PTIX (Protagenic Therapeutics) Shiller PE Ratio: (As of Sep. 03, 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

PTIX Protagenic Therapeutics Inc PTIX
22 GF Score
Price $1.05
! 2 Warning Signs
View Full Analysis

What is Protagenic Therapeutics Shiller PE Ratio?

Shiller PE for Stocks: The True Measure of Stock Valuation


Protagenic Therapeutics  (OTCPK:PTIX) Shiller PE Ratio Explanation

Compared with the regular PE Ratio, which works poorly for cyclical businesses, the Shiller PE Ratio smoothed out the fluctuations of profit margins during business cycles. Therefore it is more accurate in reflecting the valuation of the company.

If a company has consistent business performance, the Shiller PE Ratio should give similar results to regular PE Ratio.

Compared with the PS Ratio, the Shiller PE Ratio makes the comparison between different industries more meaningful.


Be Aware

Shiller PE Ratio assumes that over the long term, businesses and profitability revert to their means. If a company's business model does not work in the future compared with the past, Shiller PE Ratio and PS Ratio will give false valuations.


Protagenic Therapeutics Shiller PE Ratio Related Terms


Protagenic Therapeutics Shiller PE Ratio Historical Data

* Premium members only.

The historical data trend for Protagenic Therapeutics's Shiller PE Ratio can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Protagenic Therapeutics Shiller PE Ratio Chart

Protagenic Therapeutics Annual Data
Trend Jun14 Jun15 Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23
Shiller PE Ratio
Get a 7-Day Free Trial Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

Protagenic Therapeutics Quarterly Data
Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25
Shiller PE Ratio Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 0.00

PTIX vs SCNI, DCOY, BBLG: Shiller PE Ratio Comparison

For the Biotechnology subindustry, Protagenic Therapeutics's Shiller PE Ratio, along with its competitors' market caps and Shiller PE Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Protagenic Therapeutics Shiller PE Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Protagenic Therapeutics's Shiller PE Ratio distribution charts can be found below:

* The bar in red indicates where Protagenic Therapeutics's Shiller PE Ratio falls into.


PTIX
22GF Score
Protagenic Therapeutics Inc PTIX
Shiller PE Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Protagenic Therapeutics Shiller PE Ratio Calculation

For Shiller PE Ratio, the earnings of the past 10 years are inflation-adjusted and averaged. The result is used for P/E calculation. Since it looks at the average over the last 10 years, the Shiller PE Ratio is also called PE10.

The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The same calculation is applied here to individual companies.

Protagenic Therapeutics's E10 for the quarter that ended in Dec. 2025 is calculated as:

For example, Protagenic Therapeutics's adjusted earnings per share data for the three months ended in Dec. 2025 was:

Adj_EPS=Earnings per Share (Diluted)/CPI of Dec. 2025 (Change)*Current CPI (Dec. 2025)
=1.14/324.0540*324.0540
=1.140

Current CPI (Dec. 2025) = 324.0540.

Protagenic Therapeutics Quarterly Data

Earnings per Share (Diluted) CPI Adj_EPS
201603 -1,594.364 238.132 -2,169.637
201606 -4.480 241.018 -6.023
201609 -3.360 241.428 -4.510
201612 -3.036 241.432 -4.075
201703 -3.360 243.801 -4.466
201706 -2.240 244.955 -2.963
201709 -2.240 246.819 -2.941
201712 -3.920 246.524 -5.153
201803 -3.360 249.554 -4.363
201806 -3.920 251.989 -5.041
201809 -2.800 252.439 -3.594
201812 -4.480 251.233 -5.779
201903 -3.360 254.202 -4.283
201906 -1.680 256.143 -2.125
201909 -0.560 256.759 -0.707
201912 -3.920 256.974 -4.943
202003 -2.800 258.115 -3.515
202006 -3.360 257.797 -4.224
202009 -5.600 260.280 -6.972
202012 -2.800 260.474 -3.483
202103 -6.160 264.877 -7.536
202106 -6.160 271.696 -7.347
202109 -2.800 274.310 -3.308
202112 -2.800 278.802 -3.254
202203 -4.480 287.504 -5.050
202206 -2.100 296.311 -2.297
202209 -2.940 296.808 -3.210
202212 -1.960 296.797 -2.140
202303 -2.380 301.836 -2.555
202306 -3.920 305.109 -4.163
202309 -4.480 307.789 -4.717
202312 -5.320 306.746 -5.620
202403 -5.438 312.332 -5.642
202406 -5.040 314.175 -5.198
202409 -1.960 315.301 -2.014
202412 -3.360 315.605 -3.450
202503 -2.749 319.799 -2.786
202506 -1.370 322.561 -1.376
202509 -0.470 324.800 -0.469
202512 1.140 324.054 1.140

Add all the adjusted EPS together and divide 10 will get our E10.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.


Protagenic Therapeutics Business Description

Address 149 Fifth Avenue, Suite 500, New York, NY, USA, 10010
Protagenic Therapeutics Inc is a biopharmaceutical company focused on the discovery and development of therapeutics to treat stress-related neuropsychiatric and mood disorders. It provides treatments for mood, anxiety, depression, and neurodegenerative disorders by using peptide-based and brain-active therapeutics. The company's main compound, PT00114, is a synthetic form of Teneurin Carboxy-terminal Associated Peptide, an endogenous brain signaling peptide that can dampen overactive stress responses. It has also created a portfolio of novel neuropeptides that are in various stages of development and preclinical evaluation for the treatment of mood disorders.
22GF Score

Get the complete analysis for PTIX

Shiller PE Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$1.05
Price