ICU (SeaStar Medical Holding) Operating Margin %: -727.88% (As of Mar. 2026)


ICU SeaStar Medical Holding Corp ICU
29 GF Score
Price $2.98
! 4 Warning Signs
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What is SeaStar Medical Holding Operating Margin %?

SeaStar Medical Holding ICU 29 Operating Margin % is -727.88% as of Mar. 2026. GuruFocus rates ICU with a GF Score™ of 29/100. The stock has 4 warning signs investors should review. Among 944 Biotechnology companies, SeaStar Medical Holding ranks worse than 76.69% on this metric.

Operating Margin % is calculated as Operating Income divided by its Revenue. SeaStar Medical Holding's Operating Income for the three months ended in Mar. 2026 was $-3.60 Mil. SeaStar Medical Holding's Revenue for the three months ended in Mar. 2026 was $0.50 Mil. Therefore, SeaStar Medical Holding's Operating Margin % for the quarter that ended in Mar. 2026 was -727.88%.

The historical rank and industry rank for SeaStar Medical Holding's Operating Margin % or its related term are showing as below:

ICU' s Operating Margin % Range Over the Past 10 Years
Min: -13216.3   Med: -7101.47   Max: -832.45
Current: -832.45


ICU's Operating Margin % is ranked worse than
76.69% of 944 companies
in the Biotechnology industry
Industry Median: -86.83 vs ICU: -832.45

SeaStar Medical Holding's 5-Year Average Operating Margin % Growth Rate was 0.00% per year.

SeaStar Medical Holding's Operating Income for the three months ended in Mar. 2026 was $-3.60 Mil. Its Operating Income for the trailing twelve months (TTM) ended in Mar. 2026 was $-11.95 Mil.


SeaStar Medical Holding  (NAS:ICU) Operating Margin % Explanation

Just like Gross Margin %, it is important to see a company maintains its operating margin over time. Among the same industry, a company with higher operating margin is more efficient in its operation. It is also more stable during industry slowdown or recessions. Peter Lynch prefers those with higher margins than those with lower margins.


Be Aware

Operating Margin % can be manipulated by adjusting the rate of depreciation, depletion and amortization (DDA).

If a company is facing competition, its Operating Margin % may decline. Often the Operating Margin % declines well before the company's Revenue or even profit decline. Therefore, Operating Margin % is a very important indicator of whether the company is facing problems.

For instance, by 2012, Nokia (NOK)'s problems were well known and its stock had lost more than 90% of its market value since 2007. But Nokia’s Operating Margin % had already been in decline since 2002, although its Earnings per Share (Diluted) were still rising. Investors who paid attention to Operating Margin % would have avoided this huge loss. The same can be said for Research-in-Motion (RIMM).

Therefore, Operating Margin % is a very important screening filter for GuruFocus. GuruFocus's Buffett-Munger screener requires that the profit margin is either consistent or expanding. The Model Portfolio of the Buffett-Munger screener has outperformed the market every year since inception in 2009.


SeaStar Medical Holding Operating Margin % Related Terms


SeaStar Medical Holding Operating Margin % Historical Data

* Premium members only.

The historical data trend for SeaStar Medical Holding's Operating Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

SeaStar Medical Holding Operating Margin % Chart

SeaStar Medical Holding Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Operating Margin %
Get a 7-Day Free Trial 0.00 0.00 0.00 -13,216.30 -986.63

SeaStar Medical Holding Quarterly Data
Mar21 Jun21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Operating Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -1,304.44 -519.53 -1,955.74 -718.10 -727.88

ICU vs MBRX, LEXX, INTI: Operating Margin % Comparison

For the Biotechnology subindustry, SeaStar Medical Holding's Operating Margin %, along with its competitors' market caps and Operating Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


SeaStar Medical Holding Operating Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, SeaStar Medical Holding's Operating Margin % distribution charts can be found below:

* The bar in red indicates where SeaStar Medical Holding's Operating Margin % falls into.


ICU
29GF Score
SeaStar Medical Holding Corp ICU
Operating Margin % is just one metric. See GF Score™, valuation, warning signs, and more.
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SeaStar Medical Holding Operating Margin % Calculation

Operating Margin % - also known as operating income margin, operating profit margin and return on sales (ROS) - is the ratio of Operating Income divided by net sales or Revenue, usually presented in percent.

SeaStar Medical Holding's Operating Margin % for the fiscal year that ended in Dec. 2025 is calculated as

Operating Margin %=Operating Income (A: Dec. 2025 ) / Revenue (A: Dec. 2025 )
=-12.175 / 1.234
=-986.63 %

SeaStar Medical Holding's Operating Margin % for the quarter that ended in Mar. 2026 is calculated as

Operating Margin %=Operating Income (Q: Mar. 2026 ) / Revenue (Q: Mar. 2026 )
=-3.603 / 0.495
=-727.88 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Operating Margin % →
What does a Operating Margin % of -727.88% mean?
SeaStar Medical Holding (ICU) has a Operating Margin % of -727.88% as of Mar. 2026. Operating margin is the ratio of total operating income to net sales. View historical data on SeaStar Medical Holding and its competitors. According to the industry distribution chart, SeaStar Medical Holding ranks #724 out of 944 companies in the Biotechnology industry, placing it in the top 76.7%.
Is SeaStar Medical Holding's Operating Margin % too high?
SeaStar Medical Holding's current Operating Margin % is -727.88%. Based on the distribution chart, SeaStar Medical Holding ranks #724 out of 944 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, SeaStar Medical Holding has a GF Score™ of 29/100, reflecting its overall financial health beyond just this single metric.
How does SeaStar Medical Holding's Operating Margin % compare to MBRX and LEXX?
According to the Biotechnology industry distribution chart, SeaStar Medical Holding ranks #724 out of 944 companies for Operating Margin %. This places SeaStar Medical Holding in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Operating Margin % for a Biotechnology company?
A good Operating Margin % depends on the Biotechnology industry context. However, Operating Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Operating Margin % mean?
A high Operating Margin % can signal that a stock is expensive relative to its fundamentals. Operating margin is the ratio of total operating income to net sales. View historical data on SeaStar Medical Holding and its competitors. SeaStar Medical Holding's current Operating Margin % is -727.88%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is SeaStar Medical Holding stock overvalued right now?
SeaStar Medical Holding (ICU) has a current Operating Margin % of -727.88%. The current Operating Margin % is -727.88%. SeaStar Medical Holding's overall GF Score™ is 29/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Operating Margin % calculated?
Operating Margin % is calculated from a company's financial statements. For SeaStar Medical Holding (ICU), the current Operating Margin % is -727.88% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

SeaStar Medical Holding Business Description

Address 3513 Brighton Boulevard, Suite 410, Denver, CO, USA, 80216
SeaStar Medical Holding Corp is a medical technology company developing proprietary solutions to reduce the consequences of hyperinflammation on vital organs. It is developing and commercializing extracorporeal therapies that target the effector cells that drive systemic inflammation, causing direct tissue damage and secreting a range of pro-inflammatory cytokines that initiate and propagate imbalanced immune responses. The Company is comprised of a single reportable segment, which is its Device Segment.
29GF Score

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Operating Margin % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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