Richard Sloan from the University of Michigan was first to document what is referred to as the "accrual anomaly". His 1996 paper found that shares of companies with small or negative accruals vastly outperform (+10%) those of companies with large ones.
Prime Medicine's Sloan Ratio for the quarter that ended in Mar. 2026 was -8.25%.
As of Mar. 2026, Prime Medicine has a Sloan Ratio of -8.25%, indicating the company is in the safe zone and there is no funny business with accruals.
Prime Medicine (NAS:PRME) Sloan Ratio % Explanation
A former University of Michigan researcher, Richard Sloan's 1996 paper found that shares of companies with small or negative accruals vastly outperform (+10%) those of companies with large ones. In fact, for the 40-year period between 1962 and 2001, buying the lowest accrual companies and shorting the highest accrual companies resulted in an average annual compounded return of 18%, more than double the S&P 500's 7.4% annual return over the same period.
If the Sloan Ratio is between -10% and 10%, the company is in the safe zone and there is no funny business with accruals.
If the Sloan Ratio is less than between -25% and -10% on the negative side, and between 10% and 25% on the positive side, this is a warning stage of accrual build up.
If the Sloan Ratio is less than -25% or greater than 25%, and this ratio is consistent over several quarters or even years, be careful. Earnings are highly likely to be made up of accruals.
As of Mar. 2026, Prime Medicine has a Sloan Ratio of -8.25%, indicating the company is in the safe zone and there is no funny business with accruals.
Prime Medicine Sloan Ratio % Related Terms
Prime Medicine Sloan Ratio % Historical Data
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The historical data trend for Prime Medicine's Sloan Ratio % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
PRME vs EIKN, CRMD, STTK: Sloan Ratio % Comparison
For the Biotechnology subindustry, Prime Medicine's Sloan Ratio %, along with its competitors' market caps and Sloan Ratio % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Prime Medicine Sloan Ratio % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Prime Medicine's Sloan Ratio % distribution charts can be found below:
* The bar in red indicates where Prime Medicine's Sloan Ratio % falls into.
Earnings contain a lot of non cash earnings which is called accruals. The Sloan ratio is a way to identify firms with low non-cash or accrual-derived earnings relative to their cash flow.
Prime Medicine's Sloan Ratio for the fiscal year that ended in Dec. 2025 is calculated as
Prime Medicine's Net Income for the trailing twelve months (TTM) ended in Mar. 2026 was -52.591 (Jun. 2025 ) + -50.582 (Sep. 2025 ) + -46.079 (Dec. 2025 ) + -49.122 (Mar. 2026 ) = $-198.37 Mil.
Prime Medicine's Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 was -41.412 (Jun. 2025 ) + -35.039 (Sep. 2025 ) + -37.256 (Dec. 2025 ) + -42.71 (Mar. 2026 ) = $-156.42 Mil.
Prime Medicine's Cash Flow from Investing for the trailing twelve months (TTM) ended in Mar. 2026 was 2.771 (Jun. 2025 ) + -92.122 (Sep. 2025 ) + 28.33 (Dec. 2025 ) + 43.391 (Mar. 2026 ) = $-17.63 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Prime Medicine (PRME) has a Sloan Ratio % of -8.25% as of Mar. 2026. Sloan ratio measures earnings quality based on the amount of accruals. View historical data on Prime Medicine and its competitors.
Is Prime Medicine's Sloan Ratio % too high?
Prime Medicine's current Sloan Ratio % is -8.25%. Overall, Prime Medicine has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Prime Medicine's Sloan Ratio % compare to EIKN and CRMD?
Prime Medicine's Sloan Ratio % of -8.25% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Sloan Ratio % for a Biotechnology company?
A good Sloan Ratio % depends on the Biotechnology industry context. However, Sloan Ratio % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Sloan Ratio % mean?
A high Sloan Ratio % can signal that a stock is expensive relative to its fundamentals. Sloan ratio measures earnings quality based on the amount of accruals. View historical data on Prime Medicine and its competitors. Prime Medicine's current Sloan Ratio % is -8.25%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Prime Medicine stock overvalued right now?
Prime Medicine (PRME) has a current Sloan Ratio % of -8.25%. The current Sloan Ratio % is -8.25%. Prime Medicine's overall GF Score™ is 26/100 with 5 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Sloan Ratio % calculated?
Sloan Ratio % is calculated from a company's financial statements. For Prime Medicine (PRME), the current Sloan Ratio % is -8.25% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Prime Medicine Inc is a biotechnology company focused on developing a new class of genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its program, PM577 for Wilson Disease, is designed to initially correct the H1069Q mutation in the ATP7B gene and is supported by preclinical data showing targeted correction and restoration of copper homeostasis in animal models. In addition, PM647 is being developed for alpha-1 antitrypsin deficiency, or AATD, another liver targeted disease with substantial unmet need.
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