OPKO Health (LTS:0KCS) 3-Year Sortino Ratio: -0.20 (As of Sep. 01, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

LTS:0KCS OPKO Health Inc LTS:0KCS
51 GF Score
Price $1.47
GF Value $1.12
Valuation Significantly Overvalued
! 8 Warning Signs
View Full Analysis

What is OPKO Health 3-Year Sortino Ratio?

OPKO Health LTS:0KCS 51 3-Year Sortino Ratio is -0.20 as of Sep. 01, 2026. GuruFocus rates LTS:0KCS with a GF Score™ of 51/100 and a GF Value™ of $1.12 (Significantly Overvalued). The stock has 8 warning signs investors should review.

The 3-Year Sortino Ratio measures the additional return that an investor receives per unit of the downside risk over the past three years. As of today (2026-09-01), OPKO Health's 3-Year Sortino Ratio is -0.20.


OPKO Health  (LTS:0KCS) 3-Year Sortino Ratio Explanation

The 3-Year Sortino Ratio inidicates the risk-adjusted return of an investment over the past three year. It is calculated as the annualized result of the average three-year monthly excess returns divided by the standard deviation of negative returns in the three-year period. The monthly excess return is the monthly investment return minus the monthly risk-free rate (typically the 10-year Treasury Constant Maturity Rate). If the risk-free rate for a specific region is not available, U.S. data is used by default.

Differnt from the Sharpe Ratio that penalizes both upside and downside volatility equally, the Sortino Ratio penalizes only those returns falling below a user-specified target or required rate of return. The expected returns here is set to the risk-free rate as well.


OPKO Health 3-Year Sortino Ratio Related Terms


LTS:0KCS vs CSTL, FRNM, FLGT: 3-Year Sortino Ratio Comparison

For the Diagnostics & Research subindustry, OPKO Health's 3-Year Sortino Ratio, along with its competitors' market caps and 3-Year Sortino Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OPKO Health 3-Year Sortino Ratio vs Medical Diagnostics & Research Industry

For the Medical Diagnostics & Research industry and Healthcare sector, OPKO Health's 3-Year Sortino Ratio distribution charts can be found below:

* The bar in red indicates where OPKO Health's 3-Year Sortino Ratio falls into.


LTS:0KCS
51GF Score
OPKO Health Inc LTS:0KCS
3-Year Sortino Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

OPKO Health 3-Year Sortino Ratio Calculation

The 3-Year Sortino Ratio measures the risk-adjusted return of an investment asset or portfolio in the last three year, focusing specifically on downside risk rather than total risk. A stock / portfolio's 3-Year Sortino Ratio can be calculated by dividing the difference between the three-year average monthly returns of the investment and the risk-free rate, by the standard deviation of the downside risks over the past three year.

A downside risk is a potential loss from the asset or investment. The Downside risk here is measured by the downside deviation, which is the standard deviation of negative returns.

Frequently Asked Questions Learn more about 3-Year Sortino Ratio →
What does a 3-Year Sortino Ratio of -0.20 mean?
OPKO Health (LTS:0KCS) has a 3-Year Sortino Ratio of -0.20 as of Sep. 01, 2026. 3-Year Sortino Ratio measures the additional return that an investor receives per unit of the downside risk over the past three years. View historical data for OPKO Health and its competitors.
Is OPKO Health's 3-Year Sortino Ratio too high?
OPKO Health's current 3-Year Sortino Ratio is -0.20. Overall, OPKO Health has a GF Score™ of 51/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OPKO Health's 3-Year Sortino Ratio compare to CSTL and FRNM?
OPKO Health's 3-Year Sortino Ratio of -0.20 can be compared against companies in the Medical Diagnostics & Research industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year Sortino Ratio for a Medical Diagnostics & Research company?
A good 3-Year Sortino Ratio depends on the Medical Diagnostics & Research industry context. However, 3-Year Sortino Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year Sortino Ratio mean?
A high 3-Year Sortino Ratio can signal that a stock is expensive relative to its fundamentals. 3-Year Sortino Ratio measures the additional return that an investor receives per unit of the downside risk over the past three years. View historical data for OPKO Health and its competitors. OPKO Health's current 3-Year Sortino Ratio is -0.20. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OPKO Health stock overvalued right now?
Based on GuruFocus' analysis, OPKO Health (LTS:0KCS) is currently considered Significantly Overvalued. The stock's GF Value™ is $1.12, compared to a current price of $1.47 — trading 31.3% above its estimated fair value. The current 3-Year Sortino Ratio is -0.20. OPKO Health's overall GF Score™ is 51/100 with 8 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year Sortino Ratio calculated?
3-Year Sortino Ratio is calculated from a company's financial statements. For OPKO Health (LTS:0KCS), the current 3-Year Sortino Ratio is -0.20 as of Sep. 01, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OPKO Health (LTS:0KCS) Overvalued in 2026?

Based on GuruFocus' analysis, OPKO Health stock appears to be overvalued. The current stock price of $1.47 is trading 31.3% above its estimated GF Value™ of $1.12. GuruFocus considers OPKO Health to be Significantly Overvalued.

Key valuation signals for LTS:0KCS:

  • 3-Year Sortino Ratio: -0.20
  • GF Value™: $1.12 vs. price of $1.47 (31.3% above fair value)
  • GF Score™: 51/100 with 8 warning signs

No single metric tells the full story. See the LTS:0KCS stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OPKO Health Business Description

Address 4400 Biscayne Boulevard, Miami, FL, USA, 33137
OPKO Health Inc is a diversified biotechnology company that operates pharmaceutical and diagnostic development programs. Its segments include pharmaceutical and diagnostics. The Pharmaceutical segment consists of its pharmaceutical operations in Chile, Mexico, Ireland, Israel, Spain, Ecuador, France, the United States, and its pharmaceutical research and development operations. The Diagnostics segment consists of clinical and genomics laboratory operations through BioReference and point-of-care operations. It generates the majority of its revenue from the Diagnostics segment.
51GF Score

Get the complete analysis for LTS:0KCS

3-Year Sortino Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.47
Price
$1.12
GF Value