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OSE ImmunotherapeuticsORPOF 51 3-Year Share Buyback Ratio is -6.70 as of Dec. 2025. GuruFocus rates ORPOF with a GF Score™ of 51/100 and a GF Value™ of $3.27 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,195 Biotechnology companies, OSE Immunotherapeutics ranks better than 61.59% on this metric.
Shares Outstanding (EOP) are shares that have been authorized, issued, and purchased by investors and are held by them.
3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. A positive ratio may indicate share buybacks over the period, while a zero or negative ratio may reflect no repurchases or potential share issuance. OSE Immunotherapeutics's current 3-Year Share Buyback Ratio was -6.70%.
The historical rank and industry rank for OSE Immunotherapeutics's 3-Year Share Buyback Ratio or its related term are showing as below:
ORPOF'
s 3-Year Share Buyback Ratio Range Over the Past 10 Years
Min: -21.7 Med: -7.5 Max: -1.4
Current: -6.7
During the past 13 years, OSE Immunotherapeutics's highest 3-Year Share Buyback Ratio was -1.40%. The lowest was -21.70%. And the median was -7.50%.
ORPOF's 3-Year Share Buyback Ratio is ranked better than 61.59% of 1195
companies
in the Biotechnology industry
Industry Median: -11.7
vs ORPOF: -6.70
OSE Immunotherapeutics (OTCPK:ORPOF) 3-Year Share Buyback Ratio Explanation
A negative number means the company might be issuing new shares. A positive number indicates that the company is buying back shares.
Be Aware
Investors usually like share buybacks. But as pointed by Warren Buffett, only if a company buys back shares at the prices below the stock's intrinsic value, it rewards remaining shareholders. If a company buys its overvalued stocks back, it destroys shareholder value.
OSE Immunotherapeutics 3-Year Share Buyback Ratio Related Terms
ORPOF vs VRTX, REGN, RVMD: 3-Year Share Buyback Ratio Comparison
For the Biotechnology subindustry, OSE Immunotherapeutics's 3-Year Share Buyback Ratio, along with its competitors' market caps and 3-Year Share Buyback Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
OSE Immunotherapeutics 3-Year Share Buyback Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, OSE Immunotherapeutics's 3-Year Share Buyback Ratio distribution charts can be found below:
* The bar in red indicates where OSE Immunotherapeutics's 3-Year Share Buyback Ratio falls into.
OSE Immunotherapeutics 3-Year Share Buyback Ratio Calculation
This is the annualized percentage change in shares outstanding from three years ago to the current year. The annualized percentage change is calculated with expontential compound based on the latest four years of annual data on Shares Outstanding (EOP).
Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average dividends per share growth rate.
What does a 3-Year Share Buyback Ratio of -6.70 mean?
OSE Immunotherapeutics (ORPOF) has a 3-Year Share Buyback Ratio of -6.70 as of Dec. 2025. The 3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. View historical data for OSE Immunotherapeutics and its competitors. According to the industry distribution chart, OSE Immunotherapeutics ranks #459 out of 1195 companies in the Biotechnology industry, placing it in the top 38.4%.
Is OSE Immunotherapeutics' 3-Year Share Buyback Ratio too high?
OSE Immunotherapeutics' current 3-Year Share Buyback Ratio is -6.70. Based on the distribution chart, OSE Immunotherapeutics ranks #459 out of 1195 companies in the Biotechnology industry, which is above the industry midpoint. Overall, OSE Immunotherapeutics has a GF Score™ of 51/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OSE Immunotherapeutics' 3-Year Share Buyback Ratio compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, OSE Immunotherapeutics ranks #459 out of 1195 companies for 3-Year Share Buyback Ratio. This puts OSE Immunotherapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year Share Buyback Ratio for a Biotechnology company?
A good 3-Year Share Buyback Ratio depends on the Biotechnology industry context. However, 3-Year Share Buyback Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year Share Buyback Ratio mean?
A high 3-Year Share Buyback Ratio can signal that a stock is expensive relative to its fundamentals. The 3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. View historical data for OSE Immunotherapeutics and its competitors. OSE Immunotherapeutics's current 3-Year Share Buyback Ratio is -6.70. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OSE Immunotherapeutics stock overvalued right now?
Based on GuruFocus' analysis, OSE Immunotherapeutics (ORPOF) is currently considered Significantly Overvalued. The stock's GF Value™ is $3.27, compared to a current price of $4.43 — trading 35.5% above its estimated fair value. The current 3-Year Share Buyback Ratio is -6.70. OSE Immunotherapeutics' overall GF Score™ is 51/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year Share Buyback Ratio calculated?
3-Year Share Buyback Ratio is calculated from a company's financial statements. For OSE Immunotherapeutics (ORPOF), the current 3-Year Share Buyback Ratio is -6.70 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is OSE Immunotherapeutics (ORPOF) Overvalued in 2026?
Based on GuruFocus' analysis, OSE Immunotherapeutics stock appears to be overvalued.
The current stock price of $4.43 is trading 35.5% above its estimated GF Value™ of $3.27.
GuruFocus considers OSE Immunotherapeutics to be Significantly Overvalued.
Key valuation signals for ORPOF:
3-Year Share Buyback Ratio: -6.70
GF Value™: $3.27 vs. price of $4.43 (35.5% above fair value)
No single metric tells the full story. See the ORPOF stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
OSE Immunotherapeutics SA is a France-based biotechnology company focused on the development of immunotherapies for immune activation and regulation in the fields of immuno-oncology and autoimmune diseases. The product portfolio of the company comprises Tedopi, OSE-172, OSE-703, FR104 and OSE-127.
51GF Score
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3-Year Share Buyback Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
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