PRME (Prime Medicine) Accumulated Depreciation: $-22.29 Mil (As of Mar. 2026)

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PRME Prime Medicine Inc PRME
25 GF Score
Price $2.92
! 4 Warning Signs
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What is Prime Medicine Accumulated Depreciation?

Prime Medicine PRME -3.15% 25 Accumulated Depreciation is $-22.29 Mil as of Mar. 2026. GuruFocus rates PRME with a GF Score™ of 25/100. The stock has 4 warning signs investors should review.

Note: A negative number here means the assets are depreciated. When depricates more, the absolute value gets bigger.

Prime Medicine's quarterly accumulated depreciation increased from Sep. 2025 ($-18.56 Mil) to Dec. 2025 ($-20.43 Mil) and increased from Dec. 2025 ($-20.43 Mil) to Mar. 2026 ($-22.29 Mil).

Prime Medicine's annual accumulated depreciation increased from Dec. 2023 ($-7.48 Mil) to Dec. 2024 ($-13.60 Mil) and increased from Dec. 2024 ($-13.60 Mil) to Dec. 2025 ($-20.43 Mil).

Prime Medicine Accumulated Depreciation Related Terms

Prime Medicine Accumulated Depreciation Historical Data

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The historical data trend for Prime Medicine's Accumulated Depreciation can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Prime Medicine Accumulated Depreciation Chart

Prime Medicine Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Accumulated Depreciation
Get a 7-Day Free Trial -0.61 -2.83 -7.48 -13.60 -20.43

Prime Medicine Quarterly Data
Dec20 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Accumulated Depreciation Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -15.30 -16.68 -18.56 -20.43 -22.29
PRME
25GF Score
Prime Medicine Inc PRME
Accumulated Depreciation is just one metric. See GF Score™, valuation, warning signs, and more.
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Prime Medicine Accumulated Depreciation Calculation

The cumulative depreciation of an asset up to a single point in its life. Regardless of the method used to calculate it, the depreciation of an asset during a single period is added to the previous period's accumulated depreciation to get the current accumulated depreciation.

What does a Accumulated Depreciation of $-22.29 Mil mean?
Prime Medicine (PRME) has a Accumulated Depreciation of $-22.29 Mil as of Mar. 2026. Accumulated depreciation is a contra-asset item that accounts for the decline in value of long-term assets. View historical data on Prime Medicine and its competitors.
Is Prime Medicine's Accumulated Depreciation too high?
Prime Medicine's current Accumulated Depreciation is $-22.29 Mil. Overall, Prime Medicine has a GF Score™ of 25/100, reflecting its overall financial health beyond just this single metric.
How does Prime Medicine's Accumulated Depreciation compare to VSTM and ALT?
Prime Medicine's Accumulated Depreciation of $-22.29 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Accumulated Depreciation for a Biotechnology company?
A good Accumulated Depreciation depends on the Biotechnology industry context. However, Accumulated Depreciation should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Accumulated Depreciation mean?
A high Accumulated Depreciation can signal that a stock is expensive relative to its fundamentals. Accumulated depreciation is a contra-asset item that accounts for the decline in value of long-term assets. View historical data on Prime Medicine and its competitors. Prime Medicine's current Accumulated Depreciation is $-22.29 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prime Medicine stock overvalued right now?
Prime Medicine (PRME) has a current Accumulated Depreciation of $-22.29 Mil. The current Accumulated Depreciation is $-22.29 Mil. Prime Medicine's overall GF Score™ is 25/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Accumulated Depreciation calculated?
Accumulated Depreciation is calculated from a company's financial statements. For Prime Medicine (PRME), the current Accumulated Depreciation is $-22.29 Mil as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Prime Medicine Business Description

Address 60 First Street, Cambridge, MA, USA, 02141
Prime Medicine Inc is a biotechnology company focused on developing a new class of genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its program, PM577 for Wilson Disease, is designed to initially correct the H1069Q mutation in the ATP7B gene and is supported by preclinical data showing targeted correction and restoration of copper homeostasis in animal models. In addition, PM647 is being developed for alpha-1 antitrypsin deficiency, or AATD, another liver targeted disease with substantial unmet need.
25GF Score

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