Prime MedicinePRME +8.45%25 3-Year ROIIC % is -89.07 as of Dec. 2025. GuruFocus rates PRME with a GF Score™ of 25/100. The stock has 5 warning signs investors should review. Among 1,324 Biotechnology companies, Prime Medicine ranks worse than 71.53% on this metric.
3-Year Return on Invested Incremental Capital (3-Year ROIIC %) measures the change in earnings as a percentage of change in investment over 3-year.
Prime Medicine's 3-Year ROIIC % for the quarter that ended in Dec. 2025 was -89.07%. High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
The industry rank for Prime Medicine's 3-Year ROIIC % or its related term are showing as below:
PRME's 3-Year ROIIC % is ranked worse than 71.53% of 1324
companies
in the Biotechnology industry
Industry Median: -4.63
vs PRME: -89.07
Prime Medicine (NAS:PRME) 3-Year ROIIC % Explanation
Return on Incremental Invested Capital (ROIIC) is an extension of Return on Investment Capital (ROIC). ROIC % tells investors how efficiently that profitability is earned per dollar of company capital. ROIIC narrows the focus even further and shows how profitable each additional unit of capital investment could be. ROIIC % is a more powerful metric than ROIC because it measures how much money the company can generate going forward on future capital investments.
High ROIIC is generally an indication that your business is capital efficient or has a higher operating leverage.
Be Aware
It's important to keep in mind that when tracking ROIIC, the metric is better suited to forecasting the trend of future returns rather than measuring current return on investment.
Prime Medicine 3-Year ROIIC % Related Terms
Prime Medicine 3-Year ROIIC % Historical Data
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The historical data trend for Prime Medicine's 3-Year ROIIC % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PRME vs EIKN, CRMD, STTK: 3-Year ROIIC % Comparison
For the Biotechnology subindustry, Prime Medicine's 3-Year ROIIC %, along with its competitors' market caps and 3-Year ROIIC % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Prime Medicine 3-Year ROIIC % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Prime Medicine's 3-Year ROIIC % distribution charts can be found below:
* The bar in red indicates where Prime Medicine's 3-Year ROIIC % falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
** Annual data of NOPAT and Invested Capital was used to calculate 3-Year ROIIC %.
*** Please be aware that the ROIIC (Return on Invested Capital) calculations are based on company-level data using the primary share class. The calculated data provided is for demonstration purposes and may slightly differ from the results displayed in the title due to potential variations caused by currency exchange rate differences throughout the year.
Prime Medicine (PRME) has a 3-Year ROIIC % of -89.07 as of Dec. 2025. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Prime Medicine and its competitors. According to the industry distribution chart, Prime Medicine ranks #947 out of 1324 companies in the Biotechnology industry, placing it in the top 71.5%.
Is Prime Medicine's 3-Year ROIIC % too high?
Prime Medicine's current 3-Year ROIIC % is -89.07. Based on the distribution chart, Prime Medicine ranks #947 out of 1324 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Prime Medicine has a GF Score™ of 25/100, reflecting its overall financial health beyond just this single metric.
How does Prime Medicine's 3-Year ROIIC % compare to EIKN and CRMD?
According to the Biotechnology industry distribution chart, Prime Medicine ranks #947 out of 1324 companies for 3-Year ROIIC %. This places Prime Medicine in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year ROIIC % for a Biotechnology company?
A good 3-Year ROIIC % depends on the Biotechnology industry context. However, 3-Year ROIIC % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year ROIIC % mean?
A high 3-Year ROIIC % can signal that a stock is expensive relative to its fundamentals. 3-Year ROIIC % measures the change in earnings as a percentage of change in investment over 3-year. View historical data on Prime Medicine and its competitors. Prime Medicine's current 3-Year ROIIC % is -89.07. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prime Medicine stock overvalued right now?
Prime Medicine (PRME) has a current 3-Year ROIIC % of -89.07. The current 3-Year ROIIC % is -89.07. Prime Medicine's overall GF Score™ is 25/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year ROIIC % calculated?
3-Year ROIIC % is calculated from a company's financial statements. For Prime Medicine (PRME), the current 3-Year ROIIC % is -89.07 as of Dec. 2025. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Prime Medicine Inc is a biotechnology company focused on developing a new class of genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its program, PM577 for Wilson Disease, is designed to initially correct the H1069Q mutation in the ATP7B gene and is supported by preclinical data showing targeted correction and restoration of copper homeostasis in animal models. In addition, PM647 is being developed for alpha-1 antitrypsin deficiency, or AATD, another liver targeted disease with substantial unmet need.
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