ORPOF (OSE Immunotherapeutics) Shareholder Yield % : 10.71% (As of Dec. 2025)


ORPOF OSE Immunotherapeutics SA ORPOF
32 GF Score
Price $4.43
GF Value $2.10
Valuation Significantly Overvalued
! 6 Warning Signs
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What is OSE Immunotherapeutics Shareholder Yield %?

OSE Immunotherapeutics ORPOF 32 Shareholder Yield % is 10.71% as of Dec. 2025. GuruFocus rates ORPOF with a GF Score™ of 32/100 and a GF Value™ of $2.10 (Significantly Overvalued). The stock has 6 warning signs investors should review. Among 1,300 Biotechnology companies, OSE Immunotherapeutics ranks better than 94.46% on this metric.

Shareholder Yield % is how much money shareholders receive from a company that is in the form of cash dividends, net stock repurchases, and debt reduction. It is a measure of shareholder return. As of today, OSE Immunotherapeutics's Shareholder Yield % was 10.71%.


OSE Immunotherapeutics  (OTCPK:ORPOF) Shareholder Yield % Explanation

Shareholder Yield % is how much money shareholders receive from a company that is in the form of cash dividends, net stock repurchases, and debt reduction. The term was coined by William W. Priest of Epoch Investment Partners in a paper in 2005 entitled The Case for Shareholder Yield as a Dominant Driver of Future Equity Returns. William Priest indicated that "shareholder yield is a term that we came up with to reflect the various ways dividends can be paid to owners of a business in a publicly-traded company."

Shareholder Yield % is calculated by three components: Dividend Yield %, Buyback Yield %, and Net Debt Paydown Yield %.

Dividend Yield % shows how much a company pays out in dividends each year relative to its stock price, which is most obvious form of shareholder return.

Buyback Yield % is the net repurchase of shares outstanding over the market capital of the company. Shares repurchases also increase shareholder value by returning the money back to shareholders.

Net Debt Paydown Yield % is the change in average of four quarters of company's total debt over a company's market cap. Assuming the total value of a company remains that same, shareholder value is increased as debt is reduced.


OSE Immunotherapeutics Shareholder Yield % Related Terms


OSE Immunotherapeutics Shareholder Yield % Historical Data

* Premium members only.

The historical data trend for OSE Immunotherapeutics's Shareholder Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

OSE Immunotherapeutics Shareholder Yield % Chart

OSE Immunotherapeutics Annual Data
Trend Dec16 Dec17 Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Shareholder Yield %
Get a 7-Day Free Trial Premium Member Only Premium Member Only -4.27 -9.13 -18.05 -1.52 6.86

OSE Immunotherapeutics Semi-Annual Data
Jun16 Dec16 Jun17 Dec17 Jun18 Dec18 Jun19 Dec19 Jun20 Dec20 Jun21 Dec21 Jun22 Dec22 Jun23 Dec23 Jun24 Dec24 Jun25 Dec25
Shareholder Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -18.05 -10.88 -1.52 1.31 6.86

ORPOF vs VRTX, REGN, ALNY: Shareholder Yield % Comparison

For the Biotechnology subindustry, OSE Immunotherapeutics's Shareholder Yield %, along with its competitors' market caps and Shareholder Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


OSE Immunotherapeutics Shareholder Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, OSE Immunotherapeutics's Shareholder Yield % distribution charts can be found below:

* The bar in red indicates where OSE Immunotherapeutics's Shareholder Yield % falls into.


ORPOF
32GF Score
OSE Immunotherapeutics SA ORPOF
Shareholder Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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OSE Immunotherapeutics Shareholder Yield % Calculation

OSE Immunotherapeutics's Shareholder Yield % for the quarter that ended in Dec. 2025 is calculated as:

Shareholder Yield %=Dividend Yield %+Buyback Yield %+Net Debt Paydown Yield %
=0.00 %+-0.06 %+1.83 %
=1.77 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

* All the data are calculated by TTM values. Note that if a companies is traded in several exchanges, then we calculate the company level data for Shareholder Yield % using the primary share class stock data. The calculation result in definition page is for demonstration purpose only, and it's showing the share class level data. Therefore, the numbers in the calculation may differ from elsewhere if the stock is not a primary share.

Frequently Asked Questions Learn more about Shareholder Yield % →
What does a Shareholder Yield % of 10.71% mean?
OSE Immunotherapeutics (ORPOF) has a Shareholder Yield % of 10.71% as of Dec. 2025. Shareholder Yield is how much money shareholders receive from a company that is in the form of cash dividends, net stock repurchases, and debt reduction. View historical data on OSE Immunotherapeutics and its competitors. According to the industry distribution chart, OSE Immunotherapeutics ranks #72 out of 1300 companies in the Biotechnology industry, placing it in the top 5.5%.
Is OSE Immunotherapeutics' Shareholder Yield % too high?
OSE Immunotherapeutics' current Shareholder Yield % is 10.71%. Based on the distribution chart, OSE Immunotherapeutics ranks #72 out of 1300 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, OSE Immunotherapeutics has a GF Score™ of 32/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does OSE Immunotherapeutics' Shareholder Yield % compare to VRTX and REGN?
According to the Biotechnology industry distribution chart, OSE Immunotherapeutics ranks #72 out of 1300 companies for Shareholder Yield %. This places OSE Immunotherapeutics in the top 6% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Shareholder Yield % for a Biotechnology company?
A good Shareholder Yield % depends on the Biotechnology industry context. However, Shareholder Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Shareholder Yield % mean?
A high Shareholder Yield % can signal that a stock is expensive relative to its fundamentals. Shareholder Yield is how much money shareholders receive from a company that is in the form of cash dividends, net stock repurchases, and debt reduction. View historical data on OSE Immunotherapeutics and its competitors. OSE Immunotherapeutics's current Shareholder Yield % is 10.71%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is OSE Immunotherapeutics stock overvalued right now?
Based on GuruFocus' analysis, OSE Immunotherapeutics (ORPOF) is currently considered Significantly Overvalued. The stock's GF Value™ is $2.10, compared to a current price of $4.43 — trading 111% above its estimated fair value. The current Shareholder Yield % is 10.71%. OSE Immunotherapeutics' overall GF Score™ is 32/100 with 6 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Shareholder Yield % calculated?
Shareholder Yield % is calculated from a company's financial statements. For OSE Immunotherapeutics (ORPOF), the current Shareholder Yield % is 10.71% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is OSE Immunotherapeutics (ORPOF) Overvalued in 2026?

Based on GuruFocus' analysis, OSE Immunotherapeutics stock appears to be overvalued. The current stock price of $4.43 is trading 111% above its estimated GF Value™ of $2.10. GuruFocus considers OSE Immunotherapeutics to be Significantly Overvalued.

Key valuation signals for ORPOF:

  • Shareholder Yield %: 10.71%
  • GF Value™: $2.10 vs. price of $4.43 (111% above fair value)
  • GF Score™: 32/100 with 6 warning signs

No single metric tells the full story. See the ORPOF stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


OSE Immunotherapeutics Business Description

Address 22, Boulevard Benoni Goullin, Nantes, FRA, 44200
OSE Immunotherapeutics SA is a France-based biotechnology company focused on the development of immunotherapies for immune activation and regulation in the fields of immuno-oncology and autoimmune diseases. The product portfolio of the company comprises Tedopi, OSE-172, OSE-703, FR104 and OSE-127.
32GF Score

Get the complete analysis for ORPOF

Shareholder Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$4.43
Price
$2.10
GF Value