Tiziana Life SciencesTLSA +2.93%30 Return-on-Tangible-Equity is -553.35% as of Dec. 2025. GuruFocus rates TLSA with a GF Score™ of 30/100. The stock has 2 warning signs investors should review. Among 1,201 Biotechnology companies, Tiziana Life Sciences ranks worse than 94% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Tiziana Life Sciences's annualized net income for the quarter that ended in Dec. 2025 was $-25.60 Mil. Tiziana Life Sciences's average shareholder tangible equity for the quarter that ended in Dec. 2025 was $4.63 Mil. Therefore, Tiziana Life Sciences's annualized Return-on-Tangible-Equity for the quarter that ended in Dec. 2025 was -553.35%.
The historical rank and industry rank for Tiziana Life Sciences's Return-on-Tangible-Equity or its related term are showing as below:
TLSA'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -946.89 Med: -129.01 Max: -45.23
Current: -419.27
During the past 13 years, Tiziana Life Sciences's highest Return-on-Tangible-Equity was -45.23%. The lowest was -946.89%. And the median was -129.01%.
TLSA's Return-on-Tangible-Equity is ranked worse than 94% of 1201
companies
in the Biotechnology industry
Industry Median: -42.4
vs TLSA: -419.27
Tiziana Life Sciences (NAS:TLSA) Return-on-Tangible-Equity Explanation
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Tiziana Life Sciences Return-on-Tangible-Equity Related Terms
Tiziana Life Sciences Return-on-Tangible-Equity Historical Data
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The historical data trend for Tiziana Life Sciences's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Tiziana Life Sciences Return-on-Tangible-Equity Chart
TLSA vs SPRB, MIST, TNYA: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Tiziana Life Sciences's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Tiziana Life Sciences Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Tiziana Life Sciences's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Tiziana Life Sciences's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is two times the semi-annual (Dec. 2025) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -553.35% mean?
Tiziana Life Sciences (TLSA) has a Return-on-Tangible-Equity of -553.35% as of Dec. 2025. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Tiziana Life Sciences and its competitors. According to the industry distribution chart, Tiziana Life Sciences ranks #1129 out of 1201 companies in the Biotechnology industry, placing it in the top 94%.
Is Tiziana Life Sciences' Return-on-Tangible-Equity too high?
Tiziana Life Sciences' current Return-on-Tangible-Equity is -553.35%. Based on the distribution chart, Tiziana Life Sciences ranks #1129 out of 1201 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Tiziana Life Sciences has a GF Score™ of 30/100, reflecting its overall financial health beyond just this single metric.
How does Tiziana Life Sciences' Return-on-Tangible-Equity compare to SPRB and MIST?
According to the Biotechnology industry distribution chart, Tiziana Life Sciences ranks #1129 out of 1201 companies for Return-on-Tangible-Equity. This places Tiziana Life Sciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Tiziana Life Sciences and its competitors. Tiziana Life Sciences's current Return-on-Tangible-Equity is -553.35%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Tiziana Life Sciences stock overvalued right now?
Tiziana Life Sciences (TLSA) has a current Return-on-Tangible-Equity of -553.35%. The current Return-on-Tangible-Equity is -553.35%. Tiziana Life Sciences' overall GF Score™ is 30/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Tiziana Life Sciences (TLSA), the current Return-on-Tangible-Equity is -553.35% as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Tiziana Life Sciences Ltd is a clinical-stage biotechnology company that specializes in developing transformative therapies for neurodegenerative and neuroinflammatory diseases. The company's clinical pipeline includes drug assets for Non-Active Secondary Progressive Multiple Sclerosis, Multiple System Atrophy, Alzheimer's, and Amyotrophic Lateral Sclerosis. The company's mission is to design and deliver next-generation immunotherapies for neurodegenerative and neuroinflammatory diseases. The company's main immunotherapeutic candidate, Foralumab (TZLS-401), is being developed for Non-Active Secondary Progressive Multiple Sclerosis, Alzheimer's, and other CNS indications.
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