D. Western Therapeutics Institute (TSE:4576) Cyclically Adjusted Book per Share: 円71.92 (As of Dec. 2025)


TSE:4576 D. Western Therapeutics Institute Inc TSE:4576
44 GF Score
Price 円82.00
GF Value 円63.95
Valuation Modestly Overvalued
! 3 Warning Signs
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What is D. Western Therapeutics Institute Cyclically Adjusted Book per Share?

D. Western Therapeutics Institute TSE:4576 -1.20% 44 Cyclically Adjusted Book per Share is 円71.92 as of Dec. 2025. GuruFocus rates TSE:4576 with a GF Score™ of 44/100 and a GF Value™ of 円63.95 (Modestly Overvalued). The stock has 3 warning signs investors should review.

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

D. Western Therapeutics Institute's adjusted book value per share for the three months ended in Dec. 2025 was 円26.459. Add all the adjusted book value per share for the past 10 years together and divide the count will get our Cyclically Adjusted Book per Share, which is 円71.92 for the trailing ten years ended in Dec. 2025.

During the past 12 months, D. Western Therapeutics Institute's average Cyclically Adjusted Book Growth Rate was -5.90% per year. During the past 3 years, the average Cyclically Adjusted Book Growth Rate was -3.50% per year. During the past 5 years, the average Cyclically Adjusted Book Growth Rate was 0.50% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the Cyclically Adjusted Book Growth Rate using Cyclically Adjusted Book per Share data.

During the past 13 years, the highest 3-Year average Cyclically Adjusted Book Growth Rate of D. Western Therapeutics Institute was 4.10% per year. The lowest was -3.50% per year. And the median was 2.40% per year.

As of today (2026-07-07), D. Western Therapeutics Institute's current stock price is 円82.00. D. Western Therapeutics Institute's Cyclically Adjusted Book per Share for the quarter that ended in Dec. 2025 was 円71.92. D. Western Therapeutics Institute's Cyclically Adjusted PB Ratio of today is 1.14.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of D. Western Therapeutics Institute was 9.06. The lowest was 0.86. And the median was 2.74.


D. Western Therapeutics Institute  (TSE:4576) Cyclically Adjusted Book per Share Explanation

If a company grows much fast than inflation, Cyclically Adjusted Book per Share may underestimate the company's equity. Cyclically Adjusted PB Ratio can seem to be too high even the actual PB Ratio is low.

For the Cyclically Adjusted PB Ratio, the book value of the past 10 years are inflation-adjusted and averaged. The result is used for P/B calculation. Since it looks at the average over the last 10 years, the Cyclically Adjusted PB Ratio is also called CAPB Ratio.

The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted book value per share of a company over the past 10 years.

D. Western Therapeutics Institute's Cyclically Adjusted PB Ratio of today is calculated as

Cyclically Adjusted PB Ratio=Share Price/Cyclically Adjusted Book per Share
=82.00/71.92
=1.14

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

During the past 13 years, the highest Cyclically Adjusted PB Ratio of D. Western Therapeutics Institute was 9.06. The lowest was 0.86. And the median was 2.74.


Be Aware

Cyclically Adjusted PB Ratio works better for cyclical companies. It gives you a better idea on the company's real book value.


D. Western Therapeutics Institute Cyclically Adjusted Book per Share Related Terms


D. Western Therapeutics Institute Cyclically Adjusted Book per Share Historical Data

* Premium members only.

The historical data trend for D. Western Therapeutics Institute's Cyclically Adjusted Book per Share can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

D. Western Therapeutics Institute Cyclically Adjusted Book per Share Chart

D. Western Therapeutics Institute Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cyclically Adjusted Book per Share
Get a 7-Day Free Trial Premium Member Only Premium Member Only 73.80 80.14 79.72 76.39 71.92

D. Western Therapeutics Institute Quarterly Data
Dec20 Mar21 Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Dec24 Mar25 Jun25 Dec25 Mar26
Cyclically Adjusted Book per Share Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only 76.39 74.58 72.89 71.92 0.00

TSE:4576 vs VRTX, REGN, ALNY: Cyclically Adjusted Book per Share Comparison

For the Biotechnology subindustry, D. Western Therapeutics Institute's Cyclically Adjusted PB Ratio, along with its competitors' market caps and Cyclically Adjusted PB Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


D. Western Therapeutics Institute Cyclically Adjusted PB Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, D. Western Therapeutics Institute's Cyclically Adjusted PB Ratio distribution charts can be found below:

* The bar in red indicates where D. Western Therapeutics Institute's Cyclically Adjusted PB Ratio falls into.


TSE:4576
44GF Score
D. Western Therapeutics Institute Inc TSE:4576
Cyclically Adjusted Book per Share is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

D. Western Therapeutics Institute Cyclically Adjusted Book per Share Calculation

E10 is a concept invented by Prof. Robert Shiller, who uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted Book per Share and the Cyclically Adjusted PB Ratio. The Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years.

What is Cyclically Adjusted Book per Share? How do we calculate Cyclically Adjusted Book per Share?

Cyclically Adjusted Book per Share is the average of the inflation adjusted Book Value per Share of a company over the past 10 years. Let's use an example to explain.

If we want to calculate the Cyclically Adjusted Book per Share of Wal-Mart (WMT) for Dec. 31, 2010, we need to have the inflation data and the book value per share from 2001 through 2010.

We adjusted the 2001 book value per share data with the total inflation from 2001 through 2010 to the equivalent book value in 2010. If the total inflation from 2001 to 2010 is 40%, and Wal-Mart's book value is $1 a share in 2001, then the 2001's equivalent book value in 2010 is $1.4 a share. If Wal-Mart's book value is $1 again in 2002, and the total inflation from 2002 through 2010 is 35%, then the equivalent 2002 book value in 2010 is $1.35. So on and so forth, you get the equivalent book value per share of past 10 years. Then you add them together and divided the sum by the count to get Cyclically Adjusted Book per Share.

Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.

For example, D. Western Therapeutics Institute's adjusted Book Value per Share data for the three months ended in Dec. 2025 was:

Adj_Book= Book Value per Share /CPI of Dec. 2025 (Change)*Current CPI (Dec. 2025)
=26.459/113.0000*113.0000
=26.459

Current CPI (Dec. 2025) = 113.0000.

D. Western Therapeutics Institute Quarterly Data

Book Value per Share CPI Adj_Book
201509 84.449 98.500 96.881
201512 83.492 98.100 96.173
201603 81.862 97.900 94.488
201606 116.312 98.100 133.978
201609 113.238 98.000 130.570
201612 110.597 98.400 127.007
201703 130.596 98.100 150.432
201706 88.866 98.500 101.948
201709 84.954 98.800 97.164
201712 76.204 99.400 86.630
201803 69.123 99.200 78.739
201806 62.554 99.200 71.256
201809 54.812 99.900 62.000
201812 47.949 99.700 54.345
201903 53.758 99.700 60.929
201906 53.099 99.800 60.122
201909 52.514 100.100 59.282
201912 53.019 100.500 59.613
202003 51.360 100.300 57.863
202006 49.775 99.900 56.302
202009 78.256 99.900 88.518
202012 73.977 99.300 84.183
202103 73.000 99.900 82.573
202106 71.987 99.500 81.754
202109 69.963 100.100 78.979
202112 68.360 100.100 77.170
202203 67.596 101.100 75.552
202206 64.864 101.800 72.000
202209 61.984 103.100 67.936
202212 60.169 104.100 65.313
202303 59.791 104.400 64.716
202306 56.713 105.200 60.918
202309 51.299 106.200 54.584
202312 39.833 106.800 42.145
202403 29.843 107.200 31.458
202406 25.803 108.200 26.948
202412 17.630 110.700 17.996
202503 22.116 111.100 22.494
202506 19.339 111.700 19.564
202512 26.459 113.000 26.459

Add all the adjusted book value per share together and divide the count will get our Cyclically Adjusted Book per Share.

What does a Cyclically Adjusted Book per Share of 円71.92 mean?
D. Western Therapeutics Institute (TSE:4576) has a Cyclically Adjusted Book per Share of 円71.92 as of Dec. 2025. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on D. Western Therapeutics Institute and its competitors.
Is D. Western Therapeutics Institute's Cyclically Adjusted Book per Share too high?
D. Western Therapeutics Institute's current Cyclically Adjusted Book per Share is 円71.92. Overall, D. Western Therapeutics Institute has a GF Score™ of 44/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does D. Western Therapeutics Institute's Cyclically Adjusted Book per Share compare to VRTX and REGN?
D. Western Therapeutics Institute's Cyclically Adjusted Book per Share of 円71.92 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted Book per Share for a Biotechnology company?
A good Cyclically Adjusted Book per Share depends on the Biotechnology industry context. However, Cyclically Adjusted Book per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted Book per Share mean?
A high Cyclically Adjusted Book per Share can signal that a stock is expensive relative to its fundamentals. Cyclically adjusted book value per share represents the company's inflation-adjusted book value per share over a 10-year period. View historical data on D. Western Therapeutics Institute and its competitors. D. Western Therapeutics Institute's current Cyclically Adjusted Book per Share is 円71.92. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is D. Western Therapeutics Institute stock overvalued right now?
Based on GuruFocus' analysis, D. Western Therapeutics Institute (TSE:4576) is currently considered Modestly Overvalued. The stock's GF Value™ is 円63.95, compared to a current price of 円82.00 — trading 28.2% above its estimated fair value. The current Cyclically Adjusted Book per Share is 円71.92. D. Western Therapeutics Institute's overall GF Score™ is 44/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted Book per Share calculated?
Cyclically Adjusted Book per Share is calculated from a company's financial statements. For D. Western Therapeutics Institute (TSE:4576), the current Cyclically Adjusted Book per Share is 円71.92 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is D. Western Therapeutics Institute (TSE:4576) Overvalued in 2026?

Based on GuruFocus' analysis, D. Western Therapeutics Institute stock appears to be overvalued. The current stock price of 円82.00 is trading 28.2% above its estimated GF Value™ of 円63.95. GuruFocus considers D. Western Therapeutics Institute to be Modestly Overvalued.

Key valuation signals for TSE:4576:

  • Cyclically Adjusted Book per Share: 円71.92
  • GF Value™: 円63.95 vs. price of 円82.00 (28.2% above fair value)
  • GF Score™: 44/100 with 3 warning signs

No single metric tells the full story. See the TSE:4576 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


D. Western Therapeutics Institute Business Description

Other Exchanges 6DW:Germany
Address 7th Floor, 18 KT Bulding, 1-18-11, Nishiki, Naka-ku, Aichi, Nagoyashi, JPN, 460-0003
D. Western Therapeutics Institute Inc is engaged in the research and development of pharmaceutical drugs in Japan. Its products include ophthalmic solution and agents for antiplatelet and anti-glaucoma.
44GF Score

Get the complete analysis for TSE:4576

Cyclically Adjusted Book per Share is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

円82.00
Price
円63.95
GF Value