KPTI Karyopharm Therapeutics Inc KPTI
56 GF Score
Price $7.10
GF Value $6.03
Valuation Modestly Overvalued
! 6 Warning Signs
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What is Karyopharm Therapeutics Effective Interest Rate on Debt %?

Karyopharm Therapeutics KPTI -1.18% 56 Effective Interest Rate on Debt % is 21.62% as of Mar. 2026. GuruFocus rates KPTI with a GF Score™ of 56/100 and a GF Value™ of $6.03 (Modestly Overvalued). The stock has 6 warning signs investors should review.

Effective Interest Rate on Debt % is the usage rate that a borrower actually pays on a debt. It is calculated as the positive value of Interest Expense divided by its average total debt. Total debt equals to Long-Term Debt & Capital Lease Obligation plus Short-Term Debt & Capital Lease Obligation. Karyopharm Therapeutics's annualized positive value of Interest Expense for the quarter that ended in Mar. 2026 was $50.2 Mil. Karyopharm Therapeutics's average total debt for the quarter that ended in Mar. 2026 was $232.2 Mil. Therefore, Karyopharm Therapeutics's annualized Effective Interest Rate on Debt % for the quarter that ended in Mar. 2026 was 21.62%.


Karyopharm Therapeutics  (NAS:KPTI) Effective Interest Rate on Debt % Explanation

Effective Interest Rate on Debt % measures the usage rate that a borrower actually pays on a debt.


Karyopharm Therapeutics Effective Interest Rate on Debt % Related Terms


Karyopharm Therapeutics Effective Interest Rate on Debt % Historical Data

* Premium members only.

The historical data trend for Karyopharm Therapeutics's Effective Interest Rate on Debt % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Karyopharm Therapeutics Effective Interest Rate on Debt % Chart

Karyopharm Therapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Effective Interest Rate on Debt %
Get a 7-Day Free Trial Premium Member Only Premium Member Only 16.71 13.90 13.38 20.14 21.42

Karyopharm Therapeutics Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Effective Interest Rate on Debt % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 23.07 23.81 22.75 23.48 21.62

KPTI vs CHRS, TARA, CNTN: Effective Interest Rate on Debt % Comparison

For the Biotechnology subindustry, Karyopharm Therapeutics's Effective Interest Rate on Debt %, along with its competitors' market caps and Effective Interest Rate on Debt % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Karyopharm Therapeutics Effective Interest Rate on Debt % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Karyopharm Therapeutics's Effective Interest Rate on Debt % distribution charts can be found below:

* The bar in red indicates where Karyopharm Therapeutics's Effective Interest Rate on Debt % falls into.


KPTI
56GF Score
Karyopharm Therapeutics Inc KPTI
Effective Interest Rate on Debt % is just one metric. See GF Score™, valuation, warning signs, and more.
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Karyopharm Therapeutics Effective Interest Rate on Debt % Calculation

Karyopharm Therapeutics's annualized Effective Interest Rate on Debt % for the fiscal year that ended in Dec. 2025 is calculated as

Effective Interest Rate on Debt %
=-1  *  Interest Expense/( (Total Debt  (A: Dec. 2024 )+Total Debt  (A: Dec. 2025 ))/ count )
=-1  *  -45.849/( (194.524+233.607)/ 2 )
=-1  *  -45.849/214.0655
=21.42 %

where

Total Debt  (A: Dec. 2024 )
=Long-Term Debt & Capital Lease Obligation + Short-Term Debt & Capital Lease Obligation
=169.66 + 24.864
=194.524

Total Debt  (A: Dec. 2025 )
=Long-Term Debt & Capital Lease Obligation + Short-Term Debt & Capital Lease Obligation
=211.628 + 21.979
=233.607

Karyopharm Therapeutics's annualized Effective Interest Rate on Debt % for the quarter that ended in Mar. 2026 is calculated as

Effective Interest Rate on Debt %
=-1  *  Interest Expense/( (Total Debt  (Q: Dec. 2025 )+Total Debt  (Q: Mar. 2026 ))/ count )
=-1  *  -50.212/( (233.607+230.874)/ 2 )
=-1  *  -50.212/232.2405
=21.62 %

where

Total Debt  (Q: Dec. 2025 )
=Long-Term Debt & Capital Lease Obligation + Short-Term Debt & Capital Lease Obligation
=211.628 + 21.979
=233.607

Total Debt  (Q: Mar. 2026 )
=Long-Term Debt & Capital Lease Obligation + Short-Term Debt & Capital Lease Obligation
=197.624 + 33.25
=230.874

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual Effective Interest Rate on Debt %, the Interest Expense of the last fiscal year and the average total debt over the fiscal year are used. In calculating the quarterly data, the Interest Expense data used here is four times the quarterly (Mar. 2026) interest expense data. Effective Interest Rate on Debt % is displayed in the 30-year financial page.

What does a Effective Interest Rate on Debt % of 21.62% mean?
Karyopharm Therapeutics (KPTI) has a Effective Interest Rate on Debt % of 21.62% as of Mar. 2026. Effective interest rate on debt is the rate a company actually pays on its debt. View historical data on Karyopharm Therapeutics and its competitors.
Is Karyopharm Therapeutics' Effective Interest Rate on Debt % too high?
Karyopharm Therapeutics' current Effective Interest Rate on Debt % is 21.62%. Overall, Karyopharm Therapeutics has a GF Score™ of 56/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Karyopharm Therapeutics' Effective Interest Rate on Debt % compare to CHRS and TARA?
Karyopharm Therapeutics' Effective Interest Rate on Debt % of 21.62% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Effective Interest Rate on Debt % for a Biotechnology company?
A good Effective Interest Rate on Debt % depends on the Biotechnology industry context. However, Effective Interest Rate on Debt % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Effective Interest Rate on Debt % mean?
A high Effective Interest Rate on Debt % can signal that a stock is expensive relative to its fundamentals. Effective interest rate on debt is the rate a company actually pays on its debt. View historical data on Karyopharm Therapeutics and its competitors. Karyopharm Therapeutics's current Effective Interest Rate on Debt % is 21.62%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Karyopharm Therapeutics stock overvalued right now?
Based on GuruFocus' analysis, Karyopharm Therapeutics (KPTI) is currently considered Modestly Overvalued. The stock's GF Value™ is $6.03, compared to a current price of $7.10 — trading 17.7% above its estimated fair value. The current Effective Interest Rate on Debt % is 21.62%. Karyopharm Therapeutics' overall GF Score™ is 56/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Effective Interest Rate on Debt % calculated?
Effective Interest Rate on Debt % is calculated from a company's financial statements. For Karyopharm Therapeutics (KPTI), the current Effective Interest Rate on Debt % is 21.62% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Karyopharm Therapeutics (KPTI) Overvalued in 2026?

Based on GuruFocus' analysis, Karyopharm Therapeutics stock appears to be overvalued. The current stock price of $7.10 is trading 17.7% above its estimated GF Value™ of $6.03. GuruFocus considers Karyopharm Therapeutics to be Modestly Overvalued.

Key valuation signals for KPTI:

  • Effective Interest Rate on Debt %: 21.62%
  • GF Value™: $6.03 vs. price of $7.10 (17.7% above fair value)
  • GF Score™: 56/100 with 6 warning signs

No single metric tells the full story. See the KPTI stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Karyopharm Therapeutics Business Description

Other Exchanges 25K0:Germany
Address 85 Wells Avenue, 2nd Floor, Newton, MA, USA, 02459
Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
56GF Score

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Effective Interest Rate on Debt % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$7.10
Price
$6.03
GF Value