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OSE ImmunotherapeuticsORPOF 51 EV-to-EBITDA is -2.78 as of Jul. 22, 2026. GuruFocus rates ORPOF with a GF Score™ of 51/100 and a GF Value™ of $3.31 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 398 Biotechnology companies, OSE Immunotherapeutics ranks worse than 251256.03% on this metric.
EV-to-EBITDA is calculated as enterprise value divided by its EBITDA. As of today, OSE Immunotherapeutics's enterprise value is $101.63 Mil.
OSE Immunotherapeutics's EBITDA for the trailing twelve months (TTM) ended in Dec. 2025 was $-36.50 Mil. Therefore, OSE Immunotherapeutics's EV-to-EBITDA for today is -2.78.
The historical rank and industry rank for OSE Immunotherapeutics's EV-to-EBITDA or its related term are showing as below:
ORPOF'
s EV-to-EBITDA Range Over the Past 10 Years
Min: -154.61 Med: -6 Max: 10.85
Current: -2.84
During the past 13 years, the highest EV-to-EBITDA of OSE Immunotherapeutics was 10.85. The lowest was -154.61. And the median was -6.00.
ORPOF's EV-to-EBITDA is ranked worse than 100% of 398
companies
in the Biotechnology industry
Industry Median: 12.295
vs ORPOF: -2.84
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio to determine the fair market value of a company.
The "classic" EV-to-EBITDA is much better in capturing debt and net cash than the PE Ratio (TTM).
OSE Immunotherapeutics (OTCPK:ORPOF) EV-to-EBITDA Explanation
EV-to-EBITDA is a valuation multiple used in finance and investment to measure the value of a company. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
OSE Immunotherapeutics's PE Ratio (TTM) for today is calculated as:
OSE Immunotherapeutics's share price for today is $4.43.
For company reported semi-annually, GuruFocus uses latest annual data as the TTM data. OSE Immunotherapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Dec. 2025 was $-1.991.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Study has found that the companies with the lowest EV-to-EBITDA outperforms companies measured as cheap by other ratios such as PE Ratio (TTM).
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
ORPOF vs VRTX, REGN, ALNY: EV-to-EBITDA Comparison
For the Biotechnology subindustry, OSE Immunotherapeutics's EV-to-EBITDA, along with its competitors' market caps and EV-to-EBITDA data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
OSE Immunotherapeutics EV-to-EBITDA vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, OSE Immunotherapeutics's EV-to-EBITDA distribution charts can be found below:
* The bar in red indicates where OSE Immunotherapeutics's EV-to-EBITDA falls into.
OSE Immunotherapeutics's current Enterprise Value is $101.63 Mil.
For company reported semi-annually, GuruFocus uses latest annual data as the TTM data. OSE Immunotherapeutics's EBITDA for the trailing twelve months (TTM) ended in Dec. 2025 was $-36.50 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
OSE Immunotherapeutics (ORPOF) has a EV-to-EBITDA of -2.78 as of Jul. 22, 2026. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on OSE Immunotherapeutics. According to the industry distribution chart, OSE Immunotherapeutics ranks #999999 out of 398 companies in the Biotechnology industry.
Is OSE Immunotherapeutics' EV-to-EBITDA too high?
OSE Immunotherapeutics' current EV-to-EBITDA is -2.78. Based on the distribution chart, OSE Immunotherapeutics ranks #999999 out of 398 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, OSE Immunotherapeutics has a GF Score™ of 51/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OSE Immunotherapeutics' EV-to-EBITDA compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, OSE Immunotherapeutics ranks #999999 out of 398 companies for EV-to-EBITDA. This places OSE Immunotherapeutics in the lower half of its industry. The industry median EV-to-EBITDA is 12.30. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBITDA for a Biotechnology company?
The median EV-to-EBITDA among Biotechnology companies is 12.30, based on 398 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBITDA significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBITDA should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBITDA mean?
A high EV-to-EBITDA can signal that a stock is expensive relative to its fundamentals. EV to EBITDA ratio is the company's enterprise value divided by earnings before interest, taxes, depreciation and amortization. View historical data on OSE Immunotherapeutics. For the Biotechnology industry, the median EV-to-EBITDA is 12.30 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. OSE Immunotherapeutics's current EV-to-EBITDA is -2.78. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OSE Immunotherapeutics stock overvalued right now?
Based on GuruFocus' analysis, OSE Immunotherapeutics (ORPOF) is currently considered Significantly Overvalued. The stock's GF Value™ is $3.31, compared to a current price of $4.43 — trading 33.8% above its estimated fair value. The current EV-to-EBITDA is -2.78. OSE Immunotherapeutics' overall GF Score™ is 51/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBITDA calculated?
EV-to-EBITDA is calculated from a company's financial statements. For OSE Immunotherapeutics (ORPOF), the current EV-to-EBITDA is -2.78 as of Jul. 22, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is OSE Immunotherapeutics (ORPOF) Overvalued in 2026?
Based on GuruFocus' analysis, OSE Immunotherapeutics stock appears to be overvalued.
The current stock price of $4.43 is trading 33.8% above its estimated GF Value™ of $3.31.
GuruFocus considers OSE Immunotherapeutics to be Significantly Overvalued.
Key valuation signals for ORPOF:
EV-to-EBITDA: -2.78
GF Value™: $3.31 vs. price of $4.43 (33.8% above fair value)
No single metric tells the full story. See the ORPOF stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
OSE Immunotherapeutics SA is a France-based biotechnology company focused on the development of immunotherapies for immune activation and regulation in the fields of immuno-oncology and autoimmune diseases. The product portfolio of the company comprises Tedopi, OSE-172, OSE-703, FR104 and OSE-127.
51GF Score
Get the complete analysis for ORPOF
EV-to-EBITDA is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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