OPKO Health (LTS:0KCS) Shiller PE Ratio: (As of Sep. 03, 2026)

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Director of Data and Quant Analytics at GuruFocus
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LTS:0KCS OPKO Health Inc LTS:0KCS
48 GF Score
Price $1.69
GF Value $1.12
Valuation Significantly Overvalued
! 8 Warning Signs
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What is OPKO Health Shiller PE Ratio?

Shiller PE for Stocks: The True Measure of Stock Valuation


OPKO Health  (LTS:0KCS) Shiller PE Ratio Explanation

Compared with the regular PE Ratio, which works poorly for cyclical businesses, the Shiller PE Ratio smoothed out the fluctuations of profit margins during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Shiller PE Ratio should give similar results to regular PE Ratio.

Compared with the PS Ratio, the Shiller PE Ratio makes the comparison between different industries more meaningful.


Be Aware

Shiller PE Ratio assumes that over the long term, businesses and profitability revert to their means. If a company's business model does not work in the future compared with the past, Shiller PE Ratio and PS Ratio will give false valuations.


OPKO Health Shiller PE Ratio Related Terms


OPKO Health Shiller PE Ratio Historical Data

* Premium members only.

The historical data trend for OPKO Health's Shiller PE Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OPKO Health Shiller PE Ratio Chart

OPKO Health Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Shiller PE Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

OPKO Health Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Shiller PE Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

LTS:0KCS vs CSTL, FRNM, FLGT: Shiller PE Ratio Comparison

For the Diagnostics & Research subindustry, OPKO Health's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OPKO Health Shiller PE Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, OPKO Health's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where OPKO Health's Shiller PE Ratio falls into.


LTS:0KCS
48GF Score
OPKO Health Inc LTS:0KCS
Shiller PE Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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OPKO Health Shiller PE Ratio Calculation

For Shiller PE Ratio, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller PE Ratio is also called PE10.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

OPKO Health's E10 for the quarter that ended in Jun. 2026 is calculated as:

For example, OPKO Health's adjusted earnings per share data for the three months ended in Jun. 2026 was:

Adj_EPS=Earnings per Share (Diluted)/CPI of Jun. 2026 (Change)*Current CPI (Jun. 2026)
=-0.01/333.9520*333.9520
=-0.010

Current CPI (Jun. 2026) = 333.9520.

OPKO Health Quarterly Data

Earnings per Share (Diluted) CPI Adj_EPS
201609 -0.030 241.428 -0.041
201612 -0.040 241.432 -0.055
201703 -0.060 243.801 -0.082
201706 -0.040 244.955 -0.055
201709 -0.060 246.819 -0.081
201712 -0.380 246.524 -0.515
201803 -0.080 249.554 -0.107
201806 -0.010 251.989 -0.013
201809 -0.050 252.439 -0.066
201812 -0.130 251.233 -0.173
201903 -0.140 254.202 -0.184
201906 -0.100 256.143 -0.130
201909 -0.110 256.759 -0.143
201912 -0.180 256.974 -0.234
202003 -0.090 258.115 -0.116
202006 0.050 257.797 0.065
202009 0.040 260.280 0.051
202012 0.050 260.474 0.064
202103 0.050 264.877 0.063
202106 -0.030 271.696 -0.037
202109 0.040 274.310 0.049
202112 -0.110 278.802 -0.132
202203 -0.080 287.504 -0.093
202206 -0.140 296.311 -0.158
202209 -0.110 296.808 -0.124
202212 -0.110 296.797 -0.124
202303 -0.020 301.836 -0.022
202306 -0.030 305.109 -0.033
202309 -0.110 307.789 -0.119
202312 -0.090 306.746 -0.098
202403 -0.120 312.332 -0.128
202406 -0.010 314.175 -0.011
202409 0.030 315.301 0.032
202412 0.010 315.605 0.011
202503 -0.100 319.799 -0.104
202506 -0.190 322.561 -0.197
202509 0.030 324.800 0.031
202512 -0.040 324.054 -0.041
202603 -0.070 330.213 -0.071
202606 -0.010 333.952 -0.010

Add all the adjusted EPS together and divide 10 will get our E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

Is OPKO Health (LTS:0KCS) Overvalued in 2026?

Based on GuruFocus' analysis, OPKO Health stock appears to be overvalued. The current stock price of $1.69 is trading 50.9% above its estimated GF Value™ of $1.12. GuruFocus considers OPKO Health to be Significantly Overvalued.

Key valuation signals for LTS:0KCS:

  • Shiller PE Ratio:
  • GF Value™: $1.12 vs. price of $1.69 (50.9% above fair value)
  • GF Score™: 48/100 with 8 warning signs

No single metric tells the full story. See the LTS:0KCS stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OPKO Health Business Description

Address 4400 Biscayne Boulevard, Miami, FL, USA, 33137
OPKO Health Inc is a diversified biotechnology company that operates pharmaceutical and diagnostic development programs. Its segments include pharmaceutical and diagnostics. The Pharmaceutical segment consists of its pharmaceutical operations in Chile, Mexico, Ireland, Israel, Spain, Ecuador, France, the United States, and its pharmaceutical research and development operations. The Diagnostics segment consists of clinical and genomics laboratory operations through BioReference and point-of-care operations. It generates the majority of its revenue from the Diagnostics segment.
48GF Score

Get the complete analysis for LTS:0KCS

Shiller PE Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.69
Price
$1.12
GF Value