Think of Enterprise Value as the theoretical takeover price. It is more comprehensive than market capitalization (Market Cap), which only includes common equity. Enterprise Value is calculated as the market cap plus debt and minority interest and preferred shares, minus total cash, cash equivalents, and marketable securities.
EV-to-EBIT is calculated as Enterprise Value divided by its EBIT. As of today, Prime Medicine's Enterprise Value is $553.38 Mil.
Prime Medicine's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 was $-206.61 Mil. Therefore, Prime Medicine's EV-to-EBIT ratio for today is -2.68.
EV-to-EBITDA is calculated as Enterprise Value divided by its EBITDA. As of today, Prime Medicine's Enterprise Value is $553.38 Mil.
Prime Medicine's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 was $-199.14 Mil. Therefore, Prime Medicine's EV-to-EBITDA ratio for today is -2.78.
EV-to-Revenue is calculated as Enterprise Value divided by its Revenue. As of today, Prime Medicine's Enterprise Value is $553.38 Mil.
Prime Medicine's Revenue for the trailing twelve months (TTM) ended in Mar. 2026 was $4.03 Mil. Therefore, Prime Medicine's EV-to-Revenue ratio for today is 137.18.
EV-to-FCF is calculated as Enterprise Value divided by its Free Cash Flow. As of today, Prime Medicine's Enterprise Value is $553.38 Mil.
Prime Medicine's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 was $-158.74 Mil. Therefore, Prime Medicine's EV-to-FCF ratio for today is -3.49.
*** Please note that the current Enterprise Value is calculated using the current market capitalization and the most recently available financial data. If key financial fields—Long-Term Debt & Capital Lease Obligation and Short-Term Debt & Capital Lease Obligation—are recorded as null in the latest reporting period, our data vendor will default to using data from the prior period with valid entries.
Prime Medicine (NAS:PRME) Enterprise Value Explanation
When an investor buy a company, the investor needs to pay not only the common shares, he/she also needs to pay the shareholders of Preferred Stocks. He also assumes the debt of the company, and receives the cash on the company's balance sheet.
If a company has more cash than debt, the investor actually pays less than the Market Cap because he immediately owns the cash once the transaction goes through.
The market value of Preferred Stock needs to be added to the market value of common stocks in the calculation of Enterprise Value.
For the companies with the same Market Cap, the smaller the Enterprise Value is, the cheaper the company is.
Enterprise Value can be negative when the company's net cash is more than its Market Cap. In this case the investor is basically getting the company for free and get paid for that.
1. EV-to-EBIT is calculated as Enterprise Value divided by its EBIT.
Prime Medicine's current Enterprise Value is $553.38 Mil.
Prime Medicine's EBIT for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-206.61 Mil.
2. EV-to-EBITDA is calculated as Enterprise Value divided by its EBITDA.
Prime Medicine's current Enterprise Value is $553.38 Mil.
Prime Medicine's EBITDA for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-199.14 Mil.
Prime Medicine's current Enterprise Value is $553.38 Mil.
Prime Medicine's Revenue for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $4.03 Mil.
Prime Medicine's current Enterprise Value is $553.38 Mil.
Prime Medicine's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-156.42 Mil.
Prime Medicine's current Enterprise Value is $553.38 Mil.
Prime Medicine's Free Cash Flow for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-158.74 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Prime Medicine Enterprise Value Related Terms
Prime Medicine Enterprise Value Historical Data
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The historical data trend for Prime Medicine's Enterprise Value can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PRME vs IMMX, SGP, ACRS: Enterprise Value Comparison
For the Biotechnology subindustry, Prime Medicine's Enterprise Value, along with its competitors' market caps and Enterprise Value data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Prime Medicine Enterprise Value vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Prime Medicine's Enterprise Value distribution charts can be found below:
* The bar in red indicates where Prime Medicine's Enterprise Value falls into.
Enterprise Value is calculated as the market cap plus debt and minority interest and preferred shares, minus total cash, cash equivalents, and marketable securities.
Prime Medicine's Enterprise Value for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Prime Medicine (PRME) has a Enterprise Value of $553.38 Mil as of Jun. 25, 2026. Enterprise value equals the sum of market cap, debt and preferred shares less cash and equivalents. View historical data on Prime Medicine and its competitors.
Is Prime Medicine's Enterprise Value too high?
Prime Medicine's current Enterprise Value is $553.38 Mil. Overall, Prime Medicine has a GF Score™ of 25/100, reflecting its overall financial health beyond just this single metric.
How does Prime Medicine's Enterprise Value compare to IMMX and SGP?
Prime Medicine's Enterprise Value of $553.38 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Enterprise Value for a Biotechnology company?
A good Enterprise Value depends on the Biotechnology industry context. However, Enterprise Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Enterprise Value mean?
A high Enterprise Value can signal that a stock is expensive relative to its fundamentals. Enterprise value equals the sum of market cap, debt and preferred shares less cash and equivalents. View historical data on Prime Medicine and its competitors. Prime Medicine's current Enterprise Value is $553.38 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prime Medicine stock overvalued right now?
Prime Medicine (PRME) has a current Enterprise Value of $553.38 Mil. The current Enterprise Value is $553.38 Mil. Prime Medicine's overall GF Score™ is 25/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Enterprise Value calculated?
Enterprise Value is calculated from a company's financial statements. For Prime Medicine (PRME), the current Enterprise Value is $553.38 Mil as of Jun. 25, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Prime Medicine Inc is a biotechnology company focused on developing a new class of genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its program, PM577 for Wilson Disease, is designed to initially correct the H1069Q mutation in the ATP7B gene and is supported by preclinical data showing targeted correction and restoration of copper homeostasis in animal models. In addition, PM647 is being developed for alpha-1 antitrypsin deficiency, or AATD, another liver targeted disease with substantial unmet need.
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