PTIX (Protagenic Therapeutics) 5-Year Sortino Ratio: -1.28 (As of Sep. 03, 2026)

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PTIX Protagenic Therapeutics Inc PTIX
22 GF Score
Price $1.02
! 2 Warning Signs
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What is Protagenic Therapeutics 5-Year Sortino Ratio?

Protagenic Therapeutics PTIX -2.86% 22 5-Year Sortino Ratio is -1.28 as of Sep. 03, 2026. GuruFocus rates PTIX with a GF Score™ of 22/100. The stock has 2 warning signs investors should review.

The 5-Year Sortino Ratio measures the additional return that an investor receives per unit of the downside risk over the past five years. As of today (2026-09-03), Protagenic Therapeutics's 5-Year Sortino Ratio is -1.28.

Protagenic Therapeutics  (OTCPK:PTIX) 5-Year Sortino Ratio Explanation

The 5-Year Sortino Ratio inidicates the risk-adjusted return of an investment over the past five year. It is calculated as the annualized result of the average five-year monthly excess returns divided by the standard deviation of negative returns in the five-year period. The monthly excess return is the monthly investment return minus the monthly risk-free rate (typically the 10-year Treasury Constant Maturity Rate). If the risk-free rate for a specific region is not available, U.S. data is used by default.

Differnt from the Sharpe Ratio that penalizes both upside and downside volatility equally, the Sortino Ratio penalizes only those returns falling below a user-specified target or required rate of return. The expected returns here is set to the risk-free rate as well.

Protagenic Therapeutics 5-Year Sortino Ratio Related Terms

PTIX vs SCNI, DCOY, BBLG: 5-Year Sortino Ratio Comparison

For the Biotechnology subindustry, Protagenic Therapeutics's 5-Year Sortino Ratio, along with its competitors' market caps and 5-Year Sortino Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Protagenic Therapeutics 5-Year Sortino Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Protagenic Therapeutics's 5-Year Sortino Ratio distribution charts can be found below:

* The bar in red indicates where Protagenic Therapeutics's 5-Year Sortino Ratio falls into.


PTIX
22GF Score
Protagenic Therapeutics Inc PTIX
5-Year Sortino Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Protagenic Therapeutics 5-Year Sortino Ratio Calculation

The 5-Year Sortino Ratio measures the risk-adjusted return of an investment asset or portfolio in the last five year, focusing specifically on downside risk rather than total risk. A stock / portfolio's 5-Year Sortino Ratio can be calculated by dividing the difference between the five-year average monthly returns of the investment and the risk-free rate, by the standard deviation of the downside risks over the past five year.

A downside risk is a potential loss from the asset or investment. The Downside risk here is measured by the downside deviation, which is the standard deviation of negative returns.

Frequently Asked Questions Learn more about 5-Year Sortino Ratio →
What does a 5-Year Sortino Ratio of -1.28 mean?
Protagenic Therapeutics (PTIX) has a 5-Year Sortino Ratio of -1.28 as of Sep. 03, 2026. 5-Year Sortino Ratio measures the additional return that an investor receives per unit of the downside risk over the past five years. View historical data for Protagenic Therapeutics and its competitors.
Is Protagenic Therapeutics' 5-Year Sortino Ratio too high?
Protagenic Therapeutics' current 5-Year Sortino Ratio is -1.28. Overall, Protagenic Therapeutics has a GF Score™ of 22/100, reflecting its overall financial health beyond just this single metric.
How does Protagenic Therapeutics' 5-Year Sortino Ratio compare to SCNI and DCOY?
Protagenic Therapeutics' 5-Year Sortino Ratio of -1.28 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 5-Year Sortino Ratio for a Biotechnology company?
A good 5-Year Sortino Ratio depends on the Biotechnology industry context. However, 5-Year Sortino Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 5-Year Sortino Ratio mean?
A high 5-Year Sortino Ratio can signal that a stock is expensive relative to its fundamentals. 5-Year Sortino Ratio measures the additional return that an investor receives per unit of the downside risk over the past five years. View historical data for Protagenic Therapeutics and its competitors. Protagenic Therapeutics's current 5-Year Sortino Ratio is -1.28. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Protagenic Therapeutics stock overvalued right now?
Protagenic Therapeutics (PTIX) has a current 5-Year Sortino Ratio of -1.28. The current 5-Year Sortino Ratio is -1.28. Protagenic Therapeutics' overall GF Score™ is 22/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 5-Year Sortino Ratio calculated?
5-Year Sortino Ratio is calculated from a company's financial statements. For Protagenic Therapeutics (PTIX), the current 5-Year Sortino Ratio is -1.28 as of Sep. 03, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Protagenic Therapeutics Business Description

Address 149 Fifth Avenue, Suite 500, New York, NY, USA, 10010
Protagenic Therapeutics Inc is a biopharmaceutical company focused on the discovery and development of therapeutics to treat stress-related neuropsychiatric and mood disorders. It provides treatments for mood, anxiety, depression, and neurodegenerative disorders by using peptide-based and brain-active therapeutics. The company's main compound, PT00114, is a synthetic form of Teneurin Carboxy-terminal Associated Peptide, an endogenous brain signaling peptide that can dampen overactive stress responses. It has also created a portfolio of novel neuropeptides that are in various stages of development and preclinical evaluation for the treatment of mood disorders.
22GF Score

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