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D. Western Therapeutics InstituteTSE:4576 46 Cyclically Adjusted PS Ratio is 5.78 as of Aug. 10, 2026, which is 70% below its 10-year median of 19.15. GuruFocus rates TSE:4576 with a GF Score™ of 46/100 and a GF Value™ of 円67.75 (Modestly Overvalued). The stock has 3 warning signs investors should review. Among 539 Biotechnology companies, D. Western Therapeutics Institute ranks worse than 50.65% on this metric.
The historical rank and industry rank for D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio or its related term are showing as below:
TSE:4576'
s Cyclically Adjusted PS Ratio Range Over the Past 10 Years
Min: 5.16 Med: 19.15 Max: 66.26
Current: 5.78
During the past years, D. Western Therapeutics Institute's highest Cyclically Adjusted PS Ratio was 66.26. The lowest was 5.16. And the median was 19.15.
TSE:4576's Cyclically Adjusted PS Ratio is ranked worse than 50.65% of 539
companies
in the Biotechnology industry
Industry Median: 5.71
vs TSE:4576: 5.78
The Shiller PE Ratio was first used by professor Robert Shiller. He uses E10 for his Shiller PE Ratio calculation. E10 is the average of the inflation adjusted earnings per share of a company over the past 10 years. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio. The Cyclically Adjusted Revenue per Share is the average of the inflation adjusted revenue per share of a company over the past 10 years.
D. Western Therapeutics Institute's adjusted revenue per share data for the three months ended in Dec. 2025 was 円1.889. Add all the adjusted revenue per share for the past 10 years together and divide 10 will get our Cyclically Adjusted Revenue per Share, which is 円13.83 for the trailing ten years ended in Dec. 2025.
Shiller PE for Stocks: The True Measure of Stock Valuation
D. Western Therapeutics Institute (TSE:4576) Cyclically Adjusted PS Ratio Explanation
Compared with the regular PS Ratio, which works poorly for cyclical businesses, the Cyclically Adjusted PS Ratio smoothed out the fluctuations of revenue during business cycles. Therefore it is more accurate in reflecting the valuation of the company.
If a company has consistent business performance, the Cyclically Adjusted PS Ratio should give similar results to regular PS Ratio.
D. Western Therapeutics Institute Cyclically Adjusted PS Ratio Related Terms
D. Western Therapeutics Institute Cyclically Adjusted PS Ratio Historical Data
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
D. Western Therapeutics Institute Cyclically Adjusted PS Ratio Chart
TSE:4576 vs VRTX, REGN, RVMD: Cyclically Adjusted PS Ratio Comparison
For the Biotechnology subindustry, D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio, along with its competitors' market caps and Cyclically Adjusted PS Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
D. Western Therapeutics Institute Cyclically Adjusted PS Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio distribution charts can be found below:
* The bar in red indicates where D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio falls into.
D. Western Therapeutics Institute Cyclically Adjusted PS Ratio Calculation
Like the Shiller PE Ratio, the Cyclically Adjusted PS Ratio takes the Revenue per Share from the past 10 years, adjusts it for inflation, and then calculates the average. This average is then used for the P/S calculation. Because it considers this 10-year average, it's often referred to as the CAPS Ratio.
The Shiller PE Ratio was first used by professor Robert Shiller to measure the valuation of the overall market. The similar calculation is applied by GuruFocus to calculate the Cyclically Adjusted PS Ratio.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Please note that we use the CPI data of the country/region where the company is headquartered. If the CPI data for that country/region is not available, then we will use the CPI data of the United States as default.
What does a Cyclically Adjusted PS Ratio of 5.78 mean?
D. Western Therapeutics Institute (TSE:4576) has a Cyclically Adjusted PS Ratio of 5.78 as of Aug. 10, 2026. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on D. Western Therapeutics Institute and its competitors. This is 70% below median its historical median of 19.15. Over the past decade, D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio has ranged from 5.16 to 66.26. According to the industry distribution chart, D. Western Therapeutics Institute ranks #273 out of 539 companies in the Biotechnology industry, placing it in the top 50.6%.
Is D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio too high?
D. Western Therapeutics Institute's current Cyclically Adjusted PS Ratio of 5.78 is 70% below median its 10-year median of 19.15. Over the past 10 years, this metric has ranged from a low of 5.16 to a high of 66.26. The Biotechnology industry median Cyclically Adjusted PS Ratio is 5.71. D. Western Therapeutics Institute's value of 5.78 is 1.2% above this industry median. Based on the distribution chart, D. Western Therapeutics Institute ranks #273 out of 539 companies in the Biotechnology industry, which is below the industry midpoint. Overall, D. Western Therapeutics Institute has a GF Score™ of 46/100 and is considered Modestly Overvalued, reflecting its overall financial health beyond just this single metric.
How does D. Western Therapeutics Institute's Cyclically Adjusted PS Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, D. Western Therapeutics Institute ranks #273 out of 539 companies for Cyclically Adjusted PS Ratio. This places D. Western Therapeutics Institute in the lower half of its industry. The industry median Cyclically Adjusted PS Ratio is 5.71. D. Western Therapeutics Institute's value of 5.78 is 1.2% above this benchmark. Historically, D. Western Therapeutics Institute's own Cyclically Adjusted PS Ratio has ranged from 5.16 to 66.26 over the past decade. While the company's 10-year median is 19.15 vs. the industry median of 5.71, D. Western Therapeutics Institute has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cyclically Adjusted PS Ratio for a Biotechnology company?
The median Cyclically Adjusted PS Ratio among Biotechnology companies is 5.71, based on 539 companies in the industry. Companies in the top quartile (top 25%) have a Cyclically Adjusted PS Ratio significantly above this median, while those in the bottom quartile fall well below. However, Cyclically Adjusted PS Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. D. Western Therapeutics Institute's current Cyclically Adjusted PS Ratio of 5.78 is 1.2% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cyclically Adjusted PS Ratio mean?
A high Cyclically Adjusted PS Ratio can signal that a stock is expensive relative to its fundamentals. Cyclically Adjusted PS Ratio is the ratio of share price to a company's inflation-adjusted revenue per share over a 10-year period. View historical data on D. Western Therapeutics Institute and its competitors. For the Biotechnology industry, the median Cyclically Adjusted PS Ratio is 5.71 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. D. Western Therapeutics Institute's current Cyclically Adjusted PS Ratio is 5.78, which is 70% below median its own 10-year median of 19.15. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is D. Western Therapeutics Institute stock overvalued right now?
Based on GuruFocus' analysis, D. Western Therapeutics Institute (TSE:4576) is currently considered Modestly Overvalued. The stock's GF Value™ is 円67.75, compared to a current price of 円80.00 — trading 18.1% above its estimated fair value. The current Cyclically Adjusted PS Ratio is 5.78, which is 70% below median its 10-year median of 19.15 and 1.2% above the Biotechnology industry median of 5.71. D. Western Therapeutics Institute's overall GF Score™ is 46/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cyclically Adjusted PS Ratio calculated?
Cyclically Adjusted PS Ratio is calculated from a company's financial statements. For D. Western Therapeutics Institute (TSE:4576), the current Cyclically Adjusted PS Ratio is 5.78 as of Aug. 10, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is D. Western Therapeutics Institute (TSE:4576) Overvalued in 2026?
Based on GuruFocus' analysis, D. Western Therapeutics Institute stock appears to be overvalued.
The current stock price of 円80.00 is trading 18.1% above its estimated GF Value™ of 円67.75.
GuruFocus considers D. Western Therapeutics Institute to be Modestly Overvalued.
Key valuation signals for TSE:4576:
Cyclically Adjusted PS Ratio: 5.78 (70% below median its 10-year median of 19.15)
GF Value™: 円67.75 vs. price of 円80.00 (18.1% above fair value)
Industry Position: 1.2% above the Biotechnology median (#273 of 539)
No single metric tells the full story. See the TSE:4576 stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
D. Western Therapeutics Institute Inc is engaged in the research and development of pharmaceutical drugs in Japan. Its products include ophthalmic solution and agents for antiplatelet and anti-glaucoma.
46GF Score
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