SYRE (Spyre Therapeutics) Cash Flow from Operations: $-208.94 Mil (TTM As of Jun. 2026)

Spyre Therapeutics  (NAS:SYRE) Cash Flow from Operations Explanation

For companies reported in indirect method, cash flow from operations contains six items:

1. Net Income From Continuing Operations:
Net Income From Continuing Operations indicates the net income that a firm brings in from ongoing business activities. These activities are expected to continue into the next reporting period. It excludes extraordinary items, income from the cumulative effects of accounting changes, non-recurring items, income from tax loss carry forward, and preferred dividends.

Spyre Therapeutics's net income from continuing operations for the three months ended in Jun. 2026 was $-36.20 Mil.

2. Depreciation, Depletion and Amortization:
Depreciation is a present expense that accounts for the past cost of an asset that is now providing benefits.
Depletion and amortization are synonyms for depreciation.
Generally:
The term depreciation is used when discussing man made tangible assets
The term depletion is used when discussing natural tangible assets
The term amortization is used when discussing intangible assets

Spyre Therapeutics's depreciation, depletion and amortization for the three months ended in Jun. 2026 was $0.00 Mil.

3. Change In Working Capital:
Working Capital is a measure of a company's short term liquidity or its ability to cover short term liabilities. It is defined as the difference between a company's current assets and current liabilities. Changes in Working Capital is reported in the cash flow statement since it is one of the major ways in which net income can differ from operating cash flow.

Spyre Therapeutics's change in working capital for the three months ended in Jun. 2026 was $-9.01 Mil. It means Spyre Therapeutics's working capital declined by $9.01 Mil from Mar. 2026 to Jun. 2026 .

4. Deferred Tax:
It is the cash flow generated from deferred tax.

Spyre Therapeutics's cash flow from deferred tax for the three months ended in Jun. 2026 was $0.00 Mil.

5. Cash from Discontinued Operating Activities:
Net cash from all of the entity's discontinued operating activities.

Spyre Therapeutics's cash from discontinued operating Activities for the three months ended in Jun. 2026 was $0.00 Mil.

6. Asset Impairment Charge:
It is the charge against earnings resulting from the aggregate write down of all assets from their carrying value to their fair value.

Spyre Therapeutics's asset impairment charge for the three months ended in Jun. 2026 was $0.00 Mil.

7. Stock Based Compensation:
It is a way corporations use stock options to reward employees. It provides executives and employees the opportunity to share in the growth of the company and, if structured properly, can align their interests with the interests of the company's shareholders and investors, without burning the company's cash on hand.

Spyre Therapeutics's stock based compensation for the three months ended in Jun. 2026 was $13.51 Mil.

8. Cash Flow from Others:
These are cash differences caused by the change of inventory, accounts payable, accounts receivable etc. For instance, if a company pays its suppliers slower, its cash position will build up faster. If a company receives payments from its customers slower, its account receivables will rise, and its cash position will grow more slowly (or even shrink).

Spyre Therapeutics's cash flow from others for the three months ended in Jun. 2026 was $-38.18 Mil.

Spyre Therapeutics Cash Flow from Operations Related Terms

The historical data trend for Spyre Therapeutics's Cash Flow from Operations can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spyre Therapeutics Cash Flow from Operations Chart

Spyre Therapeutics Annual Data
	Trend	Dec16	Dec17	Dec18	Dec19	Dec20	Dec21	Dec22	Dec23	Dec24	Dec25
Cash Flow from Operations		Get a 7-Day Free Trial					-53.72	-80.14	-99.91	-157.41	-169.25

Spyre Therapeutics Quarterly Data
	Sep21	Dec21	Mar22	Jun22	Sep22	Dec22	Mar23	Jun23	Sep23	Dec23	Mar24	Jun24	Sep24	Dec24	Mar25	Jun25	Sep25	Dec25	Mar26	Jun26
Cash Flow from Operations	Get a 7-Day Free Trial															-46.56	-37.12	-44.58	-57.37	-69.88

Spyre Therapeutics Cash Flow from Operations Calculation

Cash flow from operations refers to the cash brought in through a company's normal business operations. It is the cash flow before any investment or financing activities. It is the cash version of net income.

Spyre Therapeutics's Cash Flow from Operations for the fiscal year that ended in Dec. 2025 is calculated as:

Spyre Therapeutics's Cash Flow from Operations for the quarter that ended in Jun. 2026 is:

Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-208.94 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spyre Therapeutics Business Description