Tiziana Life SciencesTLSA -7.63%28 Return-on-Tangible-Asset is -182.24% as of Dec. 2025. GuruFocus rates TLSA with a GF Score™ of 28/100. The stock has 2 warning signs investors should review. Among 1,413 Biotechnology companies, Tiziana Life Sciences ranks worse than 86.27% on this metric.
Return-on-Tangible-Asset is calculated as Net Income divided by its average total tangible assets. Total tangible assets equals to Total Assets minus Intangible Assets. Tiziana Life Sciences's annualizedNet Income for the quarter that ended in Dec. 2025 was $-25.60 Mil. Tiziana Life Sciences's average total tangible assets for the quarter that ended in Dec. 2025 was $14.05 Mil. Therefore, Tiziana Life Sciences's annualized Return-on-Tangible-Asset for the quarter that ended in Dec. 2025 was -182.24%.
The historical rank and industry rank for Tiziana Life Sciences's Return-on-Tangible-Asset or its related term are showing as below:
TLSA'
s Return-on-Tangible-Asset Range Over the Past 10 Years
Min: -201.17 Med: -99.56 Max: -39.24
Current: -140.42
During the past 13 years, Tiziana Life Sciences's highest Return-on-Tangible-Asset was -39.24%. The lowest was -201.17%. And the median was -99.56%.
TLSA's Return-on-Tangible-Asset is ranked worse than 86.27% of 1413
companies
in the Biotechnology industry
Industry Median: -35.75
vs TLSA: -140.42
Tiziana Life Sciences (NAS:TLSA) Return-on-Tangible-Asset Explanation
Return-on-Tangible-Asset measures the rate of return on the average total tangible assets (total assets minus intangible assets). Tangible means physical in nature. Intangible Assets are assets that are not physical in nature, and typically "derive their value from legal or intellectual rights." Return-on-Tangible-Asset measures a firm's efficiency at generating profits from its tangible assets. It shows how well a company uses what it has to generate earnings. Return-on-Tangible-Assets can vary drastically across industries. Therefore, Return-on-Tangible-Asset should not be used to compare companies in different industries.
Be Aware
Like ROE and ROA, Return-on-Tangible-Asset is calculated with only 12 months data. Fluctuations in the companys earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. Return-on-Tangible-Asset can be affected by events such as stock buyback or issuance, and by a companys tax rate and its interest payment. Return-on-Tangible-Asset may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).
Many analysts argue the higher return the better. Buffett states that really high Return-on-Tangible-Asset may indicate vulnerability in the durability of the competitive advantage.
Tiziana Life Sciences Return-on-Tangible-Asset Related Terms
Tiziana Life Sciences Return-on-Tangible-Asset Historical Data
* Premium members only.
The historical data trend for Tiziana Life Sciences's Return-on-Tangible-Asset can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Tiziana Life Sciences Return-on-Tangible-Asset Chart
TLSA vs SPRB, MIST, TNYA: Return-on-Tangible-Asset Comparison
For the Biotechnology subindustry, Tiziana Life Sciences's Return-on-Tangible-Asset, along with its competitors' market caps and Return-on-Tangible-Asset data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Tiziana Life Sciences Return-on-Tangible-Asset vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Tiziana Life Sciences's Return-on-Tangible-Asset distribution charts can be found below:
* The bar in red indicates where Tiziana Life Sciences's Return-on-Tangible-Asset falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Asset, the net income of the last fiscal year and the average total tangible assets over the fiscal year are used. In calculating the quarterly data,
the Net Income data used here is two times the semi-annual (Dec. 2025) net income data.
What does a Return-on-Tangible-Asset of -182.24% mean?
Tiziana Life Sciences (TLSA) has a Return-on-Tangible-Asset of -182.24% as of Dec. 2025. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Tiziana Life Sciences and its competitors. According to the industry distribution chart, Tiziana Life Sciences ranks #1219 out of 1413 companies in the Biotechnology industry, placing it in the top 86.3%.
Is Tiziana Life Sciences' Return-on-Tangible-Asset too high?
Tiziana Life Sciences' current Return-on-Tangible-Asset is -182.24%. Based on the distribution chart, Tiziana Life Sciences ranks #1219 out of 1413 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Tiziana Life Sciences has a GF Score™ of 28/100, reflecting its overall financial health beyond just this single metric.
How does Tiziana Life Sciences' Return-on-Tangible-Asset compare to SPRB and MIST?
According to the Biotechnology industry distribution chart, Tiziana Life Sciences ranks #1219 out of 1413 companies for Return-on-Tangible-Asset. This places Tiziana Life Sciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Asset for a Biotechnology company?
A good Return-on-Tangible-Asset depends on the Biotechnology industry context. However, Return-on-Tangible-Asset should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Asset mean?
A high Return-on-Tangible-Asset can signal that a stock is expensive relative to its fundamentals. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Tiziana Life Sciences and its competitors. Tiziana Life Sciences's current Return-on-Tangible-Asset is -182.24%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Tiziana Life Sciences stock overvalued right now?
Tiziana Life Sciences (TLSA) has a current Return-on-Tangible-Asset of -182.24%. The current Return-on-Tangible-Asset is -182.24%. Tiziana Life Sciences' overall GF Score™ is 28/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Asset calculated?
Return-on-Tangible-Asset is calculated from a company's financial statements. For Tiziana Life Sciences (TLSA), the current Return-on-Tangible-Asset is -182.24% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Tiziana Life Sciences Ltd is a clinical-stage biotechnology company that specializes in developing transformative therapies for neurodegenerative and neuroinflammatory diseases. The company's clinical pipeline includes drug assets for Non-Active Secondary Progressive Multiple Sclerosis, Multiple System Atrophy, Alzheimer's, and Amyotrophic Lateral Sclerosis. The company's mission is to design and deliver next-generation immunotherapies for neurodegenerative and neuroinflammatory diseases. The company's main immunotherapeutic candidate, Foralumab (TZLS-401), is being developed for Non-Active Secondary Progressive Multiple Sclerosis, Alzheimer's, and other CNS indications.
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