PRME (Prime Medicine) OCF Margin %: -4,989.49% (As of Mar. 2026)


PRME Prime Medicine Inc PRME
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What is Prime Medicine OCF Margin %?

Prime Medicine PRME +2.09% 25 OCF Margin % is -4,989.49% as of Mar. 2026. GuruFocus rates PRME with a GF Score™ of 25/100. The stock has 4 warning signs investors should review. Among 960 Biotechnology companies, Prime Medicine ranks worse than 88.65% on this metric.

OCF Margin % is calculated as Cash Flow from Operations divided by its Revenue. Prime Medicine's Cash Flow from Operations for the three months ended in Mar. 2026 was $-42.71 Mil. Prime Medicine's Revenue for the three months ended in Mar. 2026 was $0.86 Mil. Therefore, Prime Medicine's OCF Margin % for the quarter that ended in Mar. 2026 was -4,989.49%.

As of today, Prime Medicine's current OCF Yield % is -27.23%.

The historical rank and industry rank for Prime Medicine's OCF Margin % or its related term are showing as below:

PRME' s OCF Margin % Range Over the Past 10 Years
Min: -4118.84   Med: -3509.59   Max: -106.41
Current: -3877.47

During the past 6 years, the highest OCF Margin % of Prime Medicine was -106.41%. The lowest was -4118.84%. And the median was -3509.59%.

PRME's OCF Margin % is ranked worse than
88.65% of 960 companies
in the Biotechnology industry
Industry Median: -68.59 vs PRME: -3877.47

Prime Medicine OCF Margin % Related Terms

Prime Medicine OCF Margin % Historical Data

* Premium members only.

The historical data trend for Prime Medicine's OCF Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Prime Medicine OCF Margin % Chart

Prime Medicine Annual Data
Trend Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
OCF Margin %
Get a 7-Day Free Trial 0.00 0.00 0.00 -4,118.84 -3,509.59

Prime Medicine Quarterly Data
Dec20 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
OCF Margin % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -3,360.18 -3,714.08 -2,860.33 -4,445.82 -4,989.49

PRME vs IMMX, SGP, ACRS: OCF Margin % Comparison

For the Biotechnology subindustry, Prime Medicine's OCF Margin %, along with its competitors' market caps and OCF Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Prime Medicine OCF Margin % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Prime Medicine's OCF Margin % distribution charts can be found below:

* The bar in red indicates where Prime Medicine's OCF Margin % falls into.


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Prime Medicine Inc PRME
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Prime Medicine OCF Margin % Calculation

OCF Margin % is the ratio of Cash Flow from Operations divided by net sales or Revenue, usually presented in percent.

Prime Medicine's OCF Margin for the fiscal year that ended in Dec. 2025 is calculated as

OCF Margin=Cash Flow from Operations (A: Dec. 2025 )/Revenue (A: Dec. 2025 )
=-162.564/4.632
=-3,509.59 %

Prime Medicine's OCF Margin for the quarter that ended in Mar. 2026 is calculated as

OCF Margin=Cash Flow from Operations (Q: Mar. 2026 )/Revenue (Q: Mar. 2026 )
=-42.71/0.856
=-4,989.49 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about OCF Margin % →
What does a OCF Margin % of -4,989.49% mean?
Prime Medicine (PRME) has a OCF Margin % of -4,989.49% as of Mar. 2026. OCF Margin is the ratio of Cash Flow from Operations to Total Revenue. View historical data on Prime Medicine and its competitors. According to the industry distribution chart, Prime Medicine ranks #851 out of 960 companies in the Biotechnology industry, placing it in the top 88.6%.
Is Prime Medicine's OCF Margin % too high?
Prime Medicine's current OCF Margin % is -4,989.49%. Based on the distribution chart, Prime Medicine ranks #851 out of 960 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Prime Medicine has a GF Score™ of 25/100, reflecting its overall financial health beyond just this single metric.
How does Prime Medicine's OCF Margin % compare to IMMX and SGP?
According to the Biotechnology industry distribution chart, Prime Medicine ranks #851 out of 960 companies for OCF Margin %. This places Prime Medicine in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good OCF Margin % for a Biotechnology company?
A good OCF Margin % depends on the Biotechnology industry context. However, OCF Margin % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high OCF Margin % mean?
A high OCF Margin % can signal that a stock is expensive relative to its fundamentals. OCF Margin is the ratio of Cash Flow from Operations to Total Revenue. View historical data on Prime Medicine and its competitors. Prime Medicine's current OCF Margin % is -4,989.49%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prime Medicine stock overvalued right now?
Prime Medicine (PRME) has a current OCF Margin % of -4,989.49%. The current OCF Margin % is -4,989.49%. Prime Medicine's overall GF Score™ is 25/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is OCF Margin % calculated?
OCF Margin % is calculated from a company's financial statements. For Prime Medicine (PRME), the current OCF Margin % is -4,989.49% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Prime Medicine Business Description

Address 60 First Street, Cambridge, MA, USA, 02141
Prime Medicine Inc is a biotechnology company focused on developing a new class of genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its program, PM577 for Wilson Disease, is designed to initially correct the H1069Q mutation in the ATP7B gene and is supported by preclinical data showing targeted correction and restoration of copper homeostasis in animal models. In addition, PM647 is being developed for alpha-1 antitrypsin deficiency, or AATD, another liver targeted disease with substantial unmet need.
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